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• W2085648340 abstract "Until recently, the therapeutic effects of furocoumarins and furochromones plus UV-A light were thought to be due to their ability to form photoadducts with DNA in the cell nuclei; now it appears that membrane effector systems may be involved as targets. Here we show that in HeLa cells khellin at 1 and 5 μM final concentration, in combination with UV-A light, inhibits NaF-stimulated adenylyl cyclase activity and Pertussis Toxin (PT)-catalyzed ADP-ribosylation of α-subunits of inhibitory guanine nucleotide regulatory proteins (Gi) and increases GTPase activity. In the same experimental conditions, 8-methoxypsoralen (8-MOP), either alone or plus UV-A, does not affect adenylyl cyclase and GTPase activities. Our results suggest that in HeLa cells, through an interaction with a receptor and the mediation of Gi proteins, the adenylyl cyclase system is a target for khellin but not for 8-MOP." @default.
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• W2085648340 date "1995-11-01" @default.
• W2085648340 modified "2023-09-27" @default.
• W2085648340 title "Khellin, but not 8-methoxypsoralen, inhibits adenylyl cyclase system in HeLa cells" @default.
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• W2085648340 doi "https://doi.org/10.1016/0167-4889(95)00115-9" @default.
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