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• W2085696007 abstract "<b><i>Background and Objective:</i></b> We aimed to explore to what extent an unselected population of chronic obstructive pulmonary disease (COPD) outpatients would be eligible for inclusion in randomized clinical trials (RCTs). <b><i>Methods:</i></b> Retrospective analysis of the clinical records of outpatient subjects with an ascertained diagnosis of COPD. COPD outpatients were assessed against the following inclusion criteria: 40 < age < 80 years, current or former smokers, forced expiratory volume in the first second (FEV₁) <70% predicted, no long-term oxygen therapy, no other concomitant lung diseases and absence of major extrapulmonary comorbidities. The study consisted of 2 phases; in phase 1, the criteria for inclusion in RCTs on COPD were selected, and in phase 2, the above criteria were applied to an unselected outpatient COPD population. <b><i>Results:</i></b> A total of 578 subjects (83% of the whole group) failed at least one of the inclusion criteria. Lung diseases other than COPD (occurring in 30% of our population, mostly bronchiectasis), long-term oxygen therapy (31%), FEV₁ (19%), age (14%) and extrapulmonary comorbidities such as cognitive impairment (14%), arrhythmias (17%) and congestive heart disease (13%) would have been the most frequent causes for exclusion from RCTs. <b><i>Conclusions:</i></b> In real-life settings, more than 80% of COPD subjects are currently treated by protocols based on results of RCTs for which they would not have been eligible. We encourage a more extensive use of <i>pragmatic</i> trials in COPD to better modulate the application of results of RCTs to patients encountered in daily practice." @default.
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• W2085696007 date "2013-11-20" @default.
• W2085696007 modified "2023-09-25" @default.
• W2085696007 title "What Proportion of Chronic Obstructive Pulmonary Disease Outpatients Is Eligible for Inclusion in Randomized Clinical Trials?" @default.
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• W2085696007 doi "https://doi.org/10.1159/000355082" @default.
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