FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085754534> ?p ?o ?g. }

• W2085754534 endingPage "1356" @default.
• W2085754534 startingPage "1350" @default.
• W2085754534 abstract "The intestinal absorption of two ACE inhibitors was studied to determine the potential for colonic delivery of small peptides. In addition, studies were also performed to assess intestinal tissue uptake and evaluate a canine intestinal-access-port model as techniques for screening absorption. To evaluate the impact of differences in the contributions of passive permeation and carrier-mediated peptide transport onin vitro uptake and in vivo absorption, an esterified prodrug, benazepril, and a free diacid non-prodrug, CGS 16617, were selected for study. Potential colonic absorption enhancement utilizing coadministration of Intralipid was also investigated. Studies in rat everted intestinal rings verified that jejunal benazepril uptake included a carrier-mediated component while that of the diacid did not. Uptake of both drugs was purely passive in colonic rings. Equilibrium uptake and uptake rate of the more lipophilic prodrug was 2-fold greater than the diacid. Benazepril and CGS 16617 jejunal uptake rate at 0.01 mM was 3.5 and 2.5 times higher, respectively, than from colonic rings. Following jejunal administration in dogs, maximum benazepril plasma levels (Cmax) and area under the plasma level versus time curve (AUC) were 5.5 and 3.0 times higher, respectively, than following colonic administration. Maximum benazepril plasma levels following colonic administration in dogs was 2-fold greater than for CGS 16617, consistent with in vitro results. Colonic coadministration of the poorly-absorbed CGS 16617 with 2 mL of Intralipid (within dietary range for fecal fat content) enhanced Cmax and AUC 2.5- and 3.5-fold, respectively, in the dog and AUC 1.5-fold in the rat. Morphological and biochemical studies showed that Intralipid did not damage rat jejunal or colonic epithelium in situ." @default.
• W2085754534 created "2016-06-24" @default.
• W2085754534 creator A5053512160 @default.
• W2085754534 creator A5062729861 @default.
• W2085754534 creator A5076946026 @default.
• W2085754534 creator A5077342644 @default.
• W2085754534 creator A5085454422 @default.
• W2085754534 date "1994-09-01" @default.
• W2085754534 modified "2023-10-08" @default.
• W2085754534 title "Absorption of Ace Inhibitors from Small Intestine and Colon" @default.
• W2085754534 cites W105515656 @default.
• W2085754534 cites W1132977027 @default.
• W2085754534 cites W1499839181 @default.
• W2085754534 cites W1502978788 @default.
• W2085754534 cites W1590715777 @default.
• W2085754534 cites W1601603974 @default.
• W2085754534 cites W1990168476 @default.
• W2085754534 cites W2000272041 @default.
• W2085754534 cites W2018730761 @default.
• W2085754534 cites W2051276018 @default.
• W2085754534 cites W2062221416 @default.
• W2085754534 cites W2072907496 @default.
• W2085754534 cites W2074202193 @default.
• W2085754534 cites W2091243547 @default.
• W2085754534 cites W2125147106 @default.
• W2085754534 cites W2158605718 @default.
• W2085754534 cites W251297179 @default.
• W2085754534 cites W256510981 @default.
• W2085754534 cites W4232497266 @default.
• W2085754534 cites W4301464663 @default.
• W2085754534 doi "https://doi.org/10.1002/jps.2600830929" @default.
• W2085754534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7830254" @default.
• W2085754534 hasPublicationYear "1994" @default.
• W2085754534 type Work @default.
• W2085754534 sameAs 2085754534 @default.
• W2085754534 citedByCount "48" @default.
• W2085754534 countsByYear W20857545342012 @default.
• W2085754534 countsByYear W20857545342013 @default.
• W2085754534 countsByYear W20857545342014 @default.
• W2085754534 countsByYear W20857545342015 @default.
• W2085754534 countsByYear W20857545342016 @default.
• W2085754534 countsByYear W20857545342021 @default.
• W2085754534 crossrefType "journal-article" @default.
• W2085754534 hasAuthorship W2085754534A5053512160 @default.
• W2085754534 hasAuthorship W2085754534A5062729861 @default.
• W2085754534 hasAuthorship W2085754534A5076946026 @default.
• W2085754534 hasAuthorship W2085754534A5077342644 @default.
• W2085754534 hasAuthorship W2085754534A5085454422 @default.
• W2085754534 hasBestOaLocation W20857545341 @default.
• W2085754534 hasConcept C108215921 @default.
• W2085754534 hasConcept C112705442 @default.
• W2085754534 hasConcept C125287762 @default.
• W2085754534 hasConcept C126322002 @default.
• W2085754534 hasConcept C150903083 @default.
• W2085754534 hasConcept C159985019 @default.
• W2085754534 hasConcept C185592680 @default.
• W2085754534 hasConcept C192562407 @default.
• W2085754534 hasConcept C207001950 @default.
• W2085754534 hasConcept C22979827 @default.
• W2085754534 hasConcept C2776366702 @default.
• W2085754534 hasConcept C2777056448 @default.
• W2085754534 hasConcept C2777363265 @default.
• W2085754534 hasConcept C55493867 @default.
• W2085754534 hasConcept C71924100 @default.
• W2085754534 hasConcept C84393581 @default.
• W2085754534 hasConcept C86803240 @default.
• W2085754534 hasConcept C98274493 @default.
• W2085754534 hasConceptScore W2085754534C108215921 @default.
• W2085754534 hasConceptScore W2085754534C112705442 @default.
• W2085754534 hasConceptScore W2085754534C125287762 @default.
• W2085754534 hasConceptScore W2085754534C126322002 @default.
• W2085754534 hasConceptScore W2085754534C150903083 @default.
• W2085754534 hasConceptScore W2085754534C159985019 @default.
• W2085754534 hasConceptScore W2085754534C185592680 @default.
• W2085754534 hasConceptScore W2085754534C192562407 @default.
• W2085754534 hasConceptScore W2085754534C207001950 @default.
• W2085754534 hasConceptScore W2085754534C22979827 @default.
• W2085754534 hasConceptScore W2085754534C2776366702 @default.
• W2085754534 hasConceptScore W2085754534C2777056448 @default.
• W2085754534 hasConceptScore W2085754534C2777363265 @default.
• W2085754534 hasConceptScore W2085754534C55493867 @default.
• W2085754534 hasConceptScore W2085754534C71924100 @default.
• W2085754534 hasConceptScore W2085754534C84393581 @default.
• W2085754534 hasConceptScore W2085754534C86803240 @default.
• W2085754534 hasConceptScore W2085754534C98274493 @default.
• W2085754534 hasIssue "9" @default.
• W2085754534 hasLocation W20857545341 @default.
• W2085754534 hasLocation W20857545342 @default.
• W2085754534 hasOpenAccess W2085754534 @default.
• W2085754534 hasPrimaryLocation W20857545341 @default.
• W2085754534 hasRelatedWork W1980362630 @default.
• W2085754534 hasRelatedWork W2016605751 @default.
• W2085754534 hasRelatedWork W2026486289 @default.
• W2085754534 hasRelatedWork W2084665561 @default.
• W2085754534 hasRelatedWork W2132472749 @default.
• W2085754534 hasRelatedWork W2147616806 @default.
• W2085754534 hasRelatedWork W2358605929 @default.
• W2085754534 hasRelatedWork W2373403320 @default.

• next