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• W2085676054 endingPage "35701" @default.
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• W2085676054 abstract "Stimulation of human dendritic cells with the fungal surrogate zymosan produces IL-23 and a low amount of IL-12 p70. Trans-repression of il12a transcription, which encodes IL-12 p35 chain, by proteins of the Notch family and lysine deacetylation reactions have been reported as the underlying mechanisms, but a number of questions remain to be addressed. Zymosan produced the location of sirtuin 1 (SIRT1) to the nucleus, enhanced its association with the il12a promoter, increased the nuclear concentration of the SIRT1 co-substrate NAD+, and decreased chromatin accessibility in the nucleosome-1 of il12a, which contains a κB-site. The involvement of deacetylation reactions in the inhibition of il12a transcription was supported by the absence of Ac-Lys-14-histone H3 in dendritic cells treated with zymosan upon coimmunoprecipitation of transducin-like enhancer of split. In contrast, we did not obtain evidence of a possible effect of SIRT1 through the deacetylation of c-Rel, the central element of the NF-κB family involved in il12a regulation. These data indicate that an enhancement of SIRT1 activity in response to phagocytic stimuli may reduce the accessibility of c-Rel to the il12a promoter and its transcriptional activation, thus regulating the IL-12 p70/IL-23 balance and modulating the ongoing immune response. Stimulation of human dendritic cells with the fungal surrogate zymosan produces IL-23 and a low amount of IL-12 p70. Trans-repression of il12a transcription, which encodes IL-12 p35 chain, by proteins of the Notch family and lysine deacetylation reactions have been reported as the underlying mechanisms, but a number of questions remain to be addressed. Zymosan produced the location of sirtuin 1 (SIRT1) to the nucleus, enhanced its association with the il12a promoter, increased the nuclear concentration of the SIRT1 co-substrate NAD+, and decreased chromatin accessibility in the nucleosome-1 of il12a, which contains a κB-site. The involvement of deacetylation reactions in the inhibition of il12a transcription was supported by the absence of Ac-Lys-14-histone H3 in dendritic cells treated with zymosan upon coimmunoprecipitation of transducin-like enhancer of split. In contrast, we did not obtain evidence of a possible effect of SIRT1 through the deacetylation of c-Rel, the central element of the NF-κB family involved in il12a regulation. These data indicate that an enhancement of SIRT1 activity in response to phagocytic stimuli may reduce the accessibility of c-Rel to the il12a promoter and its transcriptional activation, thus regulating the IL-12 p70/IL-23 balance and modulating the ongoing immune response." @default.
• W2085676054 created "2016-06-24" @default.
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• W2085676054 date "2012-10-01" @default.
• W2085676054 modified "2023-10-02" @default.
• W2085676054 title "Sirtuin 1 Is a Key Regulator of the Interleukin-12 p70/Interleukin-23 Balance in Human Dendritic Cells" @default.
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• W2085676054 cites W1610489281 @default.
• W2085676054 cites W1968687456 @default.
• W2085676054 cites W1971037507 @default.
• W2085676054 cites W1974890383 @default.
• W2085676054 cites W1975598191 @default.
• W2085676054 cites W1978779470 @default.
• W2085676054 cites W1985371834 @default.
• W2085676054 cites W1988495967 @default.
• W2085676054 cites W1990174038 @default.
• W2085676054 cites W1993260214 @default.
• W2085676054 cites W1994158191 @default.
• W2085676054 cites W2001016183 @default.
• W2085676054 cites W2004335766 @default.
• W2085676054 cites W2006173503 @default.
• W2085676054 cites W2006470470 @default.
• W2085676054 cites W2008776460 @default.
• W2085676054 cites W2014631569 @default.
• W2085676054 cites W2019080454 @default.
• W2085676054 cites W2022267544 @default.
• W2085676054 cites W2031202094 @default.
• W2085676054 cites W2041098309 @default.
• W2085676054 cites W2045442669 @default.
• W2085676054 cites W2047265080 @default.
• W2085676054 cites W2050253122 @default.
• W2085676054 cites W2052041317 @default.
• W2085676054 cites W2052572393 @default.
• W2085676054 cites W2053213876 @default.
• W2085676054 cites W2055906772 @default.
• W2085676054 cites W2063084036 @default.
• W2085676054 cites W2067938485 @default.
• W2085676054 cites W2070383733 @default.
• W2085676054 cites W2072528578 @default.
• W2085676054 cites W2076889715 @default.
• W2085676054 cites W2080767267 @default.
• W2085676054 cites W2086524434 @default.
• W2085676054 cites W2096049596 @default.
• W2085676054 cites W2097042870 @default.
• W2085676054 cites W2097903739 @default.
• W2085676054 cites W2097948853 @default.
• W2085676054 cites W2098365610 @default.
• W2085676054 cites W2106519587 @default.
• W2085676054 cites W2109061188 @default.
• W2085676054 cites W2109724505 @default.
• W2085676054 cites W2110271190 @default.
• W2085676054 cites W2111219358 @default.
• W2085676054 cites W2116828514 @default.
• W2085676054 cites W2117411862 @default.
• W2085676054 cites W2117674849 @default.
• W2085676054 cites W2117817795 @default.
• W2085676054 cites W2122481751 @default.
• W2085676054 cites W2123257376 @default.
• W2085676054 cites W2129224427 @default.
• W2085676054 cites W2133657961 @default.
• W2085676054 cites W2135218342 @default.
• W2085676054 cites W2135711139 @default.
• W2085676054 cites W2140925956 @default.
• W2085676054 cites W2141753982 @default.
• W2085676054 cites W2147497666 @default.
• W2085676054 cites W2152101492 @default.
• W2085676054 cites W2152748900 @default.
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• W2085676054 cites W2168268248 @default.
• W2085676054 cites W2169259762 @default.
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• W2085676054 doi "https://doi.org/10.1074/jbc.m112.391839" @default.
• W2085676054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3471763" @default.
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• W2085676054 hasPublicationYear "2012" @default.
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