FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085651819> ?p ?o ?g. }

• W2085651819 endingPage "e0118605" @default.
• W2085651819 startingPage "e0118605" @default.
• W2085651819 abstract "Background Pyrus pashia Buch.-Ham. ex D. Don. has been used conventionally by many communities in the Himalayan region for the management of gastrointestinal, respiratory, and vascular complications. Set against this background, this study was carried out to justify the scientific basis to validate folkloric uses of fruits of Pyrus pashia Buch.-Ham. ex D. Don. (Pp.Cr) in traditional systems of medicine. Methods The crude ethanol extract of fruits of Pyrus pashia Buch.-Ham. ex D. Don. (Pp.Cr) was tested in vitro on isolated rabbit jejunum, tracheal, and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with a PowerLab data acquisition system. Results The Pp.Cr on application (0.01–5.0 mg/ml) to isolated rabbit jejunum preparation exhibited relaxation through decrease in magnitude and frequency of spontaneous contractions. The Pp.Cr also exerted a relaxant (0.01–5.0 mg/ml) effect on K+(80 mM) induced contractions in isolated rabbit jejunum preparations and caused shifting of the Ca2+ curves (1.0–3.0 mg/ml) toward right in a manner similar to that of verapamil (3μM), possibly suggesting presence of Ca2+ channel blocking activity. Subsequently, Pp.Cr in a concentration-dependent fashion (0.01–10.0 mg/ml) caused relaxation of CCh (1μM) and K+ (80 mM) induced contractions in isolated rabbit tracheal preparations in a manner comparable to that of dicyclomine, suggesting that the observed relaxant effect is likely to be mediated through antimuscarinic and/or Ca2+ channel blocking activities. Moreover, when evaluated against isolated rabbit aortic preparations, the Pp.Cr in concentrations up to 10 mg/ml exhibited a contractile response that was found to be abolished subsequent to pretreatment of isolated tissue preparation with cyproheptadine (1μM), phentolamine (1μM), and losartan (1μM), suggesting that Pp.Cr may have some α-adrenergic, muscarinic, serotonergic, and angiotensin II activities. Conclusions The aqueous ethanolic extract of Pyrus pashia (Pp.Cr) exhibited spasmolytic, bronchodilator, and vaso-constrictive activities possibly through different mechanisms. The spasmolytic and bronchodilator activities are likely to be mediated through blockade of Ca2+ channels, while vasoconstrictive activity may be due to presence of a α-adrenergic, muscarinic, serotonergic, and angiotensin II agonistic component." @default.
• W2085651819 created "2016-06-24" @default.
• W2085651819 creator A5010899653 @default.
• W2085651819 creator A5011230028 @default.
• W2085651819 creator A5016710130 @default.
• W2085651819 creator A5036224961 @default.
• W2085651819 creator A5054386137 @default.
• W2085651819 creator A5058569326 @default.
• W2085651819 creator A5064692439 @default.
• W2085651819 creator A5076042675 @default.
• W2085651819 date "2015-03-18" @default.
• W2085651819 modified "2023-09-24" @default.
• W2085651819 title "Scientific Basis for Use of Pyrus pashia Buch.-Ham. ex D. Don. Fruit in Gastrointestinal, Respiratory and Cardiovascular Ailments" @default.
• W2085651819 cites W1485604630 @default.
• W2085651819 cites W1570919956 @default.
• W2085651819 cites W1844605916 @default.
• W2085651819 cites W1875475552 @default.
• W2085651819 cites W1972692426 @default.
• W2085651819 cites W1976289607 @default.
• W2085651819 cites W1982739659 @default.
• W2085651819 cites W1984943870 @default.
• W2085651819 cites W2001583718 @default.
• W2085651819 cites W2018913233 @default.
• W2085651819 cites W2023381687 @default.
• W2085651819 cites W2030070360 @default.
• W2085651819 cites W2033725326 @default.
• W2085651819 cites W2034988617 @default.
• W2085651819 cites W2061500670 @default.
• W2085651819 cites W2061567002 @default.
