FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085689489> ?p ?o ?g. }

• W2085689489 endingPage "41" @default.
• W2085689489 startingPage "31" @default.
• W2085689489 abstract "Macrophages rapidly engulf and remove apoptotic cells to limit the release of noxious cellular contents and to restrict autoimmune disease or inflammation. Recent developments reveal an important role in autophagy for clearance of apoptotic corpses. However, the relationship between autophagy and phagocytosis remains unclear. In this study we found that low doses of oridonin, an active diterpenoid, enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells, meanwhile it also induced autophagy in these U937 cells. Moreover, inhibition of extracellular signal-related kinase (ERK), nuclear factor-κB (NF-κB) and caspase-1 significantly suppressed oridonin-induced phagocytosis and autophagy. In addition, oridonin increased the protein levels of p-ERK, NF-κB, caspase-1 and pro IL-1β. Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-κB- and caspase-1-mediated IL-1β release. Beclin-1 (known as autophagic regulator) loss also led to the similar results. Pretreatment with autophagic agonist rapamycin caused opposite results. Autophagy-associated proteins, Beclin-1, LC3 and Atg4B, involved in this phagocytosis process. These results demonstrated that autophagy enhanced oridonin-induced phagocytosis through feedback regulation of ERK, NF-κB- and caspase-1-mediated IL-1β release." @default.
• W2085689489 created "2016-06-24" @default.
• W2085689489 creator A5015928213 @default.
• W2085689489 creator A5016792966 @default.
• W2085689489 creator A5022644338 @default.
• W2085689489 creator A5032005332 @default.
• W2085689489 creator A5045272575 @default.
• W2085689489 creator A5056073435 @default.
• W2085689489 creator A5085085885 @default.
• W2085689489 creator A5091089849 @default.
• W2085689489 date "2012-02-01" @default.
• W2085689489 modified "2023-09-23" @default.
• W2085689489 title "Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cells" @default.
• W2085689489 cites W1499580630 @default.
• W2085689489 cites W1551106278 @default.
• W2085689489 cites W1782545213 @default.
• W2085689489 cites W1804077969 @default.
• W2085689489 cites W1974744480 @default.
• W2085689489 cites W1978751572 @default.
• W2085689489 cites W1979377747 @default.
• W2085689489 cites W1979717090 @default.
• W2085689489 cites W1988327539 @default.
• W2085689489 cites W1992359197 @default.
• W2085689489 cites W1994823455 @default.
• W2085689489 cites W1999477136 @default.
• W2085689489 cites W2017487826 @default.
• W2085689489 cites W2021490026 @default.
• W2085689489 cites W2025234694 @default.
• W2085689489 cites W2025695096 @default.
• W2085689489 cites W2028536701 @default.
• W2085689489 cites W2042260827 @default.
• W2085689489 cites W2054647942 @default.
• W2085689489 cites W2082209726 @default.
• W2085689489 cites W2084470407 @default.
• W2085689489 cites W2088140877 @default.
• W2085689489 cites W2104232394 @default.
• W2085689489 cites W2116505573 @default.
• W2085689489 cites W2117968442 @default.
• W2085689489 cites W2149609961 @default.
• W2085689489 cites W2151892297 @default.
• W2085689489 cites W2157778451 @default.
• W2085689489 cites W2165451118 @default.
• W2085689489 cites W2168212241 @default.
• W2085689489 cites W2324674933 @default.
• W2085689489 cites W4234162206 @default.
• W2085689489 cites W4313175981 @default.
• W2085689489 doi "https://doi.org/10.1016/j.abb.2011.11.019" @default.
• W2085689489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22155150" @default.
• W2085689489 hasPublicationYear "2012" @default.
• W2085689489 type Work @default.
• W2085689489 sameAs 2085689489 @default.
• W2085689489 citedByCount "32" @default.
• W2085689489 countsByYear W20856894892012 @default.
• W2085689489 countsByYear W20856894892013 @default.
• W2085689489 countsByYear W20856894892014 @default.
• W2085689489 countsByYear W20856894892015 @default.
• W2085689489 countsByYear W20856894892016 @default.
• W2085689489 countsByYear W20856894892017 @default.
• W2085689489 countsByYear W20856894892018 @default.
• W2085689489 countsByYear W20856894892019 @default.
• W2085689489 countsByYear W20856894892020 @default.
• W2085689489 countsByYear W20856894892021 @default.
• W2085689489 countsByYear W20856894892022 @default.
• W2085689489 crossrefType "journal-article" @default.
• W2085689489 hasAuthorship W2085689489A5015928213 @default.
• W2085689489 hasAuthorship W2085689489A5016792966 @default.
• W2085689489 hasAuthorship W2085689489A5022644338 @default.
• W2085689489 hasAuthorship W2085689489A5032005332 @default.
• W2085689489 hasAuthorship W2085689489A5045272575 @default.
• W2085689489 hasAuthorship W2085689489A5056073435 @default.
• W2085689489 hasAuthorship W2085689489A5085085885 @default.
• W2085689489 hasAuthorship W2085689489A5091089849 @default.
• W2085689489 hasConcept C160448771 @default.
• W2085689489 hasConcept C184235292 @default.
• W2085689489 hasConcept C185592680 @default.
• W2085689489 hasConcept C190283241 @default.
• W2085689489 hasConcept C203014093 @default.
• W2085689489 hasConcept C203522944 @default.
• W2085689489 hasConcept C2776914184 @default.
• W2085689489 hasConcept C55493867 @default.
• W2085689489 hasConcept C57074206 @default.
• W2085689489 hasConcept C86803240 @default.
• W2085689489 hasConcept C95444343 @default.
• W2085689489 hasConceptScore W2085689489C160448771 @default.
• W2085689489 hasConceptScore W2085689489C184235292 @default.
• W2085689489 hasConceptScore W2085689489C185592680 @default.
• W2085689489 hasConceptScore W2085689489C190283241 @default.
• W2085689489 hasConceptScore W2085689489C203014093 @default.
• W2085689489 hasConceptScore W2085689489C203522944 @default.
• W2085689489 hasConceptScore W2085689489C2776914184 @default.
• W2085689489 hasConceptScore W2085689489C55493867 @default.
• W2085689489 hasConceptScore W2085689489C57074206 @default.
• W2085689489 hasConceptScore W2085689489C86803240 @default.
• W2085689489 hasConceptScore W2085689489C95444343 @default.
• W2085689489 hasIssue "1" @default.
• W2085689489 hasLocation W20856894891 @default.
• W2085689489 hasLocation W20856894892 @default.
• W2085689489 hasOpenAccess W2085689489 @default.

• next