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- W2085751271 abstract "By orchestrating the sequential degradation of a large number of cell cycle regulators, the ubiquitin ligase anaphase-promoting complex (APC/C) is essential for proliferation in all eukaryotes. The correct timing of APC/C-dependent substrate degradation, a critical feature of progression through mitosis, was long known to be controlled by mechanisms targeting the core APC/C-machinery. Recent experiments, however, have revealed an important contribution of substrate-specific regulation of the APC/C to achieve accurate cell division. In this perspective, we describe different mechanisms of substrate-specific APC/C-regulation and discuss their importance for cell division." @default.
- W2085751271 created "2016-06-24" @default.
- W2085751271 creator A5016949741 @default.
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- W2085751271 date "2011-01-01" @default.
- W2085751271 modified "2023-10-13" @default.
- W2085751271 title "Substrate-specific regulation of ubiquitination by the anaphase-promoting complex" @default.
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- W2085751271 doi "https://doi.org/10.4161/cc.10.1.14387" @default.
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