Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085655123> ?p ?o ?g. }
- W2085655123 endingPage "675" @default.
- W2085655123 startingPage "665" @default.
- W2085655123 abstract "Abstract Hydroxysteroid (17-β) dehydrogenase 2 (HSD17B2) is a member of aldo-keto reductase superfamily, known to catalyze the inactivation of 17β-hydroxysteroids to less active 17-keto forms and catalyze the conversion of 20α-hydroxyprogesterone to progesterone in vitro. To examine the role of HSD17B2 in vivo, we generated mice deficient in Hsd17b2 [HSD17B2 knockout (KO)] by a targeted gene disruption in embryonic stem cells. From the homozygous mice carrying the disrupted Hsd17b2, 70% showed embryonic lethality appearing at the age of embryonic d 11.5 onward. The embryonic lethality was associated with reduced placental size measured at embryonic d 17.5. The HSD17B2KO mice placentas presented with structural abnormalities in all three major layers: the decidua, spongiotrophoblast, and labyrinth. Most notable was the disruption of the spongiotrophoblast and labyrinthine layers, together with liquid-filled cysts in the junctional region and the basal layer. Treatments with an antiestrogen or progesterone did not rescue the embryonic lethality or the placenta defect in the homozygous mice. In hybrid background used, 24% of HSD17B2KO mice survived through the fetal period but were born growth retarded and displayed a phenotype in the brain with enlargement of ventricles, abnormal laminar organization, and increased cellular density in the cortex. Furthermore, the HSD17B2KO mice had unilateral renal degeneration, the affected kidney frequently appearing as a fluid-filled sac. Our results provide evidence for a role for HSD17B2 enzyme in the cellular organization of the mouse placenta." @default.
- W2085655123 created "2016-06-24" @default.
- W2085655123 creator A5015229978 @default.
- W2085655123 creator A5019320217 @default.
- W2085655123 creator A5024403470 @default.
- W2085655123 creator A5044475923 @default.
- W2085655123 creator A5044882291 @default.
- W2085655123 creator A5049894537 @default.
- W2085655123 creator A5064220321 @default.
- W2085655123 creator A5083633703 @default.
- W2085655123 creator A5091230903 @default.
- W2085655123 date "2008-03-01" @default.
- W2085655123 modified "2023-09-27" @default.
- W2085655123 title "Placenta Defects and Embryonic Lethality Resulting from Disruption of Mouse Hydroxysteroid (17-β) Dehydrogenase 2 Gene" @default.
- W2085655123 cites W1525342509 @default.
- W2085655123 cites W1527331090 @default.
- W2085655123 cites W1555471169 @default.
- W2085655123 cites W1561772754 @default.
- W2085655123 cites W1580639168 @default.
- W2085655123 cites W1603541383 @default.
- W2085655123 cites W1958591902 @default.
- W2085655123 cites W1978649931 @default.
- W2085655123 cites W1979328693 @default.
- W2085655123 cites W1979543372 @default.
- W2085655123 cites W1982926605 @default.
- W2085655123 cites W1988284423 @default.
- W2085655123 cites W1993330603 @default.
- W2085655123 cites W1994324783 @default.
- W2085655123 cites W1995895579 @default.
- W2085655123 cites W1999504845 @default.
- W2085655123 cites W2007917116 @default.
- W2085655123 cites W2010470589 @default.
- W2085655123 cites W2014879410 @default.
- W2085655123 cites W2029926102 @default.
- W2085655123 cites W2034440515 @default.
- W2085655123 cites W2041146811 @default.
- W2085655123 cites W2045556698 @default.
- W2085655123 cites W2049232448 @default.
- W2085655123 cites W2052532546 @default.
- W2085655123 cites W2053311013 @default.
- W2085655123 cites W2062204672 @default.
- W2085655123 cites W2075168643 @default.
- W2085655123 cites W2077840513 @default.
- W2085655123 cites W2079743814 @default.
- W2085655123 cites W2079944193 @default.
- W2085655123 cites W2081922333 @default.
- W2085655123 cites W2082559087 @default.
- W2085655123 cites W2083523447 @default.
- W2085655123 cites W2087436722 @default.
- W2085655123 cites W2088239341 @default.
- W2085655123 cites W2091579589 @default.
- W2085655123 cites W2099149147 @default.
- W2085655123 cites W2111482994 @default.
- W2085655123 cites W2115950347 @default.
- W2085655123 cites W2116838171 @default.
- W2085655123 cites W2127529986 @default.
- W2085655123 cites W2134994965 @default.
- W2085655123 cites W2136327530 @default.
- W2085655123 cites W2140475850 @default.
- W2085655123 cites W2141568746 @default.
- W2085655123 cites W2145896384 @default.
- W2085655123 cites W2164935520 @default.
- W2085655123 cites W4238598808 @default.
- W2085655123 doi "https://doi.org/10.1210/me.2007-0257" @default.
- W2085655123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5419621" @default.
- W2085655123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18048640" @default.
- W2085655123 hasPublicationYear "2008" @default.
- W2085655123 type Work @default.
- W2085655123 sameAs 2085655123 @default.
- W2085655123 citedByCount "28" @default.
- W2085655123 countsByYear W20856551232012 @default.
- W2085655123 countsByYear W20856551232013 @default.
- W2085655123 countsByYear W20856551232014 @default.
- W2085655123 countsByYear W20856551232015 @default.
- W2085655123 countsByYear W20856551232017 @default.
- W2085655123 countsByYear W20856551232018 @default.
- W2085655123 countsByYear W20856551232019 @default.
- W2085655123 countsByYear W20856551232021 @default.
- W2085655123 countsByYear W20856551232022 @default.
- W2085655123 crossrefType "journal-article" @default.
- W2085655123 hasAuthorship W2085655123A5015229978 @default.
- W2085655123 hasAuthorship W2085655123A5019320217 @default.
- W2085655123 hasAuthorship W2085655123A5024403470 @default.
- W2085655123 hasAuthorship W2085655123A5044475923 @default.
- W2085655123 hasAuthorship W2085655123A5044882291 @default.
- W2085655123 hasAuthorship W2085655123A5049894537 @default.
- W2085655123 hasAuthorship W2085655123A5064220321 @default.
- W2085655123 hasAuthorship W2085655123A5083633703 @default.
- W2085655123 hasAuthorship W2085655123A5091230903 @default.
- W2085655123 hasBestOaLocation W20856551231 @default.
- W2085655123 hasConcept C104317684 @default.
- W2085655123 hasConcept C126322002 @default.
- W2085655123 hasConcept C134018914 @default.
- W2085655123 hasConcept C145103041 @default.
- W2085655123 hasConcept C16685009 @default.
- W2085655123 hasConcept C172680121 @default.
- W2085655123 hasConcept C182704531 @default.
- W2085655123 hasConcept C2776953305 @default.