Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085653933> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2085653933 endingPage "579" @default.
- W2085653933 startingPage "570" @default.
- W2085653933 abstract "In an attempt to understand the evolutionary history of the major histocompatibility complex, we have characterized crossreactive molecules from nonmammalian vertebrates using rabbit antisera and monoclonal antibodies to mammalian and chicken MHC molecules. By this analysis, some chains of these heterodimers evolve more slowly than others, and interdomain contact sites evolve more slowly than surface residues. The antibodies to human MHC molecules crossreacted with amphibians much better than reptiles, the reverse was true for the antibodies to chicken MHC molecules, while neither crossreacted with recognizable molecules in fish. We then analyzed a chicken class I heterodimer in detail, and found that homologous domains have different rates of evolution, that most (but not all) interdomain and intradomain contacts are conserved or invariant, that the surface residues are quite diverged, but that patches of invariant residues occur in areas thought to interact with other molecules. Some of the domains are encoded by exons very rich in guanine and cytosine, to the point of affecting the amino acid composition relative to mammals. We present a very speculative model, in which the antigenic similarities of reptile and bird MHC molecules compared to mammals and amphibians are due to this high content of guanine and cytosine, and this in turn is due to the presence of these genes on microchromosomes. Finally, we try to explain the compressed nature of chicken immunoglobulin loci as another consequence of location on microchromosomes" @default.
- W2085653933 created "2016-06-24" @default.
- W2085653933 creator A5004814650 @default.
- W2085653933 creator A5047215816 @default.
- W2085653933 creator A5080585460 @default.
- W2085653933 creator A5087875042 @default.
- W2085653933 date "1991-06-01" @default.
- W2085653933 modified "2023-10-04" @default.
- W2085653933 title "Using Chicken Class I Sequences to Understand How Xenoantibodies Crossreact with MHC-like Molecules in Nonmammalian Vertebrates" @default.
- W2085653933 doi "https://doi.org/10.1093/icb/31.3.570" @default.
- W2085653933 hasPublicationYear "1991" @default.
- W2085653933 type Work @default.
- W2085653933 sameAs 2085653933 @default.
- W2085653933 citedByCount "5" @default.
- W2085653933 crossrefType "journal-article" @default.
- W2085653933 hasAuthorship W2085653933A5004814650 @default.
- W2085653933 hasAuthorship W2085653933A5047215816 @default.
- W2085653933 hasAuthorship W2085653933A5080585460 @default.
- W2085653933 hasAuthorship W2085653933A5087875042 @default.
- W2085653933 hasBestOaLocation W20856539331 @default.
- W2085653933 hasConcept C104317684 @default.
- W2085653933 hasConcept C159654299 @default.
- W2085653933 hasConcept C170627219 @default.
- W2085653933 hasConcept C207936829 @default.
- W2085653933 hasConcept C2776023528 @default.
- W2085653933 hasConcept C2778961482 @default.
- W2085653933 hasConcept C54355233 @default.
- W2085653933 hasConcept C78458016 @default.
- W2085653933 hasConcept C86803240 @default.
- W2085653933 hasConceptScore W2085653933C104317684 @default.
- W2085653933 hasConceptScore W2085653933C159654299 @default.
- W2085653933 hasConceptScore W2085653933C170627219 @default.
- W2085653933 hasConceptScore W2085653933C207936829 @default.
- W2085653933 hasConceptScore W2085653933C2776023528 @default.
- W2085653933 hasConceptScore W2085653933C2778961482 @default.
- W2085653933 hasConceptScore W2085653933C54355233 @default.
- W2085653933 hasConceptScore W2085653933C78458016 @default.
- W2085653933 hasConceptScore W2085653933C86803240 @default.
- W2085653933 hasIssue "3" @default.
- W2085653933 hasLocation W20856539331 @default.
- W2085653933 hasOpenAccess W2085653933 @default.
- W2085653933 hasPrimaryLocation W20856539331 @default.
- W2085653933 hasRelatedWork W1485946719 @default.
- W2085653933 hasRelatedWork W1858230739 @default.
- W2085653933 hasRelatedWork W1899217451 @default.
- W2085653933 hasRelatedWork W1969089800 @default.
- W2085653933 hasRelatedWork W2009104988 @default.
- W2085653933 hasRelatedWork W2040169722 @default.
- W2085653933 hasRelatedWork W2052968225 @default.
- W2085653933 hasRelatedWork W2095550728 @default.
- W2085653933 hasRelatedWork W2099893709 @default.
- W2085653933 hasRelatedWork W2133029485 @default.
- W2085653933 hasRelatedWork W2170884537 @default.
- W2085653933 hasRelatedWork W2345040521 @default.
- W2085653933 hasRelatedWork W2411591729 @default.
- W2085653933 hasRelatedWork W2462789975 @default.
- W2085653933 hasRelatedWork W2764627887 @default.
- W2085653933 hasRelatedWork W2981732342 @default.
- W2085653933 hasRelatedWork W3005060794 @default.
- W2085653933 hasRelatedWork W3127980420 @default.
- W2085653933 hasRelatedWork W3158205715 @default.
- W2085653933 hasRelatedWork W85668850 @default.
- W2085653933 hasVolume "31" @default.
- W2085653933 isParatext "false" @default.
- W2085653933 isRetracted "false" @default.
- W2085653933 magId "2085653933" @default.
- W2085653933 workType "article" @default.