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• W2085754834 abstract "Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction." @default.
• W2085754834 created "2016-06-24" @default.
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• W2085754834 creator A5052981865 @default.
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• W2085754834 date "2010-10-01" @default.
• W2085754834 modified "2023-09-30" @default.
• W2085754834 title "The role of RhoA/Rho kinase pathway in endothelial dysfunction" @default.
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• W2085754834 doi "https://doi.org/10.4103/0975-3583.74258" @default.
• W2085754834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3023892" @default.
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• W2085754834 hasPublicationYear "2010" @default.
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