FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085689917> ?p ?o ?g. }

• W2085689917 endingPage "e84241" @default.
• W2085689917 startingPage "e84241" @default.
• W2085689917 abstract "Introduction Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer’s disease (AD). AD is a complex disorder, characterised by several pathological features. The problem with FC studies in patients is that it is not straightforward to focus on a specific aspect of pathology. In the current study, resting state functional magnetic resonance imaging (rsfMRI) is applied in a mouse model of amyloidosis to assess the effects of amyloid pathology on FC in the mouse brain. Methods Nine APP/PS1 transgenic and nine wild-type mice (average age 18.9 months) were imaged on a 7T MRI system. The mice were anesthetized with medetomidine and rsfMRI data were acquired using a gradient echo EPI sequence. The data were analysed using a whole brain seed correlation analysis and interhemispheric FC was evaluated using a pairwise seed analysis. Qualitative histological analyses were performed to assess amyloid pathology, inflammation and synaptic deficits. Results The whole brain seed analysis revealed an overall decrease in FC in the brains of transgenic mice compared to wild-type mice. The results showed that interhemispheric FC was relatively preserved in the motor cortex of the transgenic mice, but decreased in the somatosensory cortex and the hippocampus when compared to the wild-type mice. The pairwise seed analysis confirmed these results. Histological analyses confirmed the presence of amyloid pathology, inflammation and synaptic deficits in the transgenic mice. Conclusions In the current study, rsfMRI demonstrated decreased FC in APP/PS1 transgenic mice compared to wild-type mice in several brain regions. The APP/PS1 transgenic mice had advanced amyloid pathology across the brain, as well as inflammation and synaptic deficits surrounding the amyloid plaques. Future studies should longitudinally evaluate APP/PS1 transgenic mice and correlate the rsfMRI findings to specific stages of amyloid pathology." @default.
• W2085689917 created "2016-06-24" @default.
• W2085689917 creator A5009360745 @default.
• W2085689917 creator A5013264825 @default.
• W2085689917 creator A5022264416 @default.
• W2085689917 creator A5049505943 @default.
• W2085689917 creator A5050076075 @default.
• W2085689917 creator A5063028182 @default.
• W2085689917 creator A5064178107 @default.
• W2085689917 creator A5086150021 @default.
• W2085689917 creator A5088897985 @default.
• W2085689917 date "2013-12-17" @default.
• W2085689917 modified "2023-09-30" @default.
• W2085689917 title "Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis" @default.
• W2085689917 cites W1517716675 @default.
• W2085689917 cites W1600059550 @default.
• W2085689917 cites W1974594322 @default.
• W2085689917 cites W1979631864 @default.
• W2085689917 cites W1997301424 @default.
• W2085689917 cites W2004529887 @default.
• W2085689917 cites W2007572953 @default.
• W2085689917 cites W2009494091 @default.
• W2085689917 cites W2011502145 @default.
• W2085689917 cites W2011913628 @default.
• W2085689917 cites W2029902477 @default.
• W2085689917 cites W2040447574 @default.
• W2085689917 cites W2041736553 @default.
• W2085689917 cites W2044487274 @default.
• W2085689917 cites W2046527675 @default.
• W2085689917 cites W2052652421 @default.
• W2085689917 cites W2065496603 @default.
• W2085689917 cites W2089665913 @default.
• W2085689917 cites W2095491050 @default.
• W2085689917 cites W2096963202 @default.
• W2085689917 cites W2104545183 @default.
• W2085689917 cites W2109862162 @default.
• W2085689917 cites W2134596475 @default.
• W2085689917 cites W2142367912 @default.
• W2085689917 cites W2142943752 @default.
• W2085689917 cites W2156788921 @default.
• W2085689917 cites W2156997013 @default.
• W2085689917 cites W2158592797 @default.
• W2085689917 cites W2170100736 @default.
• W2085689917 cites W2323677956 @default.
• W2085689917 doi "https://doi.org/10.1371/journal.pone.0084241" @default.
• W2085689917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3866274" @default.
• W2085689917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24358348" @default.
• W2085689917 hasPublicationYear "2013" @default.
• W2085689917 type Work @default.
• W2085689917 sameAs 2085689917 @default.
• W2085689917 citedByCount "53" @default.
• W2085689917 countsByYear W20856899172014 @default.
• W2085689917 countsByYear W20856899172015 @default.
• W2085689917 countsByYear W20856899172016 @default.
• W2085689917 countsByYear W20856899172017 @default.
• W2085689917 countsByYear W20856899172018 @default.
• W2085689917 countsByYear W20856899172019 @default.
• W2085689917 countsByYear W20856899172020 @default.
• W2085689917 countsByYear W20856899172021 @default.
• W2085689917 countsByYear W20856899172022 @default.
• W2085689917 countsByYear W20856899172023 @default.
• W2085689917 crossrefType "journal-article" @default.
• W2085689917 hasAuthorship W2085689917A5009360745 @default.
• W2085689917 hasAuthorship W2085689917A5013264825 @default.
• W2085689917 hasAuthorship W2085689917A5022264416 @default.
• W2085689917 hasAuthorship W2085689917A5049505943 @default.
• W2085689917 hasAuthorship W2085689917A5050076075 @default.
• W2085689917 hasAuthorship W2085689917A5063028182 @default.
• W2085689917 hasAuthorship W2085689917A5064178107 @default.
• W2085689917 hasAuthorship W2085689917A5086150021 @default.
• W2085689917 hasAuthorship W2085689917A5088897985 @default.
• W2085689917 hasBestOaLocation W20856899171 @default.
• W2085689917 hasConcept C102230213 @default.
• W2085689917 hasConcept C104317684 @default.
• W2085689917 hasConcept C141035611 @default.
• W2085689917 hasConcept C142724271 @default.
• W2085689917 hasConcept C169760540 @default.
• W2085689917 hasConcept C172497186 @default.
• W2085689917 hasConcept C2777633098 @default.
• W2085689917 hasConcept C2779951007 @default.
• W2085689917 hasConcept C2781161787 @default.
• W2085689917 hasConcept C54355233 @default.
• W2085689917 hasConcept C71924100 @default.
• W2085689917 hasConcept C86803240 @default.
• W2085689917 hasConceptScore W2085689917C102230213 @default.
• W2085689917 hasConceptScore W2085689917C104317684 @default.
• W2085689917 hasConceptScore W2085689917C141035611 @default.
• W2085689917 hasConceptScore W2085689917C142724271 @default.
• W2085689917 hasConceptScore W2085689917C169760540 @default.
• W2085689917 hasConceptScore W2085689917C172497186 @default.
• W2085689917 hasConceptScore W2085689917C2777633098 @default.
• W2085689917 hasConceptScore W2085689917C2779951007 @default.
• W2085689917 hasConceptScore W2085689917C2781161787 @default.
• W2085689917 hasConceptScore W2085689917C54355233 @default.
• W2085689917 hasConceptScore W2085689917C71924100 @default.
• W2085689917 hasConceptScore W2085689917C86803240 @default.
• W2085689917 hasIssue "12" @default.
• W2085689917 hasLocation W20856899171 @default.

• next