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- W2085666547 abstract "A patient is described who developed symptoms of paroxysmal nocturnal hemoglobinuria (PNH) in her first pregnancy. This was uneventful except for a spontaneous preterm delivery. The second pregnancy was complicated by severe anemia and a hemolytic crisis with Budd-Chiari syndrome at 31 weeks' amenorrhoea. Delivery was again preterm and was the result of induced labour after premature rupture of membranes at 34 weeks. Literature shows a high maternal mortality among PNH patients (5.8%). The most common cause of death is liver vein thrombosis (Budd-Chiari syndrome). Fetal wastage (30%) and prematurity rate (16%) are also high. Recommendations for follow-up and therapy are given such as anticoagulation therapy, platelets and washed erythocytes transfusions, screening for Budd-Chiari syndrome and infections." @default.
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- W2085666547 date "1994-03-01" @default.
- W2085666547 modified "2023-09-25" @default.
- W2085666547 title "Pregnancy and paroxysmal nocturnal hemoglobinuria" @default.
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- W2085666547 doi "https://doi.org/10.1016/0028-2243(94)90121-x" @default.
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