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• W2085677560 abstract "Numerous mutations in over 100 rod genes are the well-established cause of apoptotic death of these cells and development of night blindness in retinitis pigmentosa (RP). Cone death is either concomitant or follows rod death with resultant loss of critical peripheral and central day vision. As cones are generally not encumbered by genetic mutations, the causes of their death and its prevention are the central problems of RP research. Currently no FDA-approved medications are available for retarding RP progression.It is proposed that cones, which are outnumbered 20:1 by rods, undergo apoptosis as a consequence of neurotrophic factor deficiencies and oxidative stresses accompanying massive rod death: increased retinal oxygen tension; leakage of lipid-peroxidation catalysts from disrupted membranes; reactive oxygen species from active/hyperactive microglia ingesting rod-apoptotic bodies. Accordingly we developed and tested a treatment regimen with a range of antioxidants in combination with the off-label use of deprenyl (1 mg/day), a safe antiapoptotic agent, which also upregulates eight neurotrophic factors. Since deprenyl inhibits only one of four mitochondrial apoptotic pathways, we added the antibiotic minocycline (100 mg/day) to our protocol at month 76. Minocycline complements deprenyl's therapeutic properties: it inhibits all four apoptotic pathways; inhibits apoptosis-initiating proteins; as phenol exerts powerful antioxidant properties; upregulates three antioxidant enzymes; downregulates oxidative/inflammatory microglia activities. Its safe long-term use for acne and rheumatoid arthritis received FDA approval; it passes the blood/brain and blood/retinal barriers readily; and because of its rapid and complete absorption causes no intestinal disturbances. The National Eye Institute has initiated in 2010 and 2011 clinical trials with minocycline (200 mg/day) for diabetic macular edema and retinal branch vein occlusion.The hypothesis was tested for 140 months with one RP patient monitored by Humphrey Perimetry, which was quantitated by two parameters: (a) sum of decibel units, (b) number of detected light sources (visual field). Although no decline was observed in these parameters during the first 50 months of treatment, they declined by 10-28% during months 50-65. These declines reversed upon introduction of minocycline: over the total 140-month treatment, the right eye visual field showed 0% decline and left eye 13.3% decline. Rate constants for logarithmic decline of visual field measured prior to treatment indicate that visual fields would have decreased by 64% and 70%, respectively by month 140 in the absence of treatment." @default.
• W2085677560 created "2016-06-24" @default.
• W2085677560 creator A5052014599 @default.
• W2085677560 creator A5064391847 @default.
• W2085677560 date "2013-10-01" @default.
• W2085677560 modified "2023-09-25" @default.
• W2085677560 title "Rationale for an experimental treatment of retinitis pigmentosa: 140-Month test of hypothesis with one patient" @default.
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• W2085677560 cites W1536117213 @default.
• W2085677560 cites W161718591 @default.
• W2085677560 cites W1720856469 @default.
• W2085677560 cites W1966483924 @default.
• W2085677560 cites W1969510838 @default.
• W2085677560 cites W1973932342 @default.
• W2085677560 cites W1974007609 @default.
• W2085677560 cites W1980897236 @default.
• W2085677560 cites W1996037300 @default.
• W2085677560 cites W1998043586 @default.
• W2085677560 cites W2003222910 @default.
• W2085677560 cites W2003482600 @default.
• W2085677560 cites W2004349171 @default.
• W2085677560 cites W2005335651 @default.
• W2085677560 cites W2008468524 @default.
• W2085677560 cites W2012271461 @default.
• W2085677560 cites W2016429379 @default.
• W2085677560 cites W2018036141 @default.
• W2085677560 cites W2019964232 @default.
• W2085677560 cites W2022561792 @default.
• W2085677560 cites W2025329857 @default.
• W2085677560 cites W2028081504 @default.
• W2085677560 cites W2031532649 @default.
• W2085677560 cites W2034249851 @default.
• W2085677560 cites W2035326351 @default.
• W2085677560 cites W2037266034 @default.
• W2085677560 cites W2037934133 @default.
• W2085677560 cites W2040269004 @default.
• W2085677560 cites W2041077321 @default.
• W2085677560 cites W2043011906 @default.
• W2085677560 cites W2046895632 @default.
• W2085677560 cites W2047513253 @default.
• W2085677560 cites W2060952492 @default.
• W2085677560 cites W2067892235 @default.
• W2085677560 cites W2071355142 @default.
• W2085677560 cites W2074903431 @default.
• W2085677560 cites W2078285738 @default.
• W2085677560 cites W2080258263 @default.
• W2085677560 cites W2081838306 @default.
• W2085677560 cites W2081889973 @default.
• W2085677560 cites W2081945827 @default.
• W2085677560 cites W2086129284 @default.
• W2085677560 cites W2089919513 @default.
• W2085677560 cites W2090329118 @default.
• W2085677560 cites W2094166598 @default.
• W2085677560 cites W2096993232 @default.
• W2085677560 cites W2108645706 @default.
• W2085677560 cites W2114862320 @default.
• W2085677560 cites W2120113019 @default.
• W2085677560 cites W2120703680 @default.
• W2085677560 cites W2122276247 @default.
• W2085677560 cites W2126072121 @default.
• W2085677560 cites W2127150613 @default.
• W2085677560 cites W2133892931 @default.
• W2085677560 cites W2139636293 @default.
• W2085677560 cites W2150144089 @default.
• W2085677560 cites W2153111403 @default.
• W2085677560 cites W2156309047 @default.
• W2085677560 cites W2158335375 @default.
• W2085677560 cites W2158808781 @default.
• W2085677560 cites W2163260252 @default.
• W2085677560 cites W2169052828 @default.
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• W2085677560 cites W2409986472 @default.
• W2085677560 cites W2606163636 @default.
• W2085677560 cites W2892584183 @default.
• W2085677560 cites W32514316 @default.
• W2085677560 cites W2036278158 @default.
• W2085677560 doi "https://doi.org/10.1016/j.mehy.2013.07.036" @default.
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• W2085677560 hasPublicationYear "2013" @default.
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