FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085657232> ?p ?o ?g. }

• W2085657232 endingPage "24" @default.
• W2085657232 startingPage "18" @default.
• W2085657232 abstract "Natural killer (NK) cells are our initial immune defense against viral infections and cancer development. They are able to destroy tumor and virally infected cells. Thus, agents that are able to interfere with their function increase the risk of cancer and/or infection. Organotins (OTs) have been shown to interfere with the tumor-destroying function of human NK cells. The purpose of the current study was to explore the relationship of a series of triorganotins, that differ in structure by only a single organic group, for their capacity to block NK tumor-cell destroying (lytic) function. Here we examine the series: trimethyltin (TMT), dimethylphenyltin (DMPT), methyldiphenyltin (MDPT), and triphenyltin (TPT). NK cells were exposed to TMT, DMPT, MDPT or TPT for 1, 24, 48h, or 6d. A 1h exposure to TMT, at concentrations as high as 20μM, had no effect on lytic function. However, concentrations as low as 2.5μM were able to decrease NK tumor-destroying function after 6d. A 1h exposure to DMPT had no effect on lytic function, however, after 6d there was an 80-90% decrease in lytic function at 1μM. Exposure to MDPT (as low as 2.5μM) decreased NK function at 1h, after 6d there was as much as a 90% decrease at concentrations as low as 100nM MDPT. TPT decreased lytic function in a manner similar to MDPT, however, it was more effective at 1h than MDPT. The effect of the triorganotins on the ability of NK cells to bind to targets was studied, to determine if this contributed to the loss of lytic function. The relative immunotoxic potential of this series of compounds is TPT≈MDPT>DMPT>TMT." @default.
• W2085657232 created "2016-06-24" @default.
• W2085657232 creator A5013337548 @default.
• W2085657232 creator A5023539152 @default.
• W2085657232 creator A5050212067 @default.
• W2085657232 creator A5087082314 @default.
• W2085657232 creator A5090757520 @default.
• W2085657232 date "2007-01-01" @default.
• W2085657232 modified "2023-09-27" @default.
• W2085657232 title "Effect of a series of triorganotins on the immune function of human natural killer cells" @default.
• W2085657232 cites W120605627 @default.
• W2085657232 cites W1970166627 @default.
• W2085657232 cites W1980494908 @default.
• W2085657232 cites W1985958471 @default.
• W2085657232 cites W1990034411 @default.
• W2085657232 cites W1997087758 @default.
• W2085657232 cites W2001821223 @default.
• W2085657232 cites W2008221423 @default.
• W2085657232 cites W2012385787 @default.
• W2085657232 cites W2013700589 @default.
• W2085657232 cites W2017653001 @default.
• W2085657232 cites W2025014144 @default.
• W2085657232 cites W2033225464 @default.
• W2085657232 cites W2035917266 @default.
• W2085657232 cites W2036823999 @default.
• W2085657232 cites W2040682268 @default.
• W2085657232 cites W2042692959 @default.
• W2085657232 cites W2049209352 @default.
• W2085657232 cites W2049823228 @default.
• W2085657232 cites W2058544142 @default.
• W2085657232 cites W2063709533 @default.
• W2085657232 cites W2065060106 @default.
• W2085657232 cites W2070871702 @default.
• W2085657232 cites W2075660527 @default.
• W2085657232 cites W2076214201 @default.
• W2085657232 cites W2078978055 @default.
• W2085657232 cites W2086589940 @default.
• W2085657232 cites W2087141513 @default.
• W2085657232 cites W2096113759 @default.
• W2085657232 cites W2114948126 @default.
• W2085657232 cites W2120554472 @default.
• W2085657232 cites W2123159968 @default.
• W2085657232 cites W2126920933 @default.
• W2085657232 cites W2148752634 @default.
• W2085657232 cites W2151723746 @default.
• W2085657232 cites W2172022269 @default.
• W2085657232 cites W2235434166 @default.
• W2085657232 cites W2460404930 @default.
• W2085657232 cites W2903867651 @default.
• W2085657232 cites W4234313505 @default.
• W2085657232 cites W51471118 @default.
• W2085657232 doi "https://doi.org/10.1016/j.etap.2006.06.001" @default.
• W2085657232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21783732" @default.
• W2085657232 hasPublicationYear "2007" @default.
• W2085657232 type Work @default.
• W2085657232 sameAs 2085657232 @default.
• W2085657232 citedByCount "28" @default.
• W2085657232 countsByYear W20856572322012 @default.
• W2085657232 countsByYear W20856572322013 @default.
• W2085657232 countsByYear W20856572322014 @default.
• W2085657232 countsByYear W20856572322016 @default.
• W2085657232 countsByYear W20856572322017 @default.
• W2085657232 countsByYear W20856572322018 @default.
• W2085657232 countsByYear W20856572322019 @default.
• W2085657232 countsByYear W20856572322020 @default.
• W2085657232 countsByYear W20856572322021 @default.
• W2085657232 countsByYear W20856572322022 @default.
• W2085657232 crossrefType "journal-article" @default.
• W2085657232 hasAuthorship W2085657232A5013337548 @default.
• W2085657232 hasAuthorship W2085657232A5023539152 @default.
• W2085657232 hasAuthorship W2085657232A5050212067 @default.
• W2085657232 hasAuthorship W2085657232A5087082314 @default.
• W2085657232 hasAuthorship W2085657232A5090757520 @default.
• W2085657232 hasConcept C109316439 @default.
• W2085657232 hasConcept C14036430 @default.
• W2085657232 hasConcept C153911025 @default.
• W2085657232 hasConcept C182615771 @default.
• W2085657232 hasConcept C185592680 @default.
• W2085657232 hasConcept C202751555 @default.
• W2085657232 hasConcept C203014093 @default.
• W2085657232 hasConcept C2522874641 @default.
• W2085657232 hasConcept C2778102761 @default.
• W2085657232 hasConcept C55493867 @default.
• W2085657232 hasConcept C86803240 @default.
• W2085657232 hasConcept C8891405 @default.
• W2085657232 hasConcept C95444343 @default.
• W2085657232 hasConceptScore W2085657232C109316439 @default.
• W2085657232 hasConceptScore W2085657232C14036430 @default.
• W2085657232 hasConceptScore W2085657232C153911025 @default.
• W2085657232 hasConceptScore W2085657232C182615771 @default.
• W2085657232 hasConceptScore W2085657232C185592680 @default.
• W2085657232 hasConceptScore W2085657232C202751555 @default.
• W2085657232 hasConceptScore W2085657232C203014093 @default.
• W2085657232 hasConceptScore W2085657232C2522874641 @default.
• W2085657232 hasConceptScore W2085657232C2778102761 @default.
• W2085657232 hasConceptScore W2085657232C55493867 @default.
• W2085657232 hasConceptScore W2085657232C86803240 @default.
• W2085657232 hasConceptScore W2085657232C8891405 @default.

• next