FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085683835> ?p ?o ?g. }

• W2085683835 endingPage "232" @default.
• W2085683835 startingPage "221" @default.
• W2085683835 abstract "Neuroanatomical, electrophysiological and pharmacological studies have provided indirect evidence indicating that GABAergic neurons play a key role in opiate analgesia mediated by the midbrain periaqueductal gray (PAG) and ventromedial medulla. Although these studies suggest that systemic administration of opiates inhibits GABA release in the PAG, there have been no investigations to date that have directly examined this issue. The present study was thus designed to determine whether systemic morphine injection inhibits GABA release in the PAG of awake, freely moving rats using in vivo microdialysis and subsequent HPLC analysis. Extracellular levels of GABA, glutamate, aspartate, glycine, homocysteic acid and taurine were monitored with the microdialysis technique in either the lateral or medial portion of the ventrocaudal PAG in unanesthetized, unrestrained rats. Amino acid release was induced by infusing veratridine (75 microM, a sodium channel activator) directly through the dialysis probe. The effect of veratridine alone and the effect of veratridine in the presence of systemic morphine on the concentrations of amino acids in the PAG dialysate were determined. There were no significant differences in the basal concentrations of GABA, taurine, aspartate, glutamate, homocysteic acid and glycine between dialysates collected from the medial versus the lateral ventrocaudal PAG. Glycine, taurine and glutamate were present in the highest concentrations in dialysis samples both before and after treatment with veratridine, whereas GABA, homocysteic acid and aspartate were present in the lowest concentrations. Perfusion of veratridine into the ventrocaudal PAG resulted in significant elevation of all amino acids investigated. Except for taurine, no significant difference in veratridine-induced release between the lateral and medial PAG was observed. Tetrodotoxin (TTX) significantly blocked veratridine-induced release of GABA, aspartate, glutamate, glycine and taurine but not homocysteic acid. When rats were injected with morphine (10 mg/kg i.p.), veratridine-induced release of GABA was selectively and significantly decreased in the lateral but not the medial PAG as compared to control rats injected with saline followed by veratridine perfusion. Systemic injection of morphine or saline caused no significant change in the basal concentration of amino acids in PAG dialysate samples. These findings are consistent with the proposed mechanism of action of morphine in the lateral ventrocaudal PAG and offer the first direct evidence that systemic opiates decrease GABA release in this midbrain region." @default.
• W2085683835 created "2016-06-24" @default.
• W2085683835 creator A5040912906 @default.
• W2085683835 creator A5083191280 @default.
• W2085683835 creator A5086017452 @default.
• W2085683835 date "1992-10-01" @default.
• W2085683835 modified "2023-10-10" @default.
• W2085683835 title "Systemic morphine reduces GABA release in the lateral but not the medial portion of the midbrain periaqueductal gray of the rat" @default.
• W2085683835 cites W1575855615 @default.
• W2085683835 cites W1838045633 @default.
• W2085683835 cites W1968642035 @default.
• W2085683835 cites W1975756729 @default.
• W2085683835 cites W1978319366 @default.
• W2085683835 cites W1981020853 @default.
• W2085683835 cites W1982078733 @default.
• W2085683835 cites W1985931825 @default.
• W2085683835 cites W1992137831 @default.
• W2085683835 cites W1992713633 @default.
• W2085683835 cites W1992897355 @default.
• W2085683835 cites W1994561581 @default.
• W2085683835 cites W1994748567 @default.
• W2085683835 cites W1996185004 @default.
• W2085683835 cites W2003028225 @default.
• W2085683835 cites W2005170508 @default.
• W2085683835 cites W2007284096 @default.
• W2085683835 cites W2020388103 @default.
• W2085683835 cites W2023858005 @default.
• W2085683835 cites W2025114609 @default.
• W2085683835 cites W2025267797 @default.
• W2085683835 cites W2036761672 @default.
• W2085683835 cites W2036896908 @default.
• W2085683835 cites W2039558360 @default.
• W2085683835 cites W2040342883 @default.
• W2085683835 cites W2043898558 @default.
• W2085683835 cites W2050608362 @default.
• W2085683835 cites W2050637257 @default.
• W2085683835 cites W2053385743 @default.
• W2085683835 cites W2055608327 @default.
• W2085683835 cites W2055628150 @default.
• W2085683835 cites W2063134225 @default.
• W2085683835 cites W2067292092 @default.
• W2085683835 cites W2068055837 @default.
• W2085683835 cites W2070517002 @default.
• W2085683835 cites W2081678712 @default.
• W2085683835 cites W2084814400 @default.
• W2085683835 cites W2090408408 @default.
• W2085683835 cites W2090730837 @default.
• W2085683835 cites W2091061257 @default.
• W2085683835 cites W2091411661 @default.
• W2085683835 cites W2095326121 @default.
• W2085683835 cites W2100040827 @default.
• W2085683835 cites W2138512124 @default.
• W2085683835 cites W2345915005 @default.
• W2085683835 cites W2398218032 @default.
• W2085683835 cites W2412105915 @default.
• W2085683835 cites W2466680436 @default.
• W2085683835 cites W4253014749 @default.
• W2085683835 doi "https://doi.org/10.1016/0006-8993(92)91129-3" @default.
• W2085683835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1450948" @default.
• W2085683835 hasPublicationYear "1992" @default.
• W2085683835 type Work @default.
• W2085683835 sameAs 2085683835 @default.
• W2085683835 citedByCount "80" @default.
• W2085683835 countsByYear W20856838352012 @default.
• W2085683835 countsByYear W20856838352015 @default.
• W2085683835 countsByYear W20856838352016 @default.
• W2085683835 countsByYear W20856838352018 @default.
• W2085683835 countsByYear W20856838352019 @default.
• W2085683835 countsByYear W20856838352023 @default.
• W2085683835 crossrefType "journal-article" @default.
• W2085683835 hasAuthorship W2085683835A5040912906 @default.
• W2085683835 hasAuthorship W2085683835A5083191280 @default.
• W2085683835 hasAuthorship W2085683835A5086017452 @default.
• W2085683835 hasConcept C126322002 @default.
• W2085683835 hasConcept C134018914 @default.
• W2085683835 hasConcept C170493617 @default.
• W2085683835 hasConcept C178790620 @default.
• W2085683835 hasConcept C185592680 @default.
• W2085683835 hasConcept C202751555 @default.
• W2085683835 hasConcept C2776219046 @default.
• W2085683835 hasConcept C2776980637 @default.
• W2085683835 hasConcept C2776986425 @default.
• W2085683835 hasConcept C2779177108 @default.
• W2085683835 hasConcept C2779701627 @default.
• W2085683835 hasConcept C2781372283 @default.
• W2085683835 hasConcept C28406088 @default.
• W2085683835 hasConcept C50156730 @default.
• W2085683835 hasConcept C50952357 @default.
• W2085683835 hasConcept C515207424 @default.
• W2085683835 hasConcept C537181965 @default.
• W2085683835 hasConcept C55493867 @default.
• W2085683835 hasConcept C61174792 @default.
• W2085683835 hasConcept C71924100 @default.
• W2085683835 hasConcept C86803240 @default.
• W2085683835 hasConcept C98274493 @default.
• W2085683835 hasConceptScore W2085683835C126322002 @default.
• W2085683835 hasConceptScore W2085683835C134018914 @default.
• W2085683835 hasConceptScore W2085683835C170493617 @default.

• next