FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085752802> ?p ?o ?g. }

• W2085752802 endingPage "412" @default.
• W2085752802 startingPage "407" @default.
• W2085752802 abstract "The botulinum neurotoxins (BoNTs) produced by different strains of the bacterium Clostridium botulinum are responsible for the disease botulism and include a group of immunologically distinct serotypes (A, B, E, and F) that are considered to be the most lethal natural proteins known for humans. Two BoNT serotypes, C and D, while rarely associated with human infection, are responsible for deadly botulism outbreaks afflicting animals. Also associated with animal infections is the BoNT C-D mosaic protein (BoNT/CD), a BoNT subtype that is essentially a hybrid of the BoNT/C (∼two-third) and BoNT/D (∼one-third) serotypes. While the amino acid sequence of the heavy chain receptor binding (HCR) domain of BoNT/CD (BoNT/CD-HCR) is very similar to the corresponding amino acid sequence of BoNT/D, BoNT/CD-HCR binds synaptosome membranes better than BoNT/D-HCR. To obtain structural insights for the different membrane binding properties, the crystal structure of BoNT/CD-HCR (S867-E1280) was determined at 1.56 Å resolution and compared to previously reported structures for BoNT/D-HCR. Overall, the BoNT/CD-HCR structure is similar to the two sub-domain organization observed for other BoNT HCRs: an N-terminal jellyroll barrel motif and a C-terminal β-trefoil fold. Comparison of the structure of BoNT/CD-HCR with BoNT/D-HCR indicates that K1118 has a similar structural role as the equivalent residue, E1114, in BoNT/D-HCR, while K1136 has a structurally different role than the equivalent residue, G1132, in BoNT/D-HCR. Lysine-1118 forms a salt bridge with E1247 and may enhance membrane interactions by stabilizing the putative membrane binding loop (K1240-N1248). Lysine-1136 is observed on the surface of the protein. A sulfate ion bound to K1136 may mimic a natural interaction with the negatively changed phospholipid membrane surface. Liposome-binding experiments demonstrate that BoNT/CD-HCR binds phosphatidylethanolamine liposomes more tightly than BoNT/D-HCR." @default.
• W2085752802 created "2016-06-24" @default.
• W2085752802 creator A5005637553 @default.
• W2085752802 creator A5006724040 @default.
• W2085752802 creator A5030937712 @default.
• W2085752802 creator A5033465444 @default.
• W2085752802 creator A5078223433 @default.
• W2085752802 date "2011-01-01" @default.
• W2085752802 modified "2023-09-25" @default.
• W2085752802 title "Crystal structure of the receptor binding domain of the botulinum C–D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions" @default.
• W2085752802 cites W1539796472 @default.
• W2085752802 cites W1975357978 @default.
• W2085752802 cites W1978809713 @default.
• W2085752802 cites W2001641653 @default.
• W2085752802 cites W2009698093 @default.
• W2085752802 cites W2018321735 @default.
• W2085752802 cites W2025406853 @default.
• W2085752802 cites W2031154197 @default.
• W2085752802 cites W2033500343 @default.
• W2085752802 cites W2035545621 @default.
• W2085752802 cites W2045544140 @default.
• W2085752802 cites W2048353948 @default.
• W2085752802 cites W2048927738 @default.
• W2085752802 cites W2053492423 @default.
• W2085752802 cites W2056155828 @default.
• W2085752802 cites W2075826540 @default.
• W2085752802 cites W2093558788 @default.
• W2085752802 cites W2121293808 @default.
• W2085752802 cites W2144081223 @default.
• W2085752802 cites W2154714625 @default.
• W2085752802 cites W2159602862 @default.
• W2085752802 cites W2160463128 @default.
• W2085752802 cites W2161282086 @default.
• W2085752802 cites W2175990574 @default.
• W2085752802 cites W2180229411 @default.
• W2085752802 cites W65783484 @default.
• W2085752802 cites W69916898 @default.
• W2085752802 doi "https://doi.org/10.1016/j.bbrc.2010.11.134" @default.
• W2085752802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3019264" @default.
• W2085752802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21130733" @default.
• W2085752802 hasPublicationYear "2011" @default.
• W2085752802 type Work @default.
• W2085752802 sameAs 2085752802 @default.
• W2085752802 citedByCount "20" @default.
• W2085752802 countsByYear W20857528022012 @default.
• W2085752802 countsByYear W20857528022013 @default.
• W2085752802 countsByYear W20857528022014 @default.
• W2085752802 countsByYear W20857528022015 @default.
• W2085752802 countsByYear W20857528022016 @default.
• W2085752802 countsByYear W20857528022018 @default.
• W2085752802 countsByYear W20857528022019 @default.
• W2085752802 countsByYear W20857528022022 @default.
• W2085752802 countsByYear W20857528022023 @default.
• W2085752802 crossrefType "journal-article" @default.
• W2085752802 hasAuthorship W2085752802A5005637553 @default.
• W2085752802 hasAuthorship W2085752802A5006724040 @default.
• W2085752802 hasAuthorship W2085752802A5030937712 @default.
• W2085752802 hasAuthorship W2085752802A5033465444 @default.
• W2085752802 hasAuthorship W2085752802A5078223433 @default.
• W2085752802 hasBestOaLocation W20857528022 @default.
• W2085752802 hasConcept C10389963 @default.
• W2085752802 hasConcept C104317684 @default.
• W2085752802 hasConcept C159047783 @default.
• W2085752802 hasConcept C167625842 @default.
• W2085752802 hasConcept C2777010668 @default.
• W2085752802 hasConcept C2777367657 @default.
• W2085752802 hasConcept C2779186577 @default.
• W2085752802 hasConcept C2994342964 @default.
• W2085752802 hasConcept C55493867 @default.
• W2085752802 hasConcept C86803240 @default.
• W2085752802 hasConcept C89423630 @default.
• W2085752802 hasConceptScore W2085752802C10389963 @default.
• W2085752802 hasConceptScore W2085752802C104317684 @default.
• W2085752802 hasConceptScore W2085752802C159047783 @default.
• W2085752802 hasConceptScore W2085752802C167625842 @default.
• W2085752802 hasConceptScore W2085752802C2777010668 @default.
• W2085752802 hasConceptScore W2085752802C2777367657 @default.
• W2085752802 hasConceptScore W2085752802C2779186577 @default.
• W2085752802 hasConceptScore W2085752802C2994342964 @default.
• W2085752802 hasConceptScore W2085752802C55493867 @default.
• W2085752802 hasConceptScore W2085752802C86803240 @default.
• W2085752802 hasConceptScore W2085752802C89423630 @default.
• W2085752802 hasFunder F4320337355 @default.
• W2085752802 hasFunder F4320337375 @default.
• W2085752802 hasIssue "1" @default.
• W2085752802 hasLocation W20857528021 @default.
• W2085752802 hasLocation W20857528022 @default.
• W2085752802 hasLocation W20857528023 @default.
• W2085752802 hasLocation W20857528024 @default.
• W2085752802 hasOpenAccess W2085752802 @default.
• W2085752802 hasPrimaryLocation W20857528021 @default.
• W2085752802 hasRelatedWork W159636843 @default.
• W2085752802 hasRelatedWork W2045206573 @default.
• W2085752802 hasRelatedWork W2102858266 @default.
• W2085752802 hasRelatedWork W2225433666 @default.
• W2085752802 hasRelatedWork W2393693149 @default.
• W2085752802 hasRelatedWork W2553165592 @default.
• W2085752802 hasRelatedWork W2602919397 @default.

• next