FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085752644> ?p ?o ?g. }

• W2085752644 endingPage "242" @default.
• W2085752644 startingPage "233" @default.
• W2085752644 abstract "The ability of NK cells to kill a wide range of tumor or virally infected target cells as well as normal allogeneic T cell blasts appears to depend upon the concerted action of multiple triggering NK receptors. In this study, using two specific monoclonal antibodies [(mAb) MA152 and LAP171], we identified a triggering NK receptor expressed at the cell surface as a dimer of approximately 80 kDa (NKp80). NKp80 is expressed by virtually all fresh or activated NK cells and by a minor subset of T cells characterized by the CD56 surface antigen. NKp80 surface expression was also detected in all CD3– and in 6 / 10 CD3+ large granular lymphocyte expansions derived from patients with lymphoproliferative disease of granular lymphocytes. In polyclonal NK cells, mAb-mediated cross-linking of NKp80 resulted in induction of cytolytic activity and Ca2 + mobilization. A marked heterogeneity existed in the magnitude of the cytolytic responses of different NK cell clones to anti-NKp80 mAb. This heterogeneity correlated with the surface density of NKp46 molecules expressed by different NK clones. The mAb-mediated masking of NKp80 led to a partial inhibition of the NK-mediated lysis of appropriate allogeneic phytohemagglutinin-induced T cell blasts, while it had no effect on the lysis of different tumor target cells, including T cell leukemia cells. These data suggest that NKp80 recognizes a ligand on normal T cells that may be down-regulated during tumor transformation. Molecular cloning of the cDNA coding for NKp80 revealed a type II transmembrane molecule of 231 amino acids identical to the putative protein encoded by a recently identified cDNA termed KLRF1." @default.
• W2085752644 created "2016-06-24" @default.
• W2085752644 creator A5006485743 @default.
• W2085752644 creator A5047066070 @default.
• W2085752644 creator A5048640766 @default.
• W2085752644 creator A5066814162 @default.
• W2085752644 creator A5068187248 @default.
• W2085752644 creator A5071490003 @default.
• W2085752644 creator A5071505441 @default.
• W2085752644 creator A5087722204 @default.
• W2085752644 creator A5089302430 @default.
• W2085752644 date "2001-01-01" @default.
• W2085752644 modified "2023-10-18" @default.
• W2085752644 title "Identification of NKp80, a novel triggering molecule expressed by human NK cells" @default.
• W2085752644 cites W106878149 @default.
• W2085752644 cites W1556867369 @default.
• W2085752644 cites W1791206282 @default.
• W2085752644 cites W1964653209 @default.
• W2085752644 cites W1983320974 @default.
• W2085752644 cites W1990279113 @default.
• W2085752644 cites W1992557186 @default.
• W2085752644 cites W2003676228 @default.
• W2085752644 cites W2005765588 @default.
• W2085752644 cites W2014208459 @default.
• W2085752644 cites W2014492625 @default.
• W2085752644 cites W2017976428 @default.
• W2085752644 cites W2023370541 @default.
• W2085752644 cites W2027315624 @default.
• W2085752644 cites W2030546554 @default.
• W2085752644 cites W2040896021 @default.
• W2085752644 cites W2050343039 @default.
• W2085752644 cites W2051179931 @default.
• W2085752644 cites W2058522060 @default.
• W2085752644 cites W2059688685 @default.
• W2085752644 cites W2061672021 @default.
• W2085752644 cites W2067759988 @default.
• W2085752644 cites W2068923616 @default.
• W2085752644 cites W2080386447 @default.
• W2085752644 cites W2094114783 @default.
• W2085752644 cites W2108959182 @default.
• W2085752644 cites W2133109711 @default.
• W2085752644 cites W2133184513 @default.
• W2085752644 cites W2140763432 @default.
• W2085752644 cites W2154518608 @default.
• W2085752644 cites W2160520392 @default.
• W2085752644 cites W2160579328 @default.
• W2085752644 cites W2170069789 @default.
• W2085752644 cites W2170419443 @default.
• W2085752644 cites W2172005924 @default.
• W2085752644 cites W2172180689 @default.
• W2085752644 cites W2301898163 @default.
• W2085752644 cites W250756067 @default.
• W2085752644 doi "https://doi.org/10.1002/1521-4141(200101)31:1<233::aid-immu233>3.0.co;2-4" @default.
• W2085752644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11265639" @default.
• W2085752644 hasPublicationYear "2001" @default.
• W2085752644 type Work @default.
• W2085752644 sameAs 2085752644 @default.
• W2085752644 citedByCount "190" @default.
• W2085752644 countsByYear W20857526442012 @default.
• W2085752644 countsByYear W20857526442013 @default.
• W2085752644 countsByYear W20857526442014 @default.
• W2085752644 countsByYear W20857526442015 @default.
• W2085752644 countsByYear W20857526442016 @default.
• W2085752644 countsByYear W20857526442017 @default.
• W2085752644 countsByYear W20857526442018 @default.
• W2085752644 countsByYear W20857526442019 @default.
• W2085752644 countsByYear W20857526442020 @default.
• W2085752644 countsByYear W20857526442021 @default.
• W2085752644 countsByYear W20857526442022 @default.
• W2085752644 countsByYear W20857526442023 @default.
• W2085752644 crossrefType "journal-article" @default.
• W2085752644 hasAuthorship W2085752644A5006485743 @default.
• W2085752644 hasAuthorship W2085752644A5047066070 @default.
• W2085752644 hasAuthorship W2085752644A5048640766 @default.
• W2085752644 hasAuthorship W2085752644A5066814162 @default.
• W2085752644 hasAuthorship W2085752644A5068187248 @default.
• W2085752644 hasAuthorship W2085752644A5071490003 @default.
• W2085752644 hasAuthorship W2085752644A5071505441 @default.
• W2085752644 hasAuthorship W2085752644A5087722204 @default.
• W2085752644 hasAuthorship W2085752644A5089302430 @default.
• W2085752644 hasBestOaLocation W20857526441 @default.
• W2085752644 hasConcept C104317684 @default.
• W2085752644 hasConcept C114684123 @default.
• W2085752644 hasConcept C129374314 @default.
• W2085752644 hasConcept C141440757 @default.
• W2085752644 hasConcept C147483822 @default.
• W2085752644 hasConcept C149532602 @default.
• W2085752644 hasConcept C153911025 @default.
• W2085752644 hasConcept C154317977 @default.
• W2085752644 hasConcept C159654299 @default.
• W2085752644 hasConcept C167672396 @default.
• W2085752644 hasConcept C170493617 @default.
• W2085752644 hasConcept C202751555 @default.
• W2085752644 hasConcept C203014093 @default.
• W2085752644 hasConcept C2778102761 @default.
• W2085752644 hasConcept C542903549 @default.
• W2085752644 hasConcept C55493867 @default.
• W2085752644 hasConcept C67662055 @default.

• next