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- W2085686710 abstract "SummaryThe effects of topically applied 5-fluorouracil (5-FU) ointment on hairy and hairless mice have been studied. Five per cent 5-FU ointment was applied once daily to the dorsal surface of the mice, totalling one, two or seven applications. No changes have occurred in all the hairy mice, while remarkable changes such as erosion or ulcer, followed by skin hypertrophy and pigmentation have occurred after the applications of the drug to hairless mice. In the altered hairless mice, acanthosis, the appearance of active (DOPA positive) melanocytes in the epidermis and dermal cyst wall, and moderate increase in the dermal melanocytes were seen in the marked pigmentation area. Pseudocarcinomatous hyperplasia and a high increase in the dermal melanocytes were seen in the hypertrophic skin.It is suggested that different from the hairy mice skin the hairless mice skin shows abnormal reaction to 5-FU (erosion or ulcer), resulting in epidermal hyperplasia and pigmentation." @default.
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- W2085686710 date "1984-11-01" @default.
- W2085686710 modified "2023-10-18" @default.
- W2085686710 title "Different effects of topically applied 5-fluorouracil on hairy and hairless mice" @default.
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- W2085686710 doi "https://doi.org/10.1111/j.1365-2230.1984.tb00862.x" @default.
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