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- W2085738251 abstract "Abstract Allergenic extracts of house dust and a bacterial vaccine with no U. S. standard of potency were examined for their capacity to protect mice against respiratory virus infections. A single intravenous injection of house dust extract resulted in the recovery of significantly less of the Sendai strain of parainfluenza virus from the lungs of mice after aerosol challenge than did an injection of saline. Multiple subcutaneous injections of house dust extract protected more mice against an aerosol challenge of Sendai virus than did a single subcutaneous dose. This increased level of protection was not associated with an increased level of circulating interferon. A single intravenous injection of bacterial vaccine did not protect mice against an aerosol challenge with Sendai virus. Mice were not significantly protected against challenge with influenza viruses by either house dust extract or bacterial vaccine. Although both of these types of products have been shown to be capable of inducing interferon in mice, presumably because they contain endotoxin, the induction of interferon may not be the only mechanism for any antiviral protective effect observed." @default.
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- W2085738251 date "1973-01-01" @default.
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- W2085738251 title "Effect of allergenic extracts of house dust and bacterial vaccine on respiratory infections of mice" @default.
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- W2085738251 doi "https://doi.org/10.1016/0091-6749(73)90002-x" @default.
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