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- W2085685269 abstract "A recent analysis of hyponatremic patients disclosed that those who were chronically hyponatremic prior to rapid correction subsequently developed central pontine myelinolysis. To test the view that chronicity of hyponatremia is a factor in myelinolysis, we studied a group of rats that were hyponatremic for 1 day and compared it with another group of animals maintained in a hyponatremic state for 3 days prior to the administration of hypertonic saline solution. The 3-day hyponatremic rats developed more numerous and more severe demyelinative lesions than the 1-day rats. The findings support the view that duration of hyponatremia is a factor in myelinolysis and that the electrolyte disturbance of chronically hyponatremic patients should be corrected cautiously and relatively slowly." @default.
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- W2085685269 date "1984-06-01" @default.
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- W2085685269 title "Chronicity of hyponatremia as a factor in experimental myelinolysis" @default.
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- W2085685269 doi "https://doi.org/10.1002/ana.410150606" @default.
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