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- W2085752460 abstract "As an initial effort to discern some of the fine features of cholinergic anionic receptors, a study was made on inhibitors of acetylcholinesterase which used inhibitors that are relatively free from conformational variation. The inhibitors used were quaternized 1-azabicyclo (2.2.2)octanes. The bicyclic parent amine was prepared by several conventional procedures. The salts were evaluated as competitive inhibitors of acetylcholinesterase by a titrimetric procedure. The affinity of these compounds for the anionic site of this enzyme was compared to the affinity of a series of related salts subject to conformational variation. These comparisons suggest that there are stereochemical requirements for the anionic site of this cholinergic receptor more specific than heretofore suspected. As an initial effort to discern some of the fine features of cholinergic anionic receptors, a study was made on inhibitors of acetylcholinesterase which used inhibitors that are relatively free from conformational variation. The inhibitors used were quaternized 1-azabicyclo (2.2.2)octanes. The bicyclic parent amine was prepared by several conventional procedures. The salts were evaluated as competitive inhibitors of acetylcholinesterase by a titrimetric procedure. The affinity of these compounds for the anionic site of this enzyme was compared to the affinity of a series of related salts subject to conformational variation. These comparisons suggest that there are stereochemical requirements for the anionic site of this cholinergic receptor more specific than heretofore suspected." @default.
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- W2085752460 date "1965-06-01" @default.
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- W2085752460 title "Cholinergic Anionic Receptors I" @default.
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- W2085752460 doi "https://doi.org/10.1002/jps.2600540614" @default.
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