Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085714777> ?p ?o ?g. }
- W2085714777 endingPage "590" @default.
- W2085714777 startingPage "585" @default.
- W2085714777 abstract "In holoendemic Plasmodium falciparum transmission regions, malarial anemia is a leading cause of childhood morbidity and mortality. Identifying biomarkers of malaria disease severity is important for identifying at-risk groups and for improved understanding of the molecular pathways that influence clinical outcomes. We have previously shown that decreased cyclooxygenase (COX)-2-derived prostaglandin E2 (PGE2) levels are associated with enhanced clinical severity in cerebral malaria, malarial anemia, and malaria during pregnancy. Since children with malaria often have increased incidence of additional infections, such as bacteremia and HIV-1, we extend our previous findings by investigating COX-2 and PGE2 in children with falciparum malaria and co-infection with either bacteremia or HIV-1. Plasma bicyclo-PGE2/creatinine levels and peripheral blood COX-2 transcripts were significantly reduced in co-infected children relative to those with malaria mono-infection. Furthermore, suppression of circulating bicyclo-PGE2 was significantly associated with reduced hemoglobin levels in both mono- and co-infected children with malaria, suggesting that bicyclo-PGE2 may represent both a marker and mediator of malaria pathogenesis." @default.
- W2085714777 created "2016-06-24" @default.
- W2085714777 creator A5001399333 @default.
- W2085714777 creator A5025541170 @default.
- W2085714777 creator A5033489385 @default.
- W2085714777 creator A5042063773 @default.
- W2085714777 creator A5044850402 @default.
- W2085714777 creator A5048158747 @default.
- W2085714777 creator A5088287870 @default.
- W2085714777 date "2013-07-01" @default.
- W2085714777 modified "2023-09-24" @default.
- W2085714777 title "Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia" @default.
- W2085714777 cites W1510660421 @default.
- W2085714777 cites W1660693249 @default.
- W2085714777 cites W1771770550 @default.
- W2085714777 cites W1984103620 @default.
- W2085714777 cites W1985722668 @default.
- W2085714777 cites W1992276344 @default.
- W2085714777 cites W1996315201 @default.
- W2085714777 cites W2007052739 @default.
- W2085714777 cites W2008373701 @default.
- W2085714777 cites W2021678877 @default.
- W2085714777 cites W2026264428 @default.
- W2085714777 cites W2034451611 @default.
- W2085714777 cites W2035451205 @default.
- W2085714777 cites W2039908748 @default.
- W2085714777 cites W2042141765 @default.
- W2085714777 cites W2043727594 @default.
- W2085714777 cites W2046059061 @default.
- W2085714777 cites W2048427468 @default.
- W2085714777 cites W2048588145 @default.
- W2085714777 cites W2060287300 @default.
- W2085714777 cites W2062185077 @default.
- W2085714777 cites W2085680573 @default.
- W2085714777 cites W2091826513 @default.
- W2085714777 cites W2097811192 @default.
- W2085714777 cites W2099554849 @default.
- W2085714777 cites W2110553928 @default.
- W2085714777 cites W2111716480 @default.
- W2085714777 cites W2114804812 @default.
- W2085714777 cites W2115977104 @default.
- W2085714777 cites W2125594974 @default.
- W2085714777 cites W2125930156 @default.
- W2085714777 cites W2129247157 @default.
- W2085714777 cites W2130553006 @default.
- W2085714777 cites W2131931494 @default.
- W2085714777 cites W2139437862 @default.
- W2085714777 cites W2153366331 @default.
- W2085714777 cites W2153694545 @default.
- W2085714777 cites W2154916803 @default.
- W2085714777 cites W2159527878 @default.
- W2085714777 cites W2160714033 @default.
- W2085714777 cites W2164903088 @default.
- W2085714777 cites W2263060160 @default.
- W2085714777 cites W2320812424 @default.
- W2085714777 cites W2322213143 @default.
- W2085714777 cites W4294216491 @default.
- W2085714777 doi "https://doi.org/10.1016/j.bbrc.2013.05.089" @default.
- W2085714777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4703399" @default.
- W2085714777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23743193" @default.
- W2085714777 hasPublicationYear "2013" @default.
- W2085714777 type Work @default.
- W2085714777 sameAs 2085714777 @default.
- W2085714777 citedByCount "10" @default.
- W2085714777 countsByYear W20857147772017 @default.
- W2085714777 countsByYear W20857147772018 @default.
- W2085714777 countsByYear W20857147772021 @default.
- W2085714777 countsByYear W20857147772022 @default.
- W2085714777 countsByYear W20857147772023 @default.
- W2085714777 crossrefType "journal-article" @default.
- W2085714777 hasAuthorship W2085714777A5001399333 @default.
- W2085714777 hasAuthorship W2085714777A5025541170 @default.
- W2085714777 hasAuthorship W2085714777A5033489385 @default.
- W2085714777 hasAuthorship W2085714777A5042063773 @default.
- W2085714777 hasAuthorship W2085714777A5044850402 @default.
- W2085714777 hasAuthorship W2085714777A5048158747 @default.
- W2085714777 hasAuthorship W2085714777A5088287870 @default.
- W2085714777 hasBestOaLocation W20857147772 @default.
- W2085714777 hasConcept C126322002 @default.
- W2085714777 hasConcept C203014093 @default.
- W2085714777 hasConcept C2775867548 @default.
- W2085714777 hasConcept C2778048844 @default.
- W2085714777 hasConcept C2778248108 @default.
- W2085714777 hasConcept C2778371730 @default.
- W2085714777 hasConcept C2779443120 @default.
- W2085714777 hasConcept C2780942790 @default.
- W2085714777 hasConcept C2908793570 @default.
- W2085714777 hasConcept C501593827 @default.
- W2085714777 hasConcept C71924100 @default.
- W2085714777 hasConcept C86803240 @default.
- W2085714777 hasConcept C89423630 @default.
- W2085714777 hasConceptScore W2085714777C126322002 @default.
- W2085714777 hasConceptScore W2085714777C203014093 @default.
- W2085714777 hasConceptScore W2085714777C2775867548 @default.
- W2085714777 hasConceptScore W2085714777C2778048844 @default.
- W2085714777 hasConceptScore W2085714777C2778248108 @default.
- W2085714777 hasConceptScore W2085714777C2778371730 @default.
- W2085714777 hasConceptScore W2085714777C2779443120 @default.