FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085654814> ?p ?o ?g. }

• W2085654814 endingPage "e89417" @default.
• W2085654814 startingPage "e89417" @default.
• W2085654814 abstract "Clostridium difficile infections are an emerging health problem in the modern hospital environment. Severe alterations of the gut microbiome with loss of resistance to colonization against C. difficile are thought to be the major trigger, but there is no clear concept of how C. difficile infection evolves and which microbiological factors are involved. We sequenced 16S rRNA amplicons generated from DNA and RNA/cDNA of fecal samples from three groups of individuals by FLX technology: (i) healthy controls (no antibiotic therapy); (ii) individuals receiving antibiotic therapy (Ampicillin/Sulbactam, cephalosporins, and fluoroquinolones with subsequent development of C. difficile infection or (iii) individuals receiving antibiotic therapy without C. difficile infection. We compared the effects of the three different antibiotic classes on the intestinal microbiome and the effects of alterations of the gut microbiome on C. difficile infection at the DNA (total microbiota) and rRNA (potentially active) levels. A comparison of antibiotic classes showed significant differences at DNA level, but not at RNA level. Among individuals that developed or did not develop a C. difficile infection under antibiotics we found no significant differences. We identified single species that were up- or down regulated in individuals receiving antibiotics who developed the infection compared to non-infected individuals. We found no significant differences in the global composition of the transcriptionally active gut microbiome associated with C. difficile infections. We suggest that up- and down regulation of specific bacterial species may be involved in colonization resistance against C. difficile providing a potential therapeutic approach through specific manipulation of the intestinal microbiome." @default.
• W2085654814 created "2016-06-24" @default.
• W2085654814 creator A5015805053 @default.
• W2085654814 creator A5024467057 @default.
• W2085654814 creator A5033241728 @default.
• W2085654814 creator A5039080047 @default.
• W2085654814 creator A5049767327 @default.
• W2085654814 creator A5054564152 @default.
• W2085654814 creator A5058858179 @default.
• W2085654814 creator A5059189176 @default.
• W2085654814 creator A5059435501 @default.
• W2085654814 creator A5063428697 @default.
• W2085654814 creator A5079510935 @default.
• W2085654814 creator A5082735172 @default.
• W2085654814 creator A5086005113 @default.
• W2085654814 date "2014-02-28" @default.
• W2085654814 modified "2023-10-10" @default.
• W2085654814 title "Effects of β-Lactam Antibiotics and Fluoroquinolones on Human Gut Microbiota in Relation to Clostridium difficile Associated Diarrhea" @default.
• W2085654814 cites W1482883615 @default.
• W2085654814 cites W1492535541 @default.
• W2085654814 cites W1569647046 @default.
• W2085654814 cites W160827260 @default.
• W2085654814 cites W1963849807 @default.
• W2085654814 cites W1967821667 @default.
• W2085654814 cites W1970936978 @default.
• W2085654814 cites W1978468198 @default.
• W2085654814 cites W1984844099 @default.
• W2085654814 cites W1992815945 @default.
• W2085654814 cites W2005429741 @default.
• W2085654814 cites W2010855497 @default.
• W2085654814 cites W2012151682 @default.
• W2085654814 cites W2024601462 @default.
• W2085654814 cites W2025802417 @default.
• W2085654814 cites W2028596084 @default.
• W2085654814 cites W2032605132 @default.
• W2085654814 cites W2069894149 @default.
• W2085654814 cites W2079254902 @default.
• W2085654814 cites W2089246633 @default.
• W2085654814 cites W2099119185 @default.
• W2085654814 cites W2102746137 @default.
• W2085654814 cites W2103808218 @default.
• W2085654814 cites W2104518766 @default.
• W2085654814 cites W2104905032 @default.
• W2085654814 cites W2108718991 @default.
• W2085654814 cites W2115980431 @default.
• W2085654814 cites W2120474334 @default.
• W2085654814 cites W2127634163 @default.
• W2085654814 cites W2129994723 @default.
• W2085654814 cites W2139607253 @default.
• W2085654814 cites W2139693412 @default.
• W2085654814 cites W2146624345 @default.
• W2085654814 cites W2147768095 @default.
• W2085654814 cites W2149684740 @default.
• W2085654814 cites W2152530574 @default.
• W2085654814 cites W2152589784 @default.
• W2085654814 cites W2163918813 @default.
• W2085654814 cites W2164640614 @default.
• W2085654814 cites W2167717276 @default.
• W2085654814 cites W2168247834 @default.
• W2085654814 cites W2169104975 @default.
• W2085654814 cites W2333294244 @default.
• W2085654814 cites W4239625169 @default.
• W2085654814 doi "https://doi.org/10.1371/journal.pone.0089417" @default.
• W2085654814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3938479" @default.
• W2085654814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24586762" @default.
• W2085654814 hasPublicationYear "2014" @default.
• W2085654814 type Work @default.
• W2085654814 sameAs 2085654814 @default.
• W2085654814 citedByCount "63" @default.
• W2085654814 countsByYear W20856548142014 @default.
• W2085654814 countsByYear W20856548142015 @default.
• W2085654814 countsByYear W20856548142016 @default.
• W2085654814 countsByYear W20856548142017 @default.
• W2085654814 countsByYear W20856548142018 @default.
• W2085654814 countsByYear W20856548142019 @default.
• W2085654814 countsByYear W20856548142020 @default.
• W2085654814 countsByYear W20856548142021 @default.
• W2085654814 countsByYear W20856548142022 @default.
• W2085654814 countsByYear W20856548142023 @default.
• W2085654814 crossrefType "journal-article" @default.
• W2085654814 hasAuthorship W2085654814A5015805053 @default.
• W2085654814 hasAuthorship W2085654814A5024467057 @default.
• W2085654814 hasAuthorship W2085654814A5033241728 @default.
• W2085654814 hasAuthorship W2085654814A5039080047 @default.
• W2085654814 hasAuthorship W2085654814A5049767327 @default.
• W2085654814 hasAuthorship W2085654814A5054564152 @default.
• W2085654814 hasAuthorship W2085654814A5058858179 @default.
• W2085654814 hasAuthorship W2085654814A5059189176 @default.
• W2085654814 hasAuthorship W2085654814A5059435501 @default.
• W2085654814 hasAuthorship W2085654814A5063428697 @default.
• W2085654814 hasAuthorship W2085654814A5079510935 @default.
• W2085654814 hasAuthorship W2085654814A5082735172 @default.
• W2085654814 hasAuthorship W2085654814A5086005113 @default.
• W2085654814 hasBestOaLocation W20856548141 @default.
• W2085654814 hasConcept C126322002 @default.
• W2085654814 hasConcept C143121216 @default.
• W2085654814 hasConcept C189506811 @default.
• W2085654814 hasConcept C203014093 @default.

• next