Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085682413> ?p ?o ?g. }
- W2085682413 endingPage "1493" @default.
- W2085682413 startingPage "1487" @default.
- W2085682413 abstract "BackgroundFew studies have yet addressed the effects of di(2-ethylhexyl) phthalate (DEHP) in house dust on human nasal mucosa.ObjectivesWe investigated the effects of house dust containing DEHP on nasal mucosa of healthy and house dust mite (HDM)–allergic subjects in a short-term exposure setting.MethodsWe challenged 16 healthy and 16 HDM-allergic subjects for 3 hr with house dust at a concentration of 300 μg/m3 containing either low (0.41 mg/g) or high (2.09 mg/g) levels of DEHP. Exposure to filtered air served as control. After exposure, we measured proteins and performed a DNA microarray analysis.ResultsNasal exposure to house dust with low or high DEHP had no effect on symptom scores. Healthy subjects had almost no response to inhaled dust, but HDM-allergic subjects showed varied responses: DEHPlow house dust increased eosinophil cationic protein, granulocyte-colony–stimulating factor (G-CSF), interleukin (IL)-5, and IL-6, whereas DEHPhigh house dust decreased G-CSF and IL-6. Furthermore, in healthy subjects, DEHP concentration resulted in 10 differentially expressed genes, whereas 16 genes were differentially expressed in HDM-allergic subjects, among them anti-Müllerian hormone, which was significantly up-regulated after exposure to DEHPhigh house dust compared with exposure to DEHPlow house dust, and fibroblast growth factor 9, IL-6, and transforming growth factor-β1, which were down-regulated.ConclusionsShort-term exposure to house dust with high concentrations of DEHP has attenuating effects on human nasal immune response in HDM-allergic subjects, concerning both gene expression and cytokines." @default.
- W2085682413 created "2016-06-24" @default.
- W2085682413 creator A5017656696 @default.
- W2085682413 creator A5026197991 @default.
- W2085682413 creator A5034610056 @default.
- W2085682413 creator A5041291683 @default.
- W2085682413 creator A5061198446 @default.
- W2085682413 creator A5087584591 @default.
- W2085682413 date "2008-11-01" @default.
- W2085682413 modified "2023-10-18" @default.
- W2085682413 title "A Controlled Challenge Study on Di(2-ethylhexyl) Phthalate (DEHP) in House Dust and the Immune Response in Human Nasal Mucosa of Allergic Subjects" @default.
- W2085682413 cites W1577988295 @default.
- W2085682413 cites W1965946273 @default.
- W2085682413 cites W1973018580 @default.
- W2085682413 cites W1975121369 @default.
- W2085682413 cites W1975216365 @default.
- W2085682413 cites W1975899300 @default.
- W2085682413 cites W1976515655 @default.
- W2085682413 cites W1989914657 @default.
- W2085682413 cites W1993344922 @default.
- W2085682413 cites W2002113233 @default.
- W2085682413 cites W2006484223 @default.
- W2085682413 cites W2012927390 @default.
- W2085682413 cites W2014287839 @default.
- W2085682413 cites W2023865075 @default.
- W2085682413 cites W2023873526 @default.
- W2085682413 cites W2026254290 @default.
- W2085682413 cites W2027998702 @default.
- W2085682413 cites W2033833869 @default.
- W2085682413 cites W2041399813 @default.
- W2085682413 cites W2041517137 @default.
- W2085682413 cites W2047043504 @default.
- W2085682413 cites W2049915625 @default.
- W2085682413 cites W2056920219 @default.
- W2085682413 cites W2059073399 @default.
- W2085682413 cites W2064089385 @default.
- W2085682413 cites W2064787790 @default.
- W2085682413 cites W2067341730 @default.
- W2085682413 cites W2071684520 @default.
- W2085682413 cites W2072666254 @default.
- W2085682413 cites W2076376459 @default.
- W2085682413 cites W2078558418 @default.
- W2085682413 cites W2078638321 @default.
- W2085682413 cites W2079419008 @default.
- W2085682413 cites W2081235822 @default.
- W2085682413 cites W2088260016 @default.
- W2085682413 cites W2091724559 @default.
- W2085682413 cites W2095068720 @default.
- W2085682413 cites W2104798396 @default.
- W2085682413 cites W2125018347 @default.
- W2085682413 cites W2129578663 @default.
- W2085682413 cites W2134862220 @default.
- W2085682413 cites W2146831067 @default.
- W2085682413 cites W2148492226 @default.
- W2085682413 cites W2148562253 @default.
- W2085682413 cites W2149438998 @default.
- W2085682413 cites W2154208403 @default.
- W2085682413 cites W2165625418 @default.
- W2085682413 cites W2169341838 @default.
- W2085682413 cites W2171299663 @default.
- W2085682413 cites W2601704071 @default.
- W2085682413 doi "https://doi.org/10.1289/ehp.11474" @default.
- W2085682413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2592268" @default.
- W2085682413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19057701" @default.
- W2085682413 hasPublicationYear "2008" @default.
- W2085682413 type Work @default.
- W2085682413 sameAs 2085682413 @default.
- W2085682413 citedByCount "55" @default.
- W2085682413 countsByYear W20856824132012 @default.
- W2085682413 countsByYear W20856824132013 @default.
- W2085682413 countsByYear W20856824132014 @default.
- W2085682413 countsByYear W20856824132015 @default.
- W2085682413 countsByYear W20856824132016 @default.
- W2085682413 countsByYear W20856824132017 @default.
- W2085682413 countsByYear W20856824132018 @default.
- W2085682413 countsByYear W20856824132019 @default.
- W2085682413 countsByYear W20856824132020 @default.
- W2085682413 countsByYear W20856824132021 @default.
- W2085682413 countsByYear W20856824132022 @default.
- W2085682413 countsByYear W20856824132023 @default.
- W2085682413 crossrefType "journal-article" @default.
- W2085682413 hasAuthorship W2085682413A5017656696 @default.
- W2085682413 hasAuthorship W2085682413A5026197991 @default.
- W2085682413 hasAuthorship W2085682413A5034610056 @default.
- W2085682413 hasAuthorship W2085682413A5041291683 @default.
- W2085682413 hasAuthorship W2085682413A5061198446 @default.
- W2085682413 hasAuthorship W2085682413A5087584591 @default.
- W2085682413 hasBestOaLocation W20856824131 @default.
- W2085682413 hasConcept C178790620 @default.
- W2085682413 hasConcept C185592680 @default.
- W2085682413 hasConcept C203014093 @default.
- W2085682413 hasConcept C207480886 @default.
- W2085682413 hasConcept C2776042228 @default.
- W2085682413 hasConcept C2777037409 @default.
- W2085682413 hasConcept C2778166374 @default.
- W2085682413 hasConcept C2780510475 @default.
- W2085682413 hasConcept C2781005124 @default.
- W2085682413 hasConcept C2909814679 @default.