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• W2085753491 endingPage "491" @default.
• W2085753491 startingPage "486" @default.
• W2085753491 abstract "Reprogramming a nucleus by transferring it to oocyte cytoplasm triggers epigenetic changes that eventually lead to the restoration of a totipotent state and the birth of a viable animal. A simplified way of studying this complex process is to study cell hybrids. These studies suggest that the pluripotent character of one nucleus is dominant over that of the other nucleus. The development of nuclear transfer embryos shows that there are several restriction points and that the extra-embryonic lineages may be the primary source of death. Successful reprogramming depends on the balance between epigenetic modifications and the regulative properties of development." @default.
• W2085753491 created "2016-06-24" @default.
• W2085753491 creator A5011273112 @default.
• W2085753491 creator A5086585447 @default.
• W2085753491 date "2003-10-01" @default.
• W2085753491 modified "2023-09-23" @default.
• W2085753491 title "Reprogramming in nuclear transfer" @default.
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• W2085753491 doi "https://doi.org/10.1016/j.gde.2003.08.007" @default.
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