Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085647104> ?p ?o ?g. }
- W2085647104 endingPage "1428" @default.
- W2085647104 startingPage "1422" @default.
- W2085647104 abstract "Embryonic stem cell (ESC)-derived beating cardiomyocytes may be considered as a suitable model for in vitro assessment of pharmacological and toxicological studies. In this model, laboratory animals are not required. In addition, physiological functions, such as heart beat, are assessed rather than single parameters such as cell viability. Here we report that doxorubicin (DOX) cardiotoxicity on mouse ESC-derived beating cardiomyocytes can be ameliorated by treatment with dexamethasone (DEX) when DEX is administrated only before DOX and not in combination with DOX. DEX effect appears to be mediated via glucocorticoid receptor and increases cardiomyocyte-specific gene expression. Cardiotoxicity of DOX can be augmented by calcium channel blocker, verapamil (VER) which also decreases the expression of cardiac gene markers. This model provides us with a clinical suggestion which proposes that the beneficial effect of DEX is obtained when DEX was added before DOX administration." @default.
- W2085647104 created "2016-06-24" @default.
- W2085647104 creator A5009688016 @default.
- W2085647104 creator A5019924570 @default.
- W2085647104 creator A5040975584 @default.
- W2085647104 creator A5046943747 @default.
- W2085647104 creator A5050298149 @default.
- W2085647104 creator A5051798464 @default.
- W2085647104 creator A5065815407 @default.
- W2085647104 creator A5091186278 @default.
- W2085647104 date "2009-10-01" @default.
- W2085647104 modified "2023-10-16" @default.
- W2085647104 title "Embryonic stem cell-derived cardiomyocytes as a model system to study cardioprotective effects of dexamethasone in doxorubicin cardiotoxicity" @default.
- W2085647104 cites W1760708290 @default.
- W2085647104 cites W1948938001 @default.
- W2085647104 cites W1964966322 @default.
- W2085647104 cites W1968928835 @default.
- W2085647104 cites W1972662556 @default.
- W2085647104 cites W1974992961 @default.
- W2085647104 cites W1978173381 @default.
- W2085647104 cites W1981809048 @default.
- W2085647104 cites W1986142580 @default.
- W2085647104 cites W1986477473 @default.
- W2085647104 cites W1988671949 @default.
- W2085647104 cites W1995363983 @default.
- W2085647104 cites W2002179012 @default.
- W2085647104 cites W2005061481 @default.
- W2085647104 cites W2012777643 @default.
- W2085647104 cites W2015183072 @default.
- W2085647104 cites W2036536995 @default.
- W2085647104 cites W2051395019 @default.
- W2085647104 cites W2051836246 @default.
- W2085647104 cites W2053387643 @default.
- W2085647104 cites W2056521815 @default.
- W2085647104 cites W2062640827 @default.
- W2085647104 cites W2068790526 @default.
- W2085647104 cites W2069019884 @default.
- W2085647104 cites W2073274340 @default.
- W2085647104 cites W2079870118 @default.
- W2085647104 cites W2082285218 @default.
- W2085647104 cites W2086046223 @default.
- W2085647104 cites W2089337274 @default.
- W2085647104 cites W2092837861 @default.
- W2085647104 cites W2093049418 @default.
- W2085647104 cites W2099474957 @default.
- W2085647104 cites W2103981611 @default.
- W2085647104 cites W2119288897 @default.
- W2085647104 cites W2125987139 @default.
- W2085647104 cites W2136938687 @default.
- W2085647104 cites W2138977668 @default.
- W2085647104 cites W2142046859 @default.
- W2085647104 cites W2145492799 @default.
- W2085647104 cites W2150197150 @default.
- W2085647104 cites W2155016057 @default.
- W2085647104 cites W2157645703 @default.
- W2085647104 cites W2170560537 @default.
- W2085647104 cites W2430269738 @default.
- W2085647104 cites W2472159018 @default.
- W2085647104 cites W27814405 @default.
- W2085647104 cites W306306696 @default.
- W2085647104 doi "https://doi.org/10.1016/j.tiv.2009.07.008" @default.
- W2085647104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19596060" @default.
- W2085647104 hasPublicationYear "2009" @default.
- W2085647104 type Work @default.
- W2085647104 sameAs 2085647104 @default.
- W2085647104 citedByCount "26" @default.
- W2085647104 countsByYear W20856471042012 @default.
- W2085647104 countsByYear W20856471042013 @default.
- W2085647104 countsByYear W20856471042014 @default.
- W2085647104 countsByYear W20856471042015 @default.
- W2085647104 countsByYear W20856471042018 @default.
- W2085647104 crossrefType "journal-article" @default.
- W2085647104 hasAuthorship W2085647104A5009688016 @default.
- W2085647104 hasAuthorship W2085647104A5019924570 @default.
- W2085647104 hasAuthorship W2085647104A5040975584 @default.
- W2085647104 hasAuthorship W2085647104A5046943747 @default.
- W2085647104 hasAuthorship W2085647104A5050298149 @default.
- W2085647104 hasAuthorship W2085647104A5051798464 @default.
- W2085647104 hasAuthorship W2085647104A5065815407 @default.
- W2085647104 hasAuthorship W2085647104A5091186278 @default.
- W2085647104 hasConcept C104317684 @default.
- W2085647104 hasConcept C126322002 @default.
- W2085647104 hasConcept C134018914 @default.
- W2085647104 hasConcept C145103041 @default.
- W2085647104 hasConcept C1491633281 @default.
- W2085647104 hasConcept C185592680 @default.
- W2085647104 hasConcept C2776694085 @default.
- W2085647104 hasConcept C2777022698 @default.
- W2085647104 hasConcept C2778233292 @default.
- W2085647104 hasConcept C2780401358 @default.
- W2085647104 hasConcept C2780841215 @default.
- W2085647104 hasConcept C2781303535 @default.
- W2085647104 hasConcept C29730261 @default.
- W2085647104 hasConcept C519063684 @default.
- W2085647104 hasConcept C53227056 @default.
- W2085647104 hasConcept C55493867 @default.
- W2085647104 hasConcept C59493245 @default.
- W2085647104 hasConcept C71924100 @default.