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• W2085655283 abstract "Nitric oxide synthase (NOS), an important bioregulator of a variety of biological processes, is overexpressed in colonic tumors of humans and rodents. In this study, effects of L-N(G)-nitroarginine methyl ester (L-NAME), a NOS inhibitor, on development of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in F344 male rats were investigated. Six-week-old male F344 rats were fed diets containing 0 or 100 ppm L-NAME, and given s.c. injections of AOM at 15 mg/kg body wt, once a week for 2 weeks. At 17 weeks of age, all animals were sacrificed and their colons were evaluated for numbers of ACF. Feeding of 100 ppm L-NAME inhibited the development of ACF in different sizes by 24-39%, those containing four or more crypts being most markedly affected. Assessment of silver-stained nucleolar organizer regions protein (AgNORs)/nucleus further revealed a 44% reduction by administration of L-NAME. These results suggest that the NOS inhibitor, L-NAME, may be an effective chemopreventive agent against colon carcinogenesis due to depression of cell proliferation." @default.
• W2085655283 created "2016-06-24" @default.
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• W2085655283 date "2000-01-01" @default.
• W2085655283 modified "2023-10-01" @default.
• W2085655283 title "Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor" @default.
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• W2085655283 doi "https://doi.org/10.1016/s0304-3835(99)00310-9" @default.
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