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- W2085652917 abstract "Ticlopidine and clopidogrel are two thienopyridines with potent and apparently irreversible platelet inhibitory properties. The antiplatelet effects are mainly directed against ADP-induced stimulation of platelet function, in particular ADP-induced inhibition of adenylyl cyclase stimulation. There is evidence for additional effects, including inhibition of agonist-induced intracellular Ca++ mobilization, interference with GpIIb/IIIa receptor/agonist interaction and inhibition of α-granule secretion. However, these actions are probably secondary to the ADP-antagonistic action.Thienopyridines do not directly interfere with arachidonic acid metabolism. The substances are inactive in vitro and have to undergo some form of bioactivation in vivo which requires 3 to 5 days of treatment for a maximum effect. The nature of the postulated active metabolite(s) is still unknown. From a pharmacological point of view, thienopyridines may be considered interesting alternatives to acetylsalicylic acid with particular value in shear-stress-mediated platelet activation, for example in prevention of acute thrombembolic risk in injury-related vessel stenosis." @default.
- W2085652917 created "2016-06-24" @default.
- W2085652917 creator A5056255955 @default.
- W2085652917 date "1993-01-01" @default.
- W2085652917 modified "2023-09-27" @default.
- W2085652917 title "The Basic Pharmacology of Ticlopidine and Clopidogrel" @default.
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- W2085652917 doi "https://doi.org/10.3109/09537109309013225" @default.
- W2085652917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21043748" @default.
- W2085652917 hasPublicationYear "1993" @default.
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