• W2085651819 cites W2073562644 @default.
• W2085651819 cites W2076862255 @default.
• W2085651819 cites W2078636462 @default.
• W2085651819 cites W2084388654 @default.
• W2085651819 cites W2090134883 @default.
• W2085651819 cites W2094441518 @default.
• W2085651819 cites W2120240877 @default.
• W2085651819 cites W2146173177 @default.
• W2085651819 cites W2149418938 @default.
• W2085651819 cites W2164492968 @default.
• W2085651819 cites W2167937003 @default.
• W2085651819 cites W2172081674 @default.
• W2085651819 cites W2173520866 @default.
• W2085651819 cites W2185541963 @default.
• W2085651819 cites W2187854995 @default.
• W2085651819 cites W2384697622 @default.
• W2085651819 cites W4248754074 @default.
• W2085651819 cites W44420309 @default.
• W2085651819 doi "https://doi.org/10.1371/journal.pone.0118605" @default.
• W2085651819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4364991" @default.
• W2085651819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25786248" @default.
• W2085651819 hasPublicationYear "2015" @default.
• W2085651819 type Work @default.
• W2085651819 sameAs 2085651819 @default.
• W2085651819 citedByCount "31" @default.
• W2085651819 countsByYear W20856518192015 @default.
• W2085651819 countsByYear W20856518192016 @default.
• W2085651819 countsByYear W20856518192017 @default.
• W2085651819 countsByYear W20856518192018 @default.
• W2085651819 countsByYear W20856518192019 @default.
• W2085651819 countsByYear W20856518192020 @default.
• W2085651819 countsByYear W20856518192021 @default.
• W2085651819 countsByYear W20856518192022 @default.
• W2085651819 countsByYear W20856518192023 @default.
• W2085651819 crossrefType "journal-article" @default.
• W2085651819 hasAuthorship W2085651819A5010899653 @default.
• W2085651819 hasAuthorship W2085651819A5011230028 @default.
• W2085651819 hasAuthorship W2085651819A5016710130 @default.
• W2085651819 hasAuthorship W2085651819A5036224961 @default.
• W2085651819 hasAuthorship W2085651819A5054386137 @default.
• W2085651819 hasAuthorship W2085651819A5058569326 @default.
• W2085651819 hasAuthorship W2085651819A5064692439 @default.
• W2085651819 hasAuthorship W2085651819A5076042675 @default.
• W2085651819 hasBestOaLocation W20856518191 @default.
• W2085651819 hasConcept C126322002 @default.
• W2085651819 hasConcept C185592680 @default.
• W2085651819 hasConcept C202751555 @default.
• W2085651819 hasConcept C26291073 @default.
• W2085651819 hasConcept C2776366702 @default.
• W2085651819 hasConcept C2777022698 @default.
• W2085651819 hasConcept C42219234 @default.
• W2085651819 hasConcept C519063684 @default.
• W2085651819 hasConcept C534529494 @default.
• W2085651819 hasConcept C55493867 @default.
• W2085651819 hasConcept C71924100 @default.
• W2085651819 hasConcept C98274493 @default.
• W2085651819 hasConceptScore W2085651819C126322002 @default.
• W2085651819 hasConceptScore W2085651819C185592680 @default.
• W2085651819 hasConceptScore W2085651819C202751555 @default.
• W2085651819 hasConceptScore W2085651819C26291073 @default.
• W2085651819 hasConceptScore W2085651819C2776366702 @default.
• W2085651819 hasConceptScore W2085651819C2777022698 @default.
• W2085651819 hasConceptScore W2085651819C42219234 @default.
• W2085651819 hasConceptScore W2085651819C519063684 @default.
• W2085651819 hasConceptScore W2085651819C534529494 @default.
• W2085651819 hasConceptScore W2085651819C55493867 @default.
• W2085651819 hasConceptScore W2085651819C71924100 @default.
• W2085651819 hasConceptScore W2085651819C98274493 @default.
• W2085651819 hasIssue "3" @default.

• next