Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085668827> ?p ?o ?g. }
- W2085668827 endingPage "3104" @default.
- W2085668827 startingPage "3097" @default.
- W2085668827 abstract "The neonatal ventral hippocampal lesion in the rat has been used as a model of schizophrenia, a human disorder associated with changes in markers of dopamine and γ-aminobutyric acid (GABA) circuits in various regions of the brain. We investigated whether alterations in mRNA markers related to the activity of midbrain dopaminergic and GABAergic neurons are associated with this model. We used in situ hybridization histochemistry to assess expression of mRNAs for dopamine transporter (DAT), tyrosine hydroxylase (TH) and glutamate decarboxylase-67 (GAD67) in the midbrain of adult rats with neonatal and adult ibotenic acid lesions of the ventral hippocampus. Neonatally lesioned rats showed in adulthood significantly reduced expression of DAT mRNA in the substantia nigra and the ventral tegmental area but no changes in the expression of TH and GAD67 mRNAs in these midbrain regions. Adult lesioned rats showed no changes in the expression of any of these genes. As the neonatal ventral hippocampal lesion reproduces many aspects of schizophrenia and is used as an animal model of this disorder, these results suggest that the reduction in DAT mRNA could result from developmental neuropathology in the ventral hippocampus and may thus represent a molecular substrate of the disease process." @default.
- W2085668827 created "2016-06-24" @default.
- W2085668827 creator A5019454319 @default.
- W2085668827 creator A5024978421 @default.
- W2085668827 creator A5043264677 @default.
- W2085668827 creator A5054945238 @default.
- W2085668827 date "2003-12-01" @default.
- W2085668827 modified "2023-10-17" @default.
- W2085668827 title "The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain" @default.
- W2085668827 cites W1515432410 @default.
- W2085668827 cites W1567533370 @default.
- W2085668827 cites W1616315782 @default.
- W2085668827 cites W1768956672 @default.
- W2085668827 cites W1882365212 @default.
- W2085668827 cites W1895466054 @default.
- W2085668827 cites W1963591746 @default.
- W2085668827 cites W1964240411 @default.
- W2085668827 cites W1968013284 @default.
- W2085668827 cites W1975682905 @default.
- W2085668827 cites W1975723323 @default.
- W2085668827 cites W1983985508 @default.
- W2085668827 cites W1999943185 @default.
- W2085668827 cites W2001311556 @default.
- W2085668827 cites W2002092502 @default.
- W2085668827 cites W2004425853 @default.
- W2085668827 cites W2005432794 @default.
- W2085668827 cites W2010174773 @default.
- W2085668827 cites W2012245779 @default.
- W2085668827 cites W2012955582 @default.
- W2085668827 cites W2013622904 @default.
- W2085668827 cites W2014793858 @default.
- W2085668827 cites W2016519537 @default.
- W2085668827 cites W2020502982 @default.
- W2085668827 cites W2026784815 @default.
- W2085668827 cites W2027204610 @default.
- W2085668827 cites W2028365402 @default.
- W2085668827 cites W2031008496 @default.
- W2085668827 cites W2034821677 @default.
- W2085668827 cites W2036812929 @default.
- W2085668827 cites W2040181871 @default.
- W2085668827 cites W2044533253 @default.
- W2085668827 cites W2062251624 @default.
- W2085668827 cites W2072060777 @default.
- W2085668827 cites W2072621056 @default.
- W2085668827 cites W2080423091 @default.
- W2085668827 cites W2083876585 @default.
- W2085668827 cites W2084909071 @default.
- W2085668827 cites W2085875247 @default.
- W2085668827 cites W2092246706 @default.
- W2085668827 cites W2096316302 @default.
- W2085668827 cites W2097300084 @default.
- W2085668827 cites W2113631648 @default.
- W2085668827 cites W2124796879 @default.
- W2085668827 cites W2126060120 @default.
- W2085668827 cites W2134340301 @default.
- W2085668827 cites W2139358036 @default.
- W2085668827 cites W2141831574 @default.
- W2085668827 cites W2142732083 @default.
- W2085668827 cites W2150299732 @default.
- W2085668827 cites W215048894 @default.
- W2085668827 cites W2154169426 @default.
- W2085668827 cites W2157092444 @default.
- W2085668827 cites W4239507418 @default.
- W2085668827 cites W4253486355 @default.
- W2085668827 doi "https://doi.org/10.1111/j.1460-9568.2003.03047.x" @default.
- W2085668827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14656305" @default.
- W2085668827 hasPublicationYear "2003" @default.
- W2085668827 type Work @default.
- W2085668827 sameAs 2085668827 @default.
- W2085668827 citedByCount "74" @default.
- W2085668827 countsByYear W20856688272012 @default.
- W2085668827 countsByYear W20856688272013 @default.
- W2085668827 countsByYear W20856688272014 @default.
- W2085668827 countsByYear W20856688272015 @default.
- W2085668827 countsByYear W20856688272016 @default.
- W2085668827 countsByYear W20856688272017 @default.
- W2085668827 countsByYear W20856688272020 @default.
- W2085668827 countsByYear W20856688272021 @default.
- W2085668827 countsByYear W20856688272023 @default.
- W2085668827 crossrefType "journal-article" @default.
- W2085668827 hasAuthorship W2085668827A5019454319 @default.
- W2085668827 hasAuthorship W2085668827A5024978421 @default.
- W2085668827 hasAuthorship W2085668827A5043264677 @default.
- W2085668827 hasAuthorship W2085668827A5054945238 @default.
- W2085668827 hasConcept C104317684 @default.
- W2085668827 hasConcept C105580179 @default.
- W2085668827 hasConcept C126322002 @default.
- W2085668827 hasConcept C134018914 @default.
- W2085668827 hasConcept C137183658 @default.
- W2085668827 hasConcept C148762608 @default.
- W2085668827 hasConcept C159167319 @default.
- W2085668827 hasConcept C169760540 @default.
- W2085668827 hasConcept C17077164 @default.
- W2085668827 hasConcept C181199279 @default.
- W2085668827 hasConcept C2776755682 @default.
- W2085668827 hasConcept C2779177108 @default.
- W2085668827 hasConcept C2780938664 @default.
- W2085668827 hasConcept C2780948874 @default.