Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085685008> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2085685008 endingPage "152" @default.
- W2085685008 startingPage "152" @default.
- W2085685008 abstract "There are about 20 identified species in the genus Laggera and only few have been extensively investigated. The study was aimed at evaluation the antimicrobial activity of Laggera mollis and isolation of the bioactive component(s) for new potent antimicrobial agent. Four fractions each from the leaves and stem-root of the plant were sequentially extracted with petroleum ether, chloroform, ethyl acetate and ethanol using soxhlet extraction scheme, while the marcs were decocted for the aqueous extracts. Phytochemical screening of four extract fractions each from the leaves and stem-root of the plant revealed the presence of alkaloids, tannins, flavanoids, saponins, steroids, terpenoids and reducing sugar distributed across the fractions. Disc diffusion method of Antimicrobial Sensitivity Test (ATS) was adopted in testing the bioactivity of the plant extracts against seven bacteria and one fungus. Bioassay-guided isolation from the petroleum ether fraction (LM1-01) of the leaves of the Laggera mollis using column chromatography, led to the isolation of two pure compounds. The results of the antimicrobial activity of the isolated compounds indicted that LM1-1-10 was more potent against Salmonella typhi (11 mm) at 40 μg/disc followed by Streptococcus pyogens (10 mm) at 40 μg/disc and Staphylococcus aureus (10 mm) at 40 μg/disc. The spectra of the activity exhibited by the isolates signified their potency for the development of therapeutic agents against these pathogenic microorganisms.Keywords: Bioassay-guided isolation, antimicrobial activity, Laggera mollis, clinical isolates, extracts." @default.
- W2085685008 created "2016-06-24" @default.
- W2085685008 creator A5042036346 @default.
- W2085685008 creator A5045724751 @default.
- W2085685008 date "2014-01-07" @default.
- W2085685008 modified "2023-10-06" @default.
- W2085685008 title "Screening and Bioassay-guided Isolation of Antimicrobial Components from <i>Laggera mollis</i>" @default.
- W2085685008 cites W1581962345 @default.
- W2085685008 cites W187852222 @default.
- W2085685008 cites W2016750201 @default.
- W2085685008 cites W2021614411 @default.
- W2085685008 cites W2039733013 @default.
- W2085685008 cites W2121281156 @default.
- W2085685008 cites W2163446105 @default.
- W2085685008 cites W2379918939 @default.
- W2085685008 cites W2479663229 @default.
- W2085685008 cites W2984196966 @default.
- W2085685008 cites W857721188 @default.
- W2085685008 doi "https://doi.org/10.4314/bajopas.v6i1.29" @default.
- W2085685008 hasPublicationYear "2014" @default.
- W2085685008 type Work @default.
- W2085685008 sameAs 2085685008 @default.
- W2085685008 citedByCount "1" @default.
- W2085685008 countsByYear W20856850082019 @default.
- W2085685008 crossrefType "journal-article" @default.
- W2085685008 hasAuthorship W2085685008A5042036346 @default.
- W2085685008 hasAuthorship W2085685008A5045724751 @default.
- W2085685008 hasBestOaLocation W20856850081 @default.
- W2085685008 hasConcept C104488531 @default.
- W2085685008 hasConcept C11636898 @default.
- W2085685008 hasConcept C178790620 @default.
- W2085685008 hasConcept C185592680 @default.
- W2085685008 hasConcept C195475562 @default.
- W2085685008 hasConcept C2776148806 @default.
- W2085685008 hasConcept C2779489039 @default.
- W2085685008 hasConcept C2779858419 @default.
- W2085685008 hasConcept C2781144210 @default.
- W2085685008 hasConcept C43617362 @default.
- W2085685008 hasConcept C4725764 @default.
- W2085685008 hasConcept C4937899 @default.
- W2085685008 hasConcept C523546767 @default.
- W2085685008 hasConcept C54355233 @default.
- W2085685008 hasConcept C556039675 @default.
- W2085685008 hasConcept C71924100 @default.
- W2085685008 hasConcept C86803240 @default.
- W2085685008 hasConceptScore W2085685008C104488531 @default.
- W2085685008 hasConceptScore W2085685008C11636898 @default.
- W2085685008 hasConceptScore W2085685008C178790620 @default.
- W2085685008 hasConceptScore W2085685008C185592680 @default.
- W2085685008 hasConceptScore W2085685008C195475562 @default.
- W2085685008 hasConceptScore W2085685008C2776148806 @default.
- W2085685008 hasConceptScore W2085685008C2779489039 @default.
- W2085685008 hasConceptScore W2085685008C2779858419 @default.
- W2085685008 hasConceptScore W2085685008C2781144210 @default.
- W2085685008 hasConceptScore W2085685008C43617362 @default.
- W2085685008 hasConceptScore W2085685008C4725764 @default.
- W2085685008 hasConceptScore W2085685008C4937899 @default.
- W2085685008 hasConceptScore W2085685008C523546767 @default.
- W2085685008 hasConceptScore W2085685008C54355233 @default.
- W2085685008 hasConceptScore W2085685008C556039675 @default.
- W2085685008 hasConceptScore W2085685008C71924100 @default.
- W2085685008 hasConceptScore W2085685008C86803240 @default.
- W2085685008 hasIssue "1" @default.
- W2085685008 hasLocation W20856850081 @default.
- W2085685008 hasOpenAccess W2085685008 @default.
- W2085685008 hasPrimaryLocation W20856850081 @default.
- W2085685008 hasRelatedWork W1598338088 @default.
- W2085685008 hasRelatedWork W2018930346 @default.
- W2085685008 hasRelatedWork W2064347599 @default.
- W2085685008 hasRelatedWork W2353433648 @default.
- W2085685008 hasRelatedWork W2472842275 @default.
- W2085685008 hasRelatedWork W2576246537 @default.
- W2085685008 hasRelatedWork W2888596225 @default.
- W2085685008 hasRelatedWork W3018970247 @default.
- W2085685008 hasRelatedWork W66475781 @default.
- W2085685008 hasRelatedWork W2182098439 @default.
- W2085685008 hasVolume "6" @default.
- W2085685008 isParatext "false" @default.
- W2085685008 isRetracted "false" @default.
- W2085685008 magId "2085685008" @default.
- W2085685008 workType "article" @default.