FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085644562> ?p ?o ?g. }

• W2085644562 endingPage "2217" @default.
• W2085644562 startingPage "2211" @default.
• W2085644562 abstract "Abstract Because of its ability to mimic a low energy status of the cell, the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside was proposed as an antineoplastic agent switching off major energy-consuming processes associated with the malignant phenotype (lipid production, DNA synthesis, cell proliferation, cell migration, etc.). Key to the antineoplastic action of AICA riboside is its conversion to ZMP, an AMP mimetic that at high concentrations activates the AMP-activated protein kinase (AMPK). Here, in an attempt to increase the efficacy of AICA riboside, we pretreated cancer cells with methotrexate, an antimetabolite blocking the metabolism of ZMP. Methotrexate enhanced the AICA riboside–induced accumulation of ZMP and led to a decrease in the levels of ATP, which functions as an intrasteric inhibitor of AMPK. Consequently, methotrexate markedly sensitized AMPK for activation by AICA riboside and potentiated the inhibitory effects of AICA riboside on tumor-associated processes. As cotreatment elicited antiproliferative effects already at concentrations of compounds that were only marginally effective when used alone, our findings on the cooperation between methotrexate and AICA riboside provide new opportunities both for the application of classic antimetabolic chemotherapeutics, such as methotrexate, and for the exploitation of the energy-sensing machinery as a target for cancer intervention. [Mol Cancer Ther 2006;5(9):2211–7]" @default.
• W2085644562 created "2016-06-24" @default.
• W2085644562 creator A5016435003 @default.
• W2085644562 creator A5019459881 @default.
• W2085644562 creator A5025303265 @default.
• W2085644562 creator A5026213024 @default.
• W2085644562 creator A5026838534 @default.
• W2085644562 creator A5030603760 @default.
• W2085644562 creator A5054734421 @default.
• W2085644562 creator A5061944011 @default.
• W2085644562 creator A5062031834 @default.
• W2085644562 creator A5090586027 @default.
• W2085644562 date "2006-09-01" @default.
• W2085644562 modified "2023-10-09" @default.
• W2085644562 title "Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside" @default.
• W2085644562 cites W1491882973 @default.
• W2085644562 cites W1570911552 @default.
• W2085644562 cites W1625866499 @default.
• W2085644562 cites W1663665741 @default.
• W2085644562 cites W1702423934 @default.
• W2085644562 cites W1964795260 @default.
• W2085644562 cites W1983416032 @default.
• W2085644562 cites W1990308195 @default.
• W2085644562 cites W2000566591 @default.
• W2085644562 cites W2005025180 @default.
• W2085644562 cites W2012353583 @default.
• W2085644562 cites W2027442494 @default.
• W2085644562 cites W2031376508 @default.
• W2085644562 cites W2033823674 @default.
• W2085644562 cites W2038069644 @default.
• W2085644562 cites W2046304613 @default.
• W2085644562 cites W2047861739 @default.
• W2085644562 cites W2066346666 @default.
• W2085644562 cites W2076572520 @default.
• W2085644562 cites W2077945404 @default.
• W2085644562 cites W2101351673 @default.
• W2085644562 cites W2118029488 @default.
• W2085644562 cites W2131734657 @default.
• W2085644562 cites W2149785020 @default.
• W2085644562 cites W2151510581 @default.
• W2085644562 cites W2411104574 @default.
• W2085644562 doi "https://doi.org/10.1158/1535-7163.mct-06-0001" @default.
• W2085644562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16985054" @default.
• W2085644562 hasPublicationYear "2006" @default.
• W2085644562 type Work @default.
• W2085644562 sameAs 2085644562 @default.
• W2085644562 citedByCount "52" @default.
• W2085644562 countsByYear W20856445622012 @default.
• W2085644562 countsByYear W20856445622013 @default.
• W2085644562 countsByYear W20856445622014 @default.
• W2085644562 countsByYear W20856445622015 @default.
• W2085644562 countsByYear W20856445622016 @default.
• W2085644562 countsByYear W20856445622017 @default.
• W2085644562 countsByYear W20856445622018 @default.
• W2085644562 countsByYear W20856445622019 @default.
• W2085644562 countsByYear W20856445622020 @default.
• W2085644562 countsByYear W20856445622021 @default.
• W2085644562 crossrefType "journal-article" @default.
• W2085644562 hasAuthorship W2085644562A5016435003 @default.
• W2085644562 hasAuthorship W2085644562A5019459881 @default.
• W2085644562 hasAuthorship W2085644562A5025303265 @default.
• W2085644562 hasAuthorship W2085644562A5026213024 @default.
• W2085644562 hasAuthorship W2085644562A5026838534 @default.
• W2085644562 hasAuthorship W2085644562A5030603760 @default.
• W2085644562 hasAuthorship W2085644562A5054734421 @default.
• W2085644562 hasAuthorship W2085644562A5061944011 @default.
• W2085644562 hasAuthorship W2085644562A5062031834 @default.
• W2085644562 hasAuthorship W2085644562A5090586027 @default.
• W2085644562 hasConcept C104317684 @default.
• W2085644562 hasConcept C149011108 @default.
• W2085644562 hasConcept C184235292 @default.
• W2085644562 hasConcept C185592680 @default.
• W2085644562 hasConcept C203014093 @default.
• W2085644562 hasConcept C2776328115 @default.
• W2085644562 hasConcept C2778397455 @default.
• W2085644562 hasConcept C2780124434 @default.
• W2085644562 hasConcept C2780549722 @default.
• W2085644562 hasConcept C2781059491 @default.
• W2085644562 hasConcept C2781382166 @default.
• W2085644562 hasConcept C55493867 @default.
• W2085644562 hasConcept C86803240 @default.
• W2085644562 hasConcept C97029542 @default.
• W2085644562 hasConcept C98274493 @default.
• W2085644562 hasConceptScore W2085644562C104317684 @default.
• W2085644562 hasConceptScore W2085644562C149011108 @default.
• W2085644562 hasConceptScore W2085644562C184235292 @default.
• W2085644562 hasConceptScore W2085644562C185592680 @default.
• W2085644562 hasConceptScore W2085644562C203014093 @default.
• W2085644562 hasConceptScore W2085644562C2776328115 @default.
• W2085644562 hasConceptScore W2085644562C2778397455 @default.
• W2085644562 hasConceptScore W2085644562C2780124434 @default.
• W2085644562 hasConceptScore W2085644562C2780549722 @default.
• W2085644562 hasConceptScore W2085644562C2781059491 @default.
• W2085644562 hasConceptScore W2085644562C2781382166 @default.
• W2085644562 hasConceptScore W2085644562C55493867 @default.
• W2085644562 hasConceptScore W2085644562C86803240 @default.
• W2085644562 hasConceptScore W2085644562C97029542 @default.
• W2085644562 hasConceptScore W2085644562C98274493 @default.

• next