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• W2085682801 abstract "The antifungal activity of purpurin (1,2,4-trihydroxy-9,10-anthraquinone), a natural red anthraquinone pigment in madder root (Rubia tinctorum L.), was evaluated by a broth microdilution assay against a total of 24 Candida isolates representing six species. The minimum inhibitory concentration (MIC) range of purpurin was 1.28–5.12 µg/ml. Mechanistic studies using the rhodamine 6G extrusion assay indicated that purpurin inhibited the energy-dependent efflux pumps of the Candida isolates in a dose-dependent manner. Furthermore, purpurin demonstrated a dose-dependent depolarization of mitochondrial membrane potential, one of the biochemical checkpoints regulating cell death in eukaryotic cells, suggesting a possible linkage between purpurin antifungal mechanism and Candida apoptosis." @default.
• W2085682801 created "2016-06-24" @default.
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• W2085682801 date "2010-11-01" @default.
• W2085682801 modified "2023-10-14" @default.
• W2085682801 title "Novel antifungal activity of purpurin against<i>Candida</i>species<i>in vitro</i>" @default.
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• W2085682801 doi "https://doi.org/10.3109/13693781003739351" @default.
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