FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085753368> ?p ?o ?g. }

• W2085753368 endingPage "1018" @default.
• W2085753368 startingPage "1010" @default.
• W2085753368 abstract "In the treatment of acute ischemic stroke most of the clinical trials have failed, contrasting with promising results in the preclinical stages. This continuing discrepancy suggests some misconceptions in the understanding of acute ischemic stroke. One possible method for identifying the shortcomings of present-day approaches is to integrate all the available knowledge into a single mathematical model and to subject that model to challenges via simulations with available experimental data. As a first stage, then, the authors developed a simplified model, defining the structure and the different parameters that represent the phenomena that occur during the hyperacute phase of ischemic stroke. First, the different critical points of the evolution of ischemic stroke, based on the available evidence on the pathophysiology of stroke, were identified. Those key steps were then related to the quantitative data obtained by magnetic resonance imaging and positron emission tomography scan. These two techniques allow the measurement of diverse key markers of cerebral metabolism: cerebral blood flow (CBF), oxygen extraction factor, cerebral metabolism rate of oxygen, and the apparent diffusion coefficient of water, among others. Those markers were organized together through mathematical equations, and changed over time in order to describe the evolution of an acute ischemic stroke. At each time during the evolution of stroke those parameters are summarized in a parameter called survival delay. This parameter made possible the definition of three different states for tissues—functional, infarcted, salvageable—as end point. Once the model was designed, simulations were performed to explore its internal validity. Simulation results were consistent with the reality of acute ischemic stroke and did not reveal any major drawbacks in the use of the model. The more rapid the decrease in CBF, the larger is the final infarcted area. The model also allowed for the characterization of two types of tissue in the penumbra: tissues with an initial metabolic impairment and tissues altered owing to the closeness of the ischemic area. The results of this experiment were consistent with what is known of acute ischemic stroke. The model integrated different markers of acute ischemic stroke into a single entity in order to mimic acute ischemic stroke, and has been shown to have a reasonable degree of internal validity." @default.
• W2085753368 created "2016-06-24" @default.
• W2085753368 creator A5016638672 @default.
• W2085753368 creator A5023543619 @default.
• W2085753368 creator A5039037904 @default.
• W2085753368 creator A5048784388 @default.
• W2085753368 creator A5059713827 @default.
• W2085753368 creator A5085600077 @default.
• W2085753368 date "2002-08-01" @default.
• W2085753368 modified "2023-10-16" @default.
• W2085753368 title "Physiologically Based Model of Acute Ischemic Stroke" @default.
• W2085753368 cites W1965655136 @default.
• W2085753368 cites W1966478127 @default.
• W2085753368 cites W1969295152 @default.
• W2085753368 cites W1997244597 @default.
• W2085753368 cites W1997492755 @default.
• W2085753368 cites W2006905163 @default.
• W2085753368 cites W2009049939 @default.
• W2085753368 cites W2035023461 @default.
• W2085753368 cites W2037166104 @default.
• W2085753368 cites W2043007725 @default.
• W2085753368 cites W2046708241 @default.
• W2085753368 cites W2064103390 @default.
• W2085753368 cites W2068288937 @default.
• W2085753368 cites W2071568823 @default.
• W2085753368 cites W2072308062 @default.
• W2085753368 cites W2072926617 @default.
• W2085753368 cites W2083853194 @default.
• W2085753368 cites W2093421851 @default.
• W2085753368 cites W2093655102 @default.
• W2085753368 cites W2108578526 @default.
• W2085753368 cites W2121715561 @default.
• W2085753368 cites W2123351961 @default.
• W2085753368 cites W2123894485 @default.
• W2085753368 cites W2133983274 @default.
• W2085753368 cites W2138394070 @default.
• W2085753368 cites W2138566597 @default.
• W2085753368 cites W2149591826 @default.
• W2085753368 cites W2152580513 @default.
• W2085753368 cites W2155571966 @default.
• W2085753368 cites W2158009878 @default.
• W2085753368 cites W2169079203 @default.
• W2085753368 cites W2323818720 @default.
• W2085753368 doi "https://doi.org/10.1097/00004647-200208000-00013" @default.
• W2085753368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12172387" @default.
• W2085753368 hasPublicationYear "2002" @default.
• W2085753368 type Work @default.
• W2085753368 sameAs 2085753368 @default.
• W2085753368 citedByCount "23" @default.
• W2085753368 countsByYear W20857533682012 @default.
• W2085753368 countsByYear W20857533682013 @default.
• W2085753368 countsByYear W20857533682014 @default.
• W2085753368 countsByYear W20857533682015 @default.
• W2085753368 countsByYear W20857533682016 @default.
• W2085753368 countsByYear W20857533682019 @default.
• W2085753368 countsByYear W20857533682020 @default.
• W2085753368 countsByYear W20857533682022 @default.
• W2085753368 crossrefType "journal-article" @default.
• W2085753368 hasAuthorship W2085753368A5016638672 @default.
• W2085753368 hasAuthorship W2085753368A5023543619 @default.
• W2085753368 hasAuthorship W2085753368A5039037904 @default.
• W2085753368 hasAuthorship W2085753368A5048784388 @default.
• W2085753368 hasAuthorship W2085753368A5059713827 @default.
• W2085753368 hasAuthorship W2085753368A5085600077 @default.
• W2085753368 hasBestOaLocation W20857533681 @default.
• W2085753368 hasConcept C121332964 @default.
• W2085753368 hasConcept C126838900 @default.
• W2085753368 hasConcept C143409427 @default.
• W2085753368 hasConcept C146357865 @default.
• W2085753368 hasConcept C151730666 @default.
• W2085753368 hasConcept C15744967 @default.
• W2085753368 hasConcept C157767197 @default.
• W2085753368 hasConcept C164705383 @default.
• W2085753368 hasConcept C169760540 @default.
• W2085753368 hasConcept C177713679 @default.
• W2085753368 hasConcept C2775842073 @default.
• W2085753368 hasConcept C2780645631 @default.
• W2085753368 hasConcept C3020199598 @default.
• W2085753368 hasConcept C541997718 @default.
• W2085753368 hasConcept C71924100 @default.
• W2085753368 hasConcept C86803240 @default.
• W2085753368 hasConcept C97355855 @default.
• W2085753368 hasConceptScore W2085753368C121332964 @default.
• W2085753368 hasConceptScore W2085753368C126838900 @default.
• W2085753368 hasConceptScore W2085753368C143409427 @default.
• W2085753368 hasConceptScore W2085753368C146357865 @default.
• W2085753368 hasConceptScore W2085753368C151730666 @default.
• W2085753368 hasConceptScore W2085753368C15744967 @default.
• W2085753368 hasConceptScore W2085753368C157767197 @default.
• W2085753368 hasConceptScore W2085753368C164705383 @default.
• W2085753368 hasConceptScore W2085753368C169760540 @default.
• W2085753368 hasConceptScore W2085753368C177713679 @default.
• W2085753368 hasConceptScore W2085753368C2775842073 @default.
• W2085753368 hasConceptScore W2085753368C2780645631 @default.
• W2085753368 hasConceptScore W2085753368C3020199598 @default.
• W2085753368 hasConceptScore W2085753368C541997718 @default.
• W2085753368 hasConceptScore W2085753368C71924100 @default.
• W2085753368 hasConceptScore W2085753368C86803240 @default.

• next