FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085658437> ?p ?o ?g. }

• W2085658437 endingPage "507" @default.
• W2085658437 startingPage "499" @default.
• W2085658437 abstract "The purpose of this study was to investigate, within the context of the Danish Breast Cancer Cooperative Group (DBCG) programmes, whether a dedicated surgical approach had a significant bearing on the outcome of breast cancer treatment.From 1 January 1980 to 31 December 1990, patients below 70 years of age with operable breast cancer from Odense University Hospital (n=743) were compared with those from the rest of Denmark (denoted rest-DK) (n=15,419). All patients were treated according to nationwide DBCG guidelines and reported to the DBCG Data Centre. The potential median observation time was 11.2 years (range 6.0-16.9). Patients underwent mastectomy or breast conserving therapy, and high risk lymph-node positive patients had adjuvant systemic therapy with or without radiotherapy.Comparing total patients series, overall survival (OS) was significantly superior in patients from Odense compared with rest-DK (P=0.02), with 10-year OSs of 62% (95% CI: 58-65%) and 56% (55-57%), respectively. In subgroups, the OS of low-risk node negative patients (protocol A) in Odense compared with rest-DK was significantly better (P=0.02); 10-year OS was 78% (73-84%) versus 72% (70-73%). Among the high-risk pre-menopausal patients (protocol B), the OS was significantly better in Odense (P=0.009); 10-year OS was 67% (60-75%) versus 53% (51-55%) in rest-DK. Post-menopausal high-risk patients (protocol C) did not differ significantly in OS between Odense and rest-DK (P=0.61). Locoregional control in the Odense series was superior compared with rest-DK. More lymph nodes were recovered and examined from the axilla in the Odense series than in rest-DK, a median of 10 vs. 6 nodes. In the Odense series, a significantly higher proportion of pre-menopausal patients had positive lymph nodes, predominantly one to three positive nodes, and subsequently a lower proportion of pre-menopausal patients had negative lymph nodes compared with rest-DK (P=0.02), indicating a more accurate staging in Odense vs. rest-DK. The survival benefit among the patients from Odense cannot be explained by stage migration alone, but seems to represent a true survival advantage. Overall mortality was significantly lower in the Odense series compared with rest-DK. Whether or not this difference could be explained by lower background mortality in the Odense series or was caused by superior treatment is discussed.The extent of surgery seems important for locoregional tumour control and accurate axillary lymph-node staging. In combination, these might lead to superior recurrence-free and overall survival, although differences in background mortality cannot be ignored. Surgery, therefore, might represent a risk factor by itself." @default.
• W2085658437 created "2016-06-24" @default.
• W2085658437 creator A5010640182 @default.
• W2085658437 creator A5017888674 @default.
• W2085658437 creator A5020344311 @default.
• W2085658437 creator A5028367220 @default.
• W2085658437 creator A5029098621 @default.
• W2085658437 creator A5040685980 @default.
• W2085658437 creator A5071906982 @default.
• W2085658437 creator A5076400896 @default.
• W2085658437 creator A5087063714 @default.
• W2085658437 date "1998-12-01" @default.
• W2085658437 modified "2023-10-18" @default.
• W2085658437 title "The importance of surgery and accurate axillary staging for survival in breast cancer" @default.
• W2085658437 cites W1562190372 @default.
• W2085658437 cites W1588531227 @default.
• W2085658437 cites W1973822018 @default.
• W2085658437 cites W1978923583 @default.
• W2085658437 cites W1986724196 @default.
• W2085658437 cites W1987424181 @default.
• W2085658437 cites W1994348671 @default.
• W2085658437 cites W2003379094 @default.
• W2085658437 cites W2003968170 @default.
• W2085658437 cites W2008586604 @default.
• W2085658437 cites W2017509580 @default.
• W2085658437 cites W2028416818 @default.
• W2085658437 cites W2031695672 @default.
• W2085658437 cites W2036934183 @default.
• W2085658437 cites W2045780073 @default.
• W2085658437 cites W2060091591 @default.
