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• W2085677130 abstract "In order to investigate diurnal variation in adenosine A1 receptors binding parameters, Bmax and Kd values of specifically bound N6 - cyclohexyl-[3H]adenosine were determined in the cerebral cortex of mice that had been housed under controlled light-dark cycles for 4 weeks (light on from 7.00 to 19.00 h). Significant differences were found for Bmax values measured at 3-hr intervals across a 24-h period, with low Bmax values during the light period and high Bmax values during the dark period. The amplitude between 03.00 and 18.00 hr was 33%. No substantial rhythm was found in the Kd values. It is suggested that the changes in the density of A1 receptors could reflect a physiologically-relevant mechanism by which adenosine exerts its modulatory role in the central nervous system." @default.
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• W2085677130 date "1991-01-01" @default.
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• W2085677130 title "Circadian rhythm in adenosine A1 receptor of mouse cerebral cortex" @default.
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• W2085677130 doi "https://doi.org/10.1016/0024-3205(91)90476-r" @default.
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