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• W2085751188 abstract "It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamine?-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo." @default.
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• W2085751188 date "2011-01-01" @default.
• W2085751188 modified "2023-10-14" @default.
• W2085751188 title "Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine" @default.
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• W2085751188 doi "https://doi.org/10.2298/abs1103597s" @default.
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