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- W2085647574 abstract "A thermodynamic evaluation of bonding in compressed tablets has been achieved providing a quantitative measure of solid paniculate interaction shown to correlate with tablet strength. The evaluation was accomplished through the design and implementation of a unique compression calorimeter capable of accurate and precise determination of the heat released during powder compaction. Concomitant measurement of the work of compaction permitted an energy balance for the tableting process such that the energy difference between powder and tablet could be accurately assessed. The experimentally determined energy differences at maximum compression force (30,000 N) for 4 pure directly compressible materials (Avicel, DiTab, Fast Flo lactose, Starch 1500) indicate that the formation of a tablet is associated with a decrease in energy of the system. This decrease in energy, termed the energy of formation, is related to the dissipation of surface energy associated with bonding. The compression of a particulate system which did not form a strong tablet presented a much smaller energy of formation at maximum compression force (10.6 J for Avicel versus 0.52 J for granular acetaminophen) and thus demonstrates the potential of the compression calorimeter as a device capable of quantitatively determining energetic differences resulting from the compaction process. The tensile strength measurements for each compressible material are also shown to correlate with the energy of formation." @default.
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- W2085647574 date "1983-12-01" @default.
- W2085647574 modified "2023-10-18" @default.
- W2085647574 title "Determination of the energy of tablet formation during compression of selected pharmaceutical powders" @default.
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- W2085647574 doi "https://doi.org/10.1016/0378-5173(83)90042-x" @default.
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