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• W2085755758 abstract "The synthesis of several amphiphilic, nonpeptidic scaffolds that mimic the presentation of i, i + 3 or i + 4, and i + 7 residues of a peptide α-helix is described. The approach uses a pyridazine core, and the synthesis involves only a few steps and minimizes the number of C−C bond-forming reactions. The versatility of the synthesis makes it suitable for the preparation of small libraries of low molecular weight α-helix mimetics that could be targeted to certain protein/protein interactions." @default.
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• W2085755758 date "2007-08-21" @default.
• W2085755758 modified "2023-10-15" @default.
• W2085755758 title "Synthesis of Pyridazine-Based Scaffolds as α-Helix Mimetics" @default.
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• W2085755758 doi "https://doi.org/10.1021/ol701487g" @default.
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