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- W2085697796 abstract "The mammalian target of rapamycin (mTOR) signalling cascade is involved in the intracellular regulation of protein synthesis, specifically for proteins involved in controlling neuronal morphology and facilitating synaptic plasticity. Research has revealed that the activity of the mTOR cascade is influenced by several extracellular and environmental factors that have been implicated in schizophrenia. Therefore, there is reason to believe that one of the downstream consequences of dysfunction or hypofunction of these factors in schizophrenia is disrupted mTOR signalling and hence impaired protein synthesis. This results in abnormal neurodevelopment and deficient synaptic plasticity, outcomes which could underlie some of the positive, negative and cognitive symptoms of schizophrenia. This review will discuss the functional roles of the mTOR cascade and present evidence in support of a novel mTOR-based hypothesis of the neuropathology of schizophrenia. During neurodevelopment, genetic and epigenetic factors can disrupt mTOR signalling which affects synthesis of proteins essential for correct neuronal growth and network connectivity. This renders the CNS particularly vulnerable to the effects of secondary factors during adolescence which increases the risk of developing schizophrenia in adulthood. This review discusses the functional roles of the mTOR cascade and presents evidence in support of a novel mTOR-based hypothesis of the neuropathology of schizophrenia. Testing this hypothesis will advance our understanding of the aetiology of this illness and reveal novel therapeutic targets." @default.
- W2085697796 created "2016-06-24" @default.
- W2085697796 creator A5023094324 @default.
- W2085697796 creator A5028326172 @default.
- W2085697796 date "2013-12-25" @default.
- W2085697796 modified "2023-10-13" @default.
- W2085697796 title "Is the mTOR-signalling cascade disrupted in Schizophrenia?" @default.
- W2085697796 cites W1517522220 @default.
- W2085697796 cites W155621635 @default.
- W2085697796 cites W1678188980 @default.
- W2085697796 cites W1949632792 @default.
- W2085697796 cites W1964790038 @default.
- W2085697796 cites W1969861119 @default.
- W2085697796 cites W1972346280 @default.
- W2085697796 cites W1975861025 @default.
- W2085697796 cites W1977617725 @default.
- W2085697796 cites W1981097208 @default.
- W2085697796 cites W1983097579 @default.
- W2085697796 cites W1983698019 @default.
- W2085697796 cites W1986301677 @default.
- W2085697796 cites W1987105275 @default.
- W2085697796 cites W1988345639 @default.
- W2085697796 cites W1989697247 @default.
- W2085697796 cites W1993544825 @default.
- W2085697796 cites W1994926162 @default.
- W2085697796 cites W1997402206 @default.
- W2085697796 cites W2002031023 @default.
- W2085697796 cites W2003291414 @default.
- W2085697796 cites W2005996047 @default.
- W2085697796 cites W2012142261 @default.
- W2085697796 cites W2013514700 @default.
- W2085697796 cites W2014604213 @default.
- W2085697796 cites W2017532895 @default.
- W2085697796 cites W2023819606 @default.
- W2085697796 cites W2024583667 @default.
- W2085697796 cites W2026866750 @default.
- W2085697796 cites W2028510921 @default.
- W2085697796 cites W2029037648 @default.
- W2085697796 cites W2035016947 @default.
- W2085697796 cites W2035139662 @default.
- W2085697796 cites W2036950925 @default.
- W2085697796 cites W2037395811 @default.
- W2085697796 cites W2037820216 @default.
- W2085697796 cites W2038874082 @default.
- W2085697796 cites W2041811289 @default.
- W2085697796 cites W2044161108 @default.
- W2085697796 cites W2046645276 @default.
- W2085697796 cites W2047112279 @default.
- W2085697796 cites W2054792363 @default.
- W2085697796 cites W2056994440 @default.
- W2085697796 cites W2057827526 @default.
- W2085697796 cites W2061837661 @default.
- W2085697796 cites W2063563315 @default.
- W2085697796 cites W2063978545 @default.
- W2085697796 cites W2064438779 @default.
- W2085697796 cites W2064794127 @default.
- W2085697796 cites W2065150812 @default.
- W2085697796 cites W2065887259 @default.
- W2085697796 cites W2066046582 @default.
- W2085697796 cites W2066522177 @default.
- W2085697796 cites W2066659565 @default.
- W2085697796 cites W2069930727 @default.
- W2085697796 cites W2070094949 @default.
- W2085697796 cites W2070170260 @default.
- W2085697796 cites W2072514788 @default.
- W2085697796 cites W2076938137 @default.
- W2085697796 cites W2077521744 @default.
- W2085697796 cites W2080946765 @default.
- W2085697796 cites W2083207963 @default.
- W2085697796 cites W2084722042 @default.
- W2085697796 cites W2088661762 @default.
- W2085697796 cites W2095512479 @default.
- W2085697796 cites W2096516060 @default.
- W2085697796 cites W2097095684 @default.
- W2085697796 cites W2100155309 @default.
- W2085697796 cites W2101771026 @default.
- W2085697796 cites W2106267269 @default.
- W2085697796 cites W2108364781 @default.
- W2085697796 cites W2109263914 @default.
- W2085697796 cites W2117028091 @default.
- W2085697796 cites W2117877379 @default.
- W2085697796 cites W2118180039 @default.
- W2085697796 cites W2123996523 @default.
- W2085697796 cites W2126887959 @default.
- W2085697796 cites W2129307474 @default.
- W2085697796 cites W2130039500 @default.
- W2085697796 cites W2130139152 @default.
- W2085697796 cites W2130743873 @default.
- W2085697796 cites W2132662156 @default.
- W2085697796 cites W2135133717 @default.
- W2085697796 cites W2135734842 @default.
- W2085697796 cites W2136381335 @default.
- W2085697796 cites W2142789104 @default.
- W2085697796 cites W2143034003 @default.
- W2085697796 cites W2144059623 @default.
- W2085697796 cites W2147163529 @default.
- W2085697796 cites W2148389554 @default.
- W2085697796 cites W2150473092 @default.