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• W2085678636 abstract "<i>Objective:</i> Paclitaxel-cisplatin is considered to be a standard therapy for metastatic non-small-cell lung cancer (NSCLC). The aim of this study was to evaluate the activity and toxicity of this combination with vinorelbine or gemcitabine as front-line therapy in brain metastases from NSCLC. <i>Methods:</i> Twenty-six chemotherapy-naive patients with an ECOG performance status of 0–2 were treated with paclitaxel (135 mg/m²) on day 1, cisplatin (120 mg/m²) on day 1, and either vinorelbine (30 mg/m²) on days 1 and 15 or gemcitabine (800 mg/m²) on days 1 and 8. Whole-brain irradiation was offered early in case of progression and later as consolidation treatment. <i>Results:</i> All patients were evaluated for toxicity and 25 for response. An intracranial response rate was observed in 38% of the patients (95% CI: 22–59%). WHO grade 3–4 neutropenia and thrombocytopenia occurred in 31 and 4% of the patients, respectively. There was one treatment-related death. Non-hematological toxicities were mild. After a median follow-up of 46 months, the median overall survival for all patients was 21.4 weeks and the median time to progression was 12.8 weeks. <i>Conclusions:</i> Paclitaxel and cisplatin combined with vinorelbine or gemcitabine as front-line therapy in brain metastases seem to achieve responses similar to those for extracranial disease, suggesting a meaningful role in this setting." @default.
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• W2085678636 date "2002-12-04" @default.
• W2085678636 modified "2023-10-18" @default.
• W2085678636 title "Front-Line Paclitaxel/Cisplatin-Based Chemotherapy in Brain Metastases from Non-Small-Cell Lung Cancer" @default.
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• W2085678636 doi "https://doi.org/10.1159/000066520" @default.
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