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- W2085674191 abstract "[ABSTRACT] Although many fibrinolytic agents have been developed and used for clinical purposes, thromboembolic diseases remain the leading cause of adult morbidity and mortality in the world. Developing effective agents for clinical application from various unusual animal species has received more attention in recent years. A group of fibrinolytic enzymes named earthworm fibrinolytic enzyme (EFE) and secreted by the alimentary tract of earthworm, have exhibited excellent potential in the clinical treatment of blood clotting diseases. It is therefore useful to build up some correlations with the data available in order to better explore the molecular and cellular mechanism of EFE action in the treatment of diseases. The aspects discussed include: the purification, characterization, gene cloning and expression, structure and function as well as clinical application of the EFEs. This review focuses on recent advances in molecular and cellular mechanisms of EFE action and the structure activity relationship. [KEY WORDS] Earthworm fibrinolytic enzyme (EFE); Thrombolytic agent [CLC Number] Q55 [Document code] A [Article ID] 1672-3651(2010)04-0301-08 doi: 10.3724/SP. J. 1009.2010.00301" @default.
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- W2085674191 date "2010-08-05" @default.
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- W2085674191 title "An Overview of the Fibrinolytic Enzyme from Earth-worm" @default.
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