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• W2085682466 endingPage "377" @default.
• W2085682466 startingPage "366" @default.
• W2085682466 abstract "Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is a key regulator of the activation of transcription factor NF-κB by the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily. Recruitment of TRAF6 to the receptor-associated IRAK1-IRAK4-MyD88 adaptor protein complex induces lysine 63 (K63) autopolyubiquitination of TRAF6, which leads to further recruitment of downstream regulators, such as TAB2/3 and TAK1, and subsequently triggers NF-κB activation. Here, we identified the putative E2 ubiquitin-conjugating (UBC) enzyme UBE2O as a novel negative regulator of TRAF6-dependent NF-κB signaling. We found that UBE2O binds to TRAF6 to inhibit its K63-polyubiquitination, and to prevent the activation of NF-κB by IL-1β and lipopolysaccharides (LPS). We further show that the inhibitory effect of UBE2O is independent of its carboxy-terminal UBC domain. In contrast, we found that UBE2O acts to disrupt the IL-1β-induced association of TRAF6 with MyD88. These results provide novel insight into the regulation of signaling by IL-1R/TLR and TRAF6." @default.
• W2085682466 created "2016-06-24" @default.
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• W2085682466 date "2013-02-05" @default.
• W2085682466 modified "2023-10-12" @default.
• W2085682466 title "UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination" @default.
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• W2085682466 doi "https://doi.org/10.1038/cr.2013.21" @default.
• W2085682466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3587711" @default.
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• W2085682466 hasPublicationYear "2013" @default.
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