FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085678065> ?p ?o ?g. }

• W2085678065 endingPage "1283" @default.
• W2085678065 startingPage "1277" @default.
• W2085678065 abstract "The P2X7 receptor is a bifunctional molecule. The binding of ATP induces within milliseconds the opening of a channel selective for small cations, and within seconds a larger pore opens which allows permeation by molecules as large as propidium dyes (629 Da). In situ hybridization using a digoxigeninlabelled riboprobe, and immunohistochemistry using an antibody raised against a C-terminal peptide sequence, were used to determine the distribution of the P2X7 receptor mRNA and protein in rat and mouse tissues and cell lines. The brain of newborn rats showed a 6 kb RNA by Northern blotting, but this was not detectable in adult brain. By in situ hybridization and immunohistochemistry, there was heavy labelling of ependymal cells in both newborn and adult brain, but the brain parenchyma showed no labelling. However, P2X7 receptor-immunoreactive cells appeared in the penumbral region around an area of necrosis evoked by prior occlusion of the middle cerebral artery, suggesting expression of the receptor by activated microglia. NTW8 cells, a mouse microglial cell line, strongly expressed the P2X7 receptor mRNA and protein. The P2X7 receptor mRNA and protein were also observed in the majority of bone marrow cells, including those separately identified by their expression of other antigens as granulocytes, monocyte/macrophages and B lymphocytes. The expression of P2X7 receptor by brain macrophages rather than neurons would be consistent with a role in brain repair following inflammation, infarction or immune insult." @default.
• W2085678065 created "2016-06-24" @default.
• W2085678065 creator A5033548247 @default.
• W2085678065 creator A5037029834 @default.
• W2085678065 creator A5042568915 @default.
• W2085678065 creator A5078972629 @default.
• W2085678065 creator A5084712627 @default.
• W2085678065 creator A5087332029 @default.
• W2085678065 date "1997-09-01" @default.
• W2085678065 modified "2023-10-13" @default.
• W2085678065 title "Tissue distribution of the P2X7 receptor" @default.
• W2085678065 cites W1488781666 @default.
• W2085678065 cites W1579992296 @default.
• W2085678065 cites W1582754633 @default.
• W2085678065 cites W1709464822 @default.
• W2085678065 cites W1775244163 @default.
• W2085678065 cites W1901115290 @default.
• W2085678065 cites W1947888345 @default.
• W2085678065 cites W1970613983 @default.
• W2085678065 cites W1977138796 @default.
• W2085678065 cites W1989506008 @default.
• W2085678065 cites W1999862704 @default.
• W2085678065 cites W2009783162 @default.
• W2085678065 cites W2014350022 @default.
• W2085678065 cites W2016357584 @default.
• W2085678065 cites W2038602542 @default.
• W2085678065 cites W2040783182 @default.
• W2085678065 cites W2045835005 @default.
• W2085678065 cites W2058710679 @default.
• W2085678065 cites W2065009203 @default.
• W2085678065 cites W2066784771 @default.
• W2085678065 cites W2109759840 @default.
• W2085678065 cites W2164116575 @default.
• W2085678065 cites W2412635390 @default.
• W2085678065 cites W4302884661 @default.
• W2085678065 cites W4313324522 @default.
• W2085678065 cites W44963298 @default.
• W2085678065 doi "https://doi.org/10.1016/s0028-3908(97)00140-8" @default.
• W2085678065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9364482" @default.
• W2085678065 hasPublicationYear "1997" @default.
• W2085678065 type Work @default.
• W2085678065 sameAs 2085678065 @default.
• W2085678065 citedByCount "455" @default.
• W2085678065 countsByYear W20856780652012 @default.
• W2085678065 countsByYear W20856780652013 @default.
• W2085678065 countsByYear W20856780652014 @default.
• W2085678065 countsByYear W20856780652015 @default.
• W2085678065 countsByYear W20856780652016 @default.
• W2085678065 countsByYear W20856780652017 @default.
• W2085678065 countsByYear W20856780652018 @default.
• W2085678065 countsByYear W20856780652019 @default.
• W2085678065 countsByYear W20856780652020 @default.
• W2085678065 countsByYear W20856780652021 @default.
• W2085678065 countsByYear W20856780652022 @default.
• W2085678065 countsByYear W20856780652023 @default.
• W2085678065 crossrefType "journal-article" @default.
• W2085678065 hasAuthorship W2085678065A5033548247 @default.
• W2085678065 hasAuthorship W2085678065A5037029834 @default.
• W2085678065 hasAuthorship W2085678065A5042568915 @default.
• W2085678065 hasAuthorship W2085678065A5078972629 @default.
• W2085678065 hasAuthorship W2085678065A5084712627 @default.
• W2085678065 hasAuthorship W2085678065A5087332029 @default.
• W2085678065 hasConcept C104317684 @default.
• W2085678065 hasConcept C105580179 @default.
• W2085678065 hasConcept C142724271 @default.
• W2085678065 hasConcept C153911025 @default.
• W2085678065 hasConcept C170493617 @default.
• W2085678065 hasConcept C196822366 @default.
• W2085678065 hasConcept C203014093 @default.
• W2085678065 hasConcept C204232928 @default.
• W2085678065 hasConcept C2776914184 @default.
• W2085678065 hasConcept C2778837531 @default.
• W2085678065 hasConcept C2779830541 @default.
• W2085678065 hasConcept C2781184567 @default.
• W2085678065 hasConcept C2909073510 @default.
• W2085678065 hasConcept C55493867 @default.
• W2085678065 hasConcept C59822182 @default.
• W2085678065 hasConcept C71924100 @default.
• W2085678065 hasConcept C81439078 @default.
• W2085678065 hasConcept C86803240 @default.
• W2085678065 hasConcept C95444343 @default.
• W2085678065 hasConceptScore W2085678065C104317684 @default.
• W2085678065 hasConceptScore W2085678065C105580179 @default.
• W2085678065 hasConceptScore W2085678065C142724271 @default.
• W2085678065 hasConceptScore W2085678065C153911025 @default.
• W2085678065 hasConceptScore W2085678065C170493617 @default.
• W2085678065 hasConceptScore W2085678065C196822366 @default.
• W2085678065 hasConceptScore W2085678065C203014093 @default.
• W2085678065 hasConceptScore W2085678065C204232928 @default.
• W2085678065 hasConceptScore W2085678065C2776914184 @default.
• W2085678065 hasConceptScore W2085678065C2778837531 @default.
• W2085678065 hasConceptScore W2085678065C2779830541 @default.
• W2085678065 hasConceptScore W2085678065C2781184567 @default.
• W2085678065 hasConceptScore W2085678065C2909073510 @default.
• W2085678065 hasConceptScore W2085678065C55493867 @default.
• W2085678065 hasConceptScore W2085678065C59822182 @default.
• W2085678065 hasConceptScore W2085678065C71924100 @default.
• W2085678065 hasConceptScore W2085678065C81439078 @default.

• next