• W2085658437 cites W2091033401 @default.
• W2085658437 cites W2125568763 @default.
• W2085658437 cites W2140249540 @default.
• W2085658437 cites W2332829713 @default.
• W2085658437 cites W2396425189 @default.
• W2085658437 cites W2411797757 @default.
• W2085658437 cites W2414823819 @default.
• W2085658437 cites W2426386028 @default.
• W2085658437 cites W2430549984 @default.
• W2085658437 cites W267005183 @default.
• W2085658437 cites W2970020807 @default.
• W2085658437 cites W2982331347 @default.
• W2085658437 cites W301780982 @default.
• W2085658437 cites W92766923 @default.
• W2085658437 doi "https://doi.org/10.1016/s0748-7983(98)93320-0" @default.
• W2085658437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9870724" @default.
• W2085658437 hasPublicationYear "1998" @default.
• W2085658437 type Work @default.
• W2085658437 sameAs 2085658437 @default.
• W2085658437 citedByCount "16" @default.
• W2085658437 countsByYear W20856584372017 @default.
• W2085658437 countsByYear W20856584372020 @default.
• W2085658437 crossrefType "journal-article" @default.
• W2085658437 hasAuthorship W2085658437A5010640182 @default.
• W2085658437 hasAuthorship W2085658437A5017888674 @default.
• W2085658437 hasAuthorship W2085658437A5020344311 @default.
• W2085658437 hasAuthorship W2085658437A5028367220 @default.
• W2085658437 hasAuthorship W2085658437A5029098621 @default.
• W2085658437 hasAuthorship W2085658437A5040685980 @default.
• W2085658437 hasAuthorship W2085658437A5071906982 @default.
• W2085658437 hasAuthorship W2085658437A5076400896 @default.
• W2085658437 hasAuthorship W2085658437A5087063714 @default.
• W2085658437 hasConcept C121608353 @default.
• W2085658437 hasConcept C126322002 @default.
• W2085658437 hasConcept C138885662 @default.
• W2085658437 hasConcept C141071460 @default.
• W2085658437 hasConcept C151730666 @default.
• W2085658437 hasConcept C164622146 @default.
• W2085658437 hasConcept C2777757722 @default.
• W2085658437 hasConcept C2779343474 @default.
• W2085658437 hasConcept C2780849966 @default.
• W2085658437 hasConcept C29456083 @default.
• W2085658437 hasConcept C41895202 @default.
• W2085658437 hasConcept C509974204 @default.
• W2085658437 hasConcept C530470458 @default.
• W2085658437 hasConcept C71924100 @default.
• W2085658437 hasConcept C77265313 @default.
• W2085658437 hasConcept C86803240 @default.
• W2085658437 hasConceptScore W2085658437C121608353 @default.
• W2085658437 hasConceptScore W2085658437C126322002 @default.
• W2085658437 hasConceptScore W2085658437C138885662 @default.
• W2085658437 hasConceptScore W2085658437C141071460 @default.
• W2085658437 hasConceptScore W2085658437C151730666 @default.
• W2085658437 hasConceptScore W2085658437C164622146 @default.
• W2085658437 hasConceptScore W2085658437C2777757722 @default.
• W2085658437 hasConceptScore W2085658437C2779343474 @default.
• W2085658437 hasConceptScore W2085658437C2780849966 @default.
• W2085658437 hasConceptScore W2085658437C29456083 @default.
• W2085658437 hasConceptScore W2085658437C41895202 @default.
• W2085658437 hasConceptScore W2085658437C509974204 @default.
• W2085658437 hasConceptScore W2085658437C530470458 @default.
• W2085658437 hasConceptScore W2085658437C71924100 @default.
• W2085658437 hasConceptScore W2085658437C77265313 @default.
• W2085658437 hasConceptScore W2085658437C86803240 @default.
• W2085658437 hasIssue "6" @default.
• W2085658437 hasLocation W20856584371 @default.
• W2085658437 hasLocation W20856584372 @default.
• W2085658437 hasOpenAccess W2085658437 @default.

• next