FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085752357> ?p ?o ?g. }

• W2085752357 endingPage "21" @default.
• W2085752357 startingPage "11" @default.
• W2085752357 abstract "A knowledge-based three-dimensional model of an anti-insulin antibody, 125, was constructed using the structures of conserved residues found in other known crystallographic immunoglobulins. Molecular modeling and mechanics were done with the 125 amino acid sequences using QUANTA and CHARMm on a Silicon Graphics 4D70GT workstation. A minimal model was made by scaffolding using crystallography coordinates of the antibody HyHEL-5, because it had the highest amino acid sequence homology with 125 (84% light chain, 65% heavy chain). The three hypervariable loop turns that are longer in 125 than in HyHEL-5 (L1, L3, and H3) were modeled separately and incorporated into the HyHEL-5 structure; then other amino acid substitutions were made and torsions optimized. The 125 model maintains all the structural attributes of an antibody and the structures conserved in known antibodies. Although there are many polar amino acids (especially serines) in this site, the overall van der Waals surface shape is determined by positions of aromatic side chains. Based on this model, it is suggested that hydrogen bonding may be key in the interaction between the human insulin A chain loop antigenic epitope and 125." @default.
• W2085752357 created "2016-06-24" @default.
• W2085752357 creator A5015837947 @default.
• W2085752357 creator A5063396453 @default.
• W2085752357 creator A5075645580 @default.
• W2085752357 date "1992-01-01" @default.
• W2085752357 modified "2023-09-25" @default.
• W2085752357 title "Anti-insulin antibody structure and conformation. I. Molecular modeling and mechanics of an insulin antibody" @default.
• W2085752357 cites W1970130408 @default.
• W2085752357 cites W1976232165 @default.
• W2085752357 cites W1982679430 @default.
• W2085752357 cites W2003331005 @default.
• W2085752357 cites W2004360551 @default.
• W2085752357 cites W2009444140 @default.
• W2085752357 cites W2019651515 @default.
• W2085752357 cites W2031417773 @default.
• W2085752357 cites W2037190935 @default.
• W2085752357 cites W2039532499 @default.
• W2085752357 cites W2050199737 @default.
• W2085752357 cites W2059598532 @default.
• W2085752357 cites W2060289095 @default.
• W2085752357 cites W2064811345 @default.
• W2085752357 cites W2065335184 @default.
• W2085752357 cites W2076694118 @default.
• W2085752357 cites W2077170670 @default.
• W2085752357 cites W2077710118 @default.
• W2085752357 cites W2148672056 @default.
• W2085752357 cites W2162166182 @default.
• W2085752357 cites W2165812178 @default.
• W2085752357 cites W67864273 @default.
• W2085752357 doi "https://doi.org/10.1002/bip.360320104" @default.
• W2085752357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1377513" @default.
• W2085752357 hasPublicationYear "1992" @default.
• W2085752357 type Work @default.
• W2085752357 sameAs 2085752357 @default.
• W2085752357 citedByCount "9" @default.
• W2085752357 countsByYear W20857523572022 @default.
• W2085752357 crossrefType "journal-article" @default.
• W2085752357 hasAuthorship W2085752357A5015837947 @default.
• W2085752357 hasAuthorship W2085752357A5063396453 @default.
• W2085752357 hasAuthorship W2085752357A5075645580 @default.
• W2085752357 hasConcept C104317684 @default.
• W2085752357 hasConcept C126766683 @default.
• W2085752357 hasConcept C147597530 @default.
• W2085752357 hasConcept C154945302 @default.
• W2085752357 hasConcept C159654299 @default.
• W2085752357 hasConcept C167625842 @default.
• W2085752357 hasConcept C169627665 @default.
• W2085752357 hasConcept C178790620 @default.
• W2085752357 hasConcept C178910836 @default.
• W2085752357 hasConcept C181199279 @default.
• W2085752357 hasConcept C185592680 @default.
• W2085752357 hasConcept C195616568 @default.
• W2085752357 hasConcept C204921945 @default.
• W2085752357 hasConcept C25057246 @default.
• W2085752357 hasConcept C36394416 @default.
• W2085752357 hasConcept C41008148 @default.
• W2085752357 hasConcept C47701112 @default.
• W2085752357 hasConcept C515207424 @default.
• W2085752357 hasConcept C521977710 @default.
• W2085752357 hasConcept C54355233 @default.
• W2085752357 hasConcept C55493867 @default.
• W2085752357 hasConcept C59593255 @default.
• W2085752357 hasConcept C71240020 @default.
• W2085752357 hasConcept C77660652 @default.
• W2085752357 hasConcept C8010536 @default.
• W2085752357 hasConcept C86803240 @default.
• W2085752357 hasConceptScore W2085752357C104317684 @default.
• W2085752357 hasConceptScore W2085752357C126766683 @default.
• W2085752357 hasConceptScore W2085752357C147597530 @default.
• W2085752357 hasConceptScore W2085752357C154945302 @default.
• W2085752357 hasConceptScore W2085752357C159654299 @default.
• W2085752357 hasConceptScore W2085752357C167625842 @default.
• W2085752357 hasConceptScore W2085752357C169627665 @default.
• W2085752357 hasConceptScore W2085752357C178790620 @default.
• W2085752357 hasConceptScore W2085752357C178910836 @default.
• W2085752357 hasConceptScore W2085752357C181199279 @default.
• W2085752357 hasConceptScore W2085752357C185592680 @default.
• W2085752357 hasConceptScore W2085752357C195616568 @default.
• W2085752357 hasConceptScore W2085752357C204921945 @default.
• W2085752357 hasConceptScore W2085752357C25057246 @default.
• W2085752357 hasConceptScore W2085752357C36394416 @default.
• W2085752357 hasConceptScore W2085752357C41008148 @default.
• W2085752357 hasConceptScore W2085752357C47701112 @default.
• W2085752357 hasConceptScore W2085752357C515207424 @default.
• W2085752357 hasConceptScore W2085752357C521977710 @default.
• W2085752357 hasConceptScore W2085752357C54355233 @default.
• W2085752357 hasConceptScore W2085752357C55493867 @default.
• W2085752357 hasConceptScore W2085752357C59593255 @default.
• W2085752357 hasConceptScore W2085752357C71240020 @default.
• W2085752357 hasConceptScore W2085752357C77660652 @default.
• W2085752357 hasConceptScore W2085752357C8010536 @default.
• W2085752357 hasConceptScore W2085752357C86803240 @default.
• W2085752357 hasIssue "1" @default.
• W2085752357 hasLocation W20857523571 @default.
• W2085752357 hasLocation W20857523572 @default.
• W2085752357 hasOpenAccess W2085752357 @default.
• W2085752357 hasPrimaryLocation W20857523571 @default.

• next