FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085756064> ?p ?o ?g. }

• W2085756064 endingPage "522" @default.
• W2085756064 startingPage "507" @default.
• W2085756064 abstract "ABSTRACT: Cocaine is thought to be addictive because chronic use leads to molecular adaptations within the mesolimbic dopamine (DA) circuitry, which affects motivated behavior and emotion. Although the reinforcing effects of cocaine are mediated primarily by blockade of DA uptake, reciprocal signaling between DA and endogenous opioids has important implications for understanding cocaine dependence. We have used in vitro autoradiography and ligand binding to map D 3 DA and kappa opioid receptors in the human brains of cocaine‐overdose victims. The number of D 3 binding sites was increased one‐ to threefold over the nucleus accumbens and ventromedial sectors of the caudate and putamen from cocaine‐overdose victims, as compared to age‐matched and drug‐free control subjects. D 3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased sixfold in cocaine‐overdose victims over control values, suggesting that cocaine exposure also affects the expression of D 3 receptor mRNA. The number of kappa opioid receptors in the nucleus accumbens and other corticolimbic areas from cocaine fatalities was increased twofold as compared to control values. Cocaine‐overdose victims exhibiting preterminal excited delirium had a selective upregulation of kappa receptors measured also in the amygdala. Understanding the complex regulatory profiles of DA and opioid synaptic markers that occur with chronic misuse of cocaine may suggest multitarget strategies for treating cocaine dependence." @default.
• W2085756064 created "2016-06-24" @default.
• W2085756064 creator A5032248452 @default.
• W2085756064 creator A5084723460 @default.
• W2085756064 date "1999-06-01" @default.
• W2085756064 modified "2023-10-17" @default.
• W2085756064 title "D₃ Dopamine and Kappa Opioid Receptor Alterations in Human Brain of Cocaine‐overdose Victims" @default.
• W2085756064 cites W1922752440 @default.
• W2085756064 cites W1963562655 @default.
• W2085756064 cites W1966092598 @default.
• W2085756064 cites W1967823110 @default.
• W2085756064 cites W1970253831 @default.
• W2085756064 cites W1970822193 @default.
• W2085756064 cites W1972505350 @default.
• W2085756064 cites W1976808064 @default.
• W2085756064 cites W1985582613 @default.
• W2085756064 cites W2003165750 @default.
• W2085756064 cites W2007604257 @default.
• W2085756064 cites W2010806790 @default.
• W2085756064 cites W2013690942 @default.
• W2085756064 cites W2017213666 @default.
• W2085756064 cites W2017307344 @default.
• W2085756064 cites W2020245525 @default.
• W2085756064 cites W2032643119 @default.
• W2085756064 cites W2038505533 @default.
• W2085756064 cites W2040873559 @default.
• W2085756064 cites W2042221606 @default.
• W2085756064 cites W2046983320 @default.
• W2085756064 cites W2048937194 @default.
• W2085756064 cites W2052630265 @default.
• W2085756064 cites W2058213757 @default.
• W2085756064 cites W2060509660 @default.
• W2085756064 cites W2061161259 @default.
• W2085756064 cites W2065900388 @default.
• W2085756064 cites W2075831107 @default.
• W2085756064 cites W2077707065 @default.
• W2085756064 cites W2080482285 @default.
• W2085756064 cites W2089886527 @default.
• W2085756064 cites W2094554392 @default.
• W2085756064 cites W2095217951 @default.
• W2085756064 cites W2130174809 @default.
• W2085756064 cites W2133672910 @default.
• W2085756064 cites W2135768739 @default.
• W2085756064 cites W2155078368 @default.
• W2085756064 cites W2316853317 @default.
• W2085756064 cites W2467214725 @default.
• W2085756064 cites W99942916 @default.
• W2085756064 doi "https://doi.org/10.1111/j.1749-6632.1999.tb09286.x" @default.
• W2085756064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10415668" @default.
• W2085756064 hasPublicationYear "1999" @default.
• W2085756064 type Work @default.
• W2085756064 sameAs 2085756064 @default.
• W2085756064 citedByCount "102" @default.
• W2085756064 countsByYear W20857560642012 @default.
• W2085756064 countsByYear W20857560642013 @default.
• W2085756064 countsByYear W20857560642014 @default.
• W2085756064 countsByYear W20857560642015 @default.
• W2085756064 countsByYear W20857560642016 @default.
• W2085756064 countsByYear W20857560642017 @default.
• W2085756064 countsByYear W20857560642018 @default.
• W2085756064 countsByYear W20857560642019 @default.
• W2085756064 countsByYear W20857560642020 @default.
• W2085756064 countsByYear W20857560642021 @default.
• W2085756064 countsByYear W20857560642022 @default.
• W2085756064 countsByYear W20857560642023 @default.
• W2085756064 crossrefType "journal-article" @default.
• W2085756064 hasAuthorship W2085756064A5032248452 @default.
• W2085756064 hasAuthorship W2085756064A5084723460 @default.
• W2085756064 hasConcept C126322002 @default.
• W2085756064 hasConcept C137183658 @default.
• W2085756064 hasConcept C14397066 @default.
• W2085756064 hasConcept C151077648 @default.
• W2085756064 hasConcept C15744967 @default.
• W2085756064 hasConcept C169760540 @default.
• W2085756064 hasConcept C170493617 @default.
• W2085756064 hasConcept C184389661 @default.
• W2085756064 hasConcept C2776552330 @default.
• W2085756064 hasConcept C2777650357 @default.
• W2085756064 hasConcept C2779796075 @default.
• W2085756064 hasConcept C2780948618 @default.
• W2085756064 hasConcept C2780948874 @default.
• W2085756064 hasConcept C2781063702 @default.
• W2085756064 hasConcept C48856860 @default.
• W2085756064 hasConcept C513476851 @default.
• W2085756064 hasConcept C71924100 @default.
• W2085756064 hasConcept C88016717 @default.
• W2085756064 hasConcept C98274493 @default.
• W2085756064 hasConceptScore W2085756064C126322002 @default.
• W2085756064 hasConceptScore W2085756064C137183658 @default.
• W2085756064 hasConceptScore W2085756064C14397066 @default.
• W2085756064 hasConceptScore W2085756064C151077648 @default.
• W2085756064 hasConceptScore W2085756064C15744967 @default.
• W2085756064 hasConceptScore W2085756064C169760540 @default.
• W2085756064 hasConceptScore W2085756064C170493617 @default.
• W2085756064 hasConceptScore W2085756064C184389661 @default.
• W2085756064 hasConceptScore W2085756064C2776552330 @default.
• W2085756064 hasConceptScore W2085756064C2777650357 @default.
• W2085756064 hasConceptScore W2085756064C2779796075 @default.

• next