FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085707551> ?p ?o ?g. }

• W2085707551 endingPage "785" @default.
• W2085707551 startingPage "762" @default.
• W2085707551 abstract "Angiogenesis, the formation of new blood vessels from existing vessels is required for many physiological processes and for growth of solid tumors. Initiated by hypoxia, angiogenesis involves binding of angiogenic factors to endothelial cell (EC) receptors and activation of cellular signaling, differentiation, migration, proliferation, interconnection and canalization of ECs, remodeling of the extracellular matrix and stabilization of newly formed vessels. Experimentally, these processes can be studied by several in vitro and in vivo assays focusing on different steps in the process. In vitro, ECs form networks of capillary-like tubes when propagated for three days in coculture with fibroblasts. The tube formation is dependent on vascular endothelial growth factor (VEGF) and omission of VEGF from the culture medium results in the formation of clusters of undifferentiated ECs. Addition of angiogenesis inhibitors to the coculture system disrupts endothelial network formation and influences EC morphology in two distinct ways. Treatment with antibodies to VEGF, soluble VEGF receptor, the VEGF receptor tyrosine kinase inhibitor SU5614, protein tyrosine phosphatase inhibitor (PTPI) IV or levamisole results in the formation of EC clusters of variable size. This cluster morphology is a result of inhibited EC differentiation and levamisole can be inferred to influence and block VEGF signaling. Treatment with platelet factor 4, thrombospondin, rapamycin, suramin, TNP-470, salubrinal, PTPI I, PTPI II, clodronate, NSC87877 or non-steriodal anti-inflammatory drugs (NSAIDs) results in the formation of short cords of ECs, which suggests that these inhibitors have an influence on later steps in the angiogenic process, such as EC proliferation and migration. A humanized antibody to VEGF is one of a few angiogenesis inhibitors used clinically for treatment of cancer. Levamisole is approved for clinical treatment of cancer and is interesting with respect to anti-angiogenic activity in vivo since it inhibits ECs in vitro with a morphology resembling that obtained with antibodies to VEGF." @default.
• W2085707551 created "2016-06-24" @default.
• W2085707551 creator A5014425341 @default.
• W2085707551 creator A5024358039 @default.
• W2085707551 creator A5029228487 @default.
• W2085707551 creator A5085109802 @default.
• W2085707551 creator A5087463104 @default.
• W2085707551 date "2013-06-24" @default.
• W2085707551 modified "2023-10-14" @default.
• W2085707551 title "Influence of Levamisole and Other Angiogenesis Inhibitors on Angiogenesis and Endothelial Cell Morphology in Vitro" @default.
• W2085707551 cites W132680443 @default.
• W2085707551 cites W1486532366 @default.
• W2085707551 cites W1489529330 @default.
• W2085707551 cites W1549631663 @default.
• W2085707551 cites W1568382100 @default.
• W2085707551 cites W1573363574 @default.
• W2085707551 cites W1598952686 @default.
• W2085707551 cites W1600721209 @default.
• W2085707551 cites W1903001176 @default.
• W2085707551 cites W1921143360 @default.
• W2085707551 cites W1946106924 @default.
• W2085707551 cites W1963936132 @default.
• W2085707551 cites W1964661764 @default.
• W2085707551 cites W1969855058 @default.
• W2085707551 cites W1970016838 @default.
• W2085707551 cites W1970637953 @default.
• W2085707551 cites W1972580962 @default.
• W2085707551 cites W1975701262 @default.
• W2085707551 cites W1983557577 @default.
• W2085707551 cites W1983634321 @default.
• W2085707551 cites W1983738772 @default.
• W2085707551 cites W1985510372 @default.
• W2085707551 cites W1988476050 @default.
• W2085707551 cites W1988683816 @default.
• W2085707551 cites W1989802325 @default.
• W2085707551 cites W1990525900 @default.
• W2085707551 cites W1995448769 @default.
• W2085707551 cites W1996910230 @default.
• W2085707551 cites W1998007093 @default.
• W2085707551 cites W2000000541 @default.
• W2085707551 cites W2003991309 @default.
• W2085707551 cites W2004749289 @default.
• W2085707551 cites W2006586449 @default.
• W2085707551 cites W2006901078 @default.
• W2085707551 cites W2010435021 @default.
• W2085707551 cites W2015648732 @default.
• W2085707551 cites W2016569548 @default.
• W2085707551 cites W2020430038 @default.
• W2085707551 cites W2025357672 @default.
• W2085707551 cites W2026351725 @default.
• W2085707551 cites W2030537668 @default.
• W2085707551 cites W2032995169 @default.
• W2085707551 cites W2034646776 @default.
• W2085707551 cites W2035346200 @default.
• W2085707551 cites W2043297474 @default.
• W2085707551 cites W2044030495 @default.
• W2085707551 cites W2047570670 @default.
• W2085707551 cites W2048321002 @default.
• W2085707551 cites W2057147067 @default.
• W2085707551 cites W2059257410 @default.
• W2085707551 cites W2067216473 @default.
• W2085707551 cites W2067992040 @default.
• W2085707551 cites W2068311225 @default.
• W2085707551 cites W2069361214 @default.
• W2085707551 cites W2071015980 @default.
• W2085707551 cites W2072108322 @default.
• W2085707551 cites W2072928113 @default.
• W2085707551 cites W2075780259 @default.
• W2085707551 cites W2077501711 @default.
• W2085707551 cites W2078203861 @default.
• W2085707551 cites W2084587800 @default.
• W2085707551 cites W2086157929 @default.
• W2085707551 cites W2088726343 @default.
• W2085707551 cites W2089039470 @default.
• W2085707551 cites W2091246008 @default.
• W2085707551 cites W2094406330 @default.
• W2085707551 cites W2094919000 @default.
• W2085707551 cites W2097716284 @default.
• W2085707551 cites W2107257265 @default.
• W2085707551 cites W2108592834 @default.
• W2085707551 cites W2109531438 @default.
• W2085707551 cites W2110567472 @default.
• W2085707551 cites W2112431117 @default.
• W2085707551 cites W2113727201 @default.
• W2085707551 cites W2123960080 @default.
• W2085707551 cites W2124156250 @default.
• W2085707551 cites W2132340961 @default.
• W2085707551 cites W2141836567 @default.
• W2085707551 cites W2145255020 @default.
• W2085707551 cites W2153248839 @default.
• W2085707551 cites W2154061285 @default.
• W2085707551 cites W2154450820 @default.
• W2085707551 cites W2157843797 @default.
• W2085707551 cites W2160771533 @default.
• W2085707551 cites W2161049445 @default.
• W2085707551 cites W2161659842 @default.
• W2085707551 cites W2165336459 @default.
• W2085707551 cites W2166227518 @default.

• next