Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085673399> ?p ?o ?g. }
- W2085673399 endingPage "2017" @default.
- W2085673399 startingPage "2008" @default.
- W2085673399 abstract "The identification of glomerular auto-antigens in idiopathic human membranous glomerulonephritis (MGN) is a crucial step towards the definition of the mechanisms of the disease. Recent 'in vivo' studies demonstrated a heterogeneous composition of glomerular immune-deposits in MGN biopsies only a part of which have been characterized. We studied with a proteomical approach IgGs eluted from laser capture microdissected glomeruli of 8 MGN patients and showed the existence of other three immune proteins in MGN glomeruli (α-enolase, elongation factor 2 and Glycyl Aminoacyl-tRNA Synthetase). One of these, i.e. α-enolase, fulfilled all criteria for being considered an auto-antigen. Specific IgG₁ and IgG₄ reacting with podocyte α-enolase were, in fact, eluted from microdissected glomeruli and Confocal- and Immuno Electron-Microscopy showed co-localization of α-enolase with IgG₄ and C5b-9 in immune-deposits. Serum levels of anti a-enolase IgG4 were determined in 131 MGN patients and were found elevated in 25% of cases. Overall, our data demonstrate that glomerular α-enolase is a target antigen of autoimmunity in human MGN. Circulating anti α-enolase auto-antibodies can be detected in sera of a significant quota of MGN patients. Like other auto-antigens, α-enolase may be implicated in the pathogenesis of human MGN." @default.
- W2085673399 created "2016-06-24" @default.
- W2085673399 creator A5001391327 @default.
- W2085673399 creator A5003127217 @default.
- W2085673399 creator A5009974503 @default.
- W2085673399 creator A5010022331 @default.
- W2085673399 creator A5011126676 @default.
- W2085673399 creator A5020775570 @default.
- W2085673399 creator A5039683551 @default.
- W2085673399 creator A5041508639 @default.
- W2085673399 creator A5047266922 @default.
- W2085673399 creator A5047786318 @default.
- W2085673399 creator A5065434686 @default.
- W2085673399 creator A5067081469 @default.
- W2085673399 creator A5083711626 @default.
- W2085673399 creator A5089308828 @default.
- W2085673399 creator A5090372922 @default.
- W2085673399 date "2011-09-01" @default.
- W2085673399 modified "2023-09-29" @default.
- W2085673399 title "Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigens" @default.
- W2085673399 cites W1571207214 @default.
- W2085673399 cites W1967908761 @default.
- W2085673399 cites W1970092281 @default.
- W2085673399 cites W1976941367 @default.
- W2085673399 cites W1979672613 @default.
- W2085673399 cites W1986167294 @default.
- W2085673399 cites W1987559400 @default.
- W2085673399 cites W1995810724 @default.
- W2085673399 cites W2007190848 @default.
- W2085673399 cites W2014538635 @default.
- W2085673399 cites W2019010500 @default.
- W2085673399 cites W2020616739 @default.
- W2085673399 cites W2027354239 @default.
- W2085673399 cites W2029198423 @default.
- W2085673399 cites W2033472578 @default.
- W2085673399 cites W2034094016 @default.
- W2085673399 cites W2042314261 @default.
- W2085673399 cites W2045220097 @default.
- W2085673399 cites W2046726975 @default.
- W2085673399 cites W2066762078 @default.
- W2085673399 cites W2072893670 @default.
- W2085673399 cites W2087949876 @default.
- W2085673399 cites W2097573588 @default.
- W2085673399 cites W2100837269 @default.
- W2085673399 cites W2106440646 @default.
- W2085673399 cites W2111285312 @default.
- W2085673399 cites W2120467386 @default.
- W2085673399 cites W2124211877 @default.
- W2085673399 cites W2134252312 @default.
- W2085673399 cites W2138543166 @default.
- W2085673399 cites W2140538253 @default.
- W2085673399 cites W2149858671 @default.
- W2085673399 cites W2150591757 @default.
- W2085673399 cites W2154852379 @default.
- W2085673399 cites W2166822765 @default.
- W2085673399 doi "https://doi.org/10.1016/j.jprot.2011.05.021" @default.
- W2085673399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21640210" @default.
- W2085673399 hasPublicationYear "2011" @default.
- W2085673399 type Work @default.
- W2085673399 sameAs 2085673399 @default.
- W2085673399 citedByCount "103" @default.
- W2085673399 countsByYear W20856733992012 @default.
- W2085673399 countsByYear W20856733992013 @default.
- W2085673399 countsByYear W20856733992014 @default.
- W2085673399 countsByYear W20856733992015 @default.
- W2085673399 countsByYear W20856733992016 @default.
- W2085673399 countsByYear W20856733992017 @default.
- W2085673399 countsByYear W20856733992018 @default.
- W2085673399 countsByYear W20856733992019 @default.
- W2085673399 countsByYear W20856733992020 @default.
- W2085673399 countsByYear W20856733992021 @default.
- W2085673399 countsByYear W20856733992022 @default.
- W2085673399 countsByYear W20856733992023 @default.
- W2085673399 crossrefType "journal-article" @default.
- W2085673399 hasAuthorship W2085673399A5001391327 @default.
- W2085673399 hasAuthorship W2085673399A5003127217 @default.
- W2085673399 hasAuthorship W2085673399A5009974503 @default.
- W2085673399 hasAuthorship W2085673399A5010022331 @default.
- W2085673399 hasAuthorship W2085673399A5011126676 @default.
- W2085673399 hasAuthorship W2085673399A5020775570 @default.
- W2085673399 hasAuthorship W2085673399A5039683551 @default.
- W2085673399 hasAuthorship W2085673399A5041508639 @default.
- W2085673399 hasAuthorship W2085673399A5047266922 @default.
- W2085673399 hasAuthorship W2085673399A5047786318 @default.
- W2085673399 hasAuthorship W2085673399A5065434686 @default.
- W2085673399 hasAuthorship W2085673399A5067081469 @default.
- W2085673399 hasAuthorship W2085673399A5083711626 @default.
- W2085673399 hasAuthorship W2085673399A5089308828 @default.
- W2085673399 hasAuthorship W2085673399A5090372922 @default.
- W2085673399 hasConcept C134018914 @default.
- W2085673399 hasConcept C142724271 @default.
- W2085673399 hasConcept C147483822 @default.
- W2085673399 hasConcept C153911025 @default.
- W2085673399 hasConcept C159654299 @default.
- W2085673399 hasConcept C185592680 @default.
- W2085673399 hasConcept C188618488 @default.
- W2085673399 hasConcept C203014093 @default.
- W2085673399 hasConcept C204232928 @default.