FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085756375> ?p ?o ?g. }

• W2085756375 endingPage "760" @default.
• W2085756375 startingPage "753" @default.
• W2085756375 abstract "Hyperosmotic stress causes cell death through activation of apoptotic pathways if the protective osmolyte response is impaired. In this study we attempt to elucidate the molecular mechanisms of hypertonicity-induced apoptosis and the effect of major organic osmolytes upon those.Hypertonicity-induced changes in Bcl2-family protein abundance and the presence of cytochrome c and apoptosis inducing factor (AIF) in the cytoplasm, were measured using western blot and immunofluorescence labeling. To determine dissipation of mitochondrial membrane potential (Delta Psi) though the permeability transition pore (PTP), the lipophilic cationic carbocyanine fluorescence probe JC-1 and TMRM fluorescence probes were used.Hypertonic culture conditions increase the abundance of proapoptotic Bax and the concentration of cytochrome c and apoptosis inducing factor (AIF) in the cytoplasm. These changes are associated with a dissipation of Delta Psi and increased permeability of the PTP. We further show that organic osmolytes stabilize the Delta Psi and decrease the concentration of cytochrome c and AIF in the cytoplasm.Our study shows that organic osmolytes prevent hypertonicity-induced apoptosis by preventing dissipation of Delta Psi through stabilization of the PTP. These findings further support the important role of organic osmolytes in preventing hypertonicity-mediated cell death in medullary kidney cells." @default.
• W2085756375 created "2016-06-24" @default.
• W2085756375 creator A5001330715 @default.
• W2085756375 creator A5066716873 @default.
• W2085756375 creator A5068707563 @default.
• W2085756375 creator A5087711022 @default.
• W2085756375 date "2010-01-01" @default.
• W2085756375 modified "2023-09-24" @default.
• W2085756375 title "Hypertonicity-induced Mitochondrial Membrane Permeability in Renal Medullary Interstitial Cells: Protective Role of Osmolytes" @default.
• W2085756375 cites W1515131982 @default.
• W2085756375 cites W1571115460 @default.
• W2085756375 cites W1976226379 @default.
• W2085756375 cites W1979995768 @default.
• W2085756375 cites W1986115510 @default.
• W2085756375 cites W1986568749 @default.
• W2085756375 cites W2019968039 @default.
• W2085756375 cites W2026735537 @default.
• W2085756375 cites W2036529420 @default.
• W2085756375 cites W2040162152 @default.
• W2085756375 cites W2041713757 @default.
• W2085756375 cites W2045556698 @default.
• W2085756375 cites W2063362926 @default.
• W2085756375 cites W2070764343 @default.
• W2085756375 cites W2096510468 @default.
• W2085756375 cites W2102076803 @default.
• W2085756375 cites W2103235619 @default.
• W2085756375 cites W2108131089 @default.
• W2085756375 cites W2109564403 @default.
• W2085756375 cites W2112225255 @default.
• W2085756375 cites W2112860230 @default.
• W2085756375 cites W2128635872 @default.
• W2085756375 cites W2130866079 @default.
• W2085756375 cites W2132411546 @default.
• W2085756375 cites W2143952085 @default.
• W2085756375 cites W2159650080 @default.
• W2085756375 cites W2169230321 @default.
• W2085756375 cites W2277667842 @default.
• W2085756375 cites W2338435702 @default.
• W2085756375 doi "https://doi.org/10.1159/000315095" @default.
• W2085756375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3030460" @default.
• W2085756375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20511721" @default.
• W2085756375 hasPublicationYear "2010" @default.
• W2085756375 type Work @default.
• W2085756375 sameAs 2085756375 @default.
• W2085756375 citedByCount "12" @default.
• W2085756375 countsByYear W20857563752012 @default.
• W2085756375 countsByYear W20857563752013 @default.
• W2085756375 countsByYear W20857563752015 @default.
• W2085756375 countsByYear W20857563752016 @default.
• W2085756375 countsByYear W20857563752019 @default.
• W2085756375 countsByYear W20857563752021 @default.
• W2085756375 crossrefType "journal-article" @default.
• W2085756375 hasAuthorship W2085756375A5001330715 @default.
• W2085756375 hasAuthorship W2085756375A5066716873 @default.
• W2085756375 hasAuthorship W2085756375A5068707563 @default.
• W2085756375 hasAuthorship W2085756375A5087711022 @default.
• W2085756375 hasBestOaLocation W20857563751 @default.
• W2085756375 hasConcept C12554922 @default.
• W2085756375 hasConcept C127160389 @default.
• W2085756375 hasConcept C13591479 @default.
• W2085756375 hasConcept C185592680 @default.
• W2085756375 hasConcept C190283241 @default.
• W2085756375 hasConcept C29311851 @default.
• W2085756375 hasConcept C2992270614 @default.
• W2085756375 hasConcept C31573885 @default.
• W2085756375 hasConcept C41625074 @default.
• W2085756375 hasConcept C55493867 @default.
• W2085756375 hasConcept C86803240 @default.
• W2085756375 hasConcept C95444343 @default.
• W2085756375 hasConceptScore W2085756375C12554922 @default.
• W2085756375 hasConceptScore W2085756375C127160389 @default.
• W2085756375 hasConceptScore W2085756375C13591479 @default.
• W2085756375 hasConceptScore W2085756375C185592680 @default.
• W2085756375 hasConceptScore W2085756375C190283241 @default.
• W2085756375 hasConceptScore W2085756375C29311851 @default.
• W2085756375 hasConceptScore W2085756375C2992270614 @default.
• W2085756375 hasConceptScore W2085756375C31573885 @default.
• W2085756375 hasConceptScore W2085756375C41625074 @default.
• W2085756375 hasConceptScore W2085756375C55493867 @default.
• W2085756375 hasConceptScore W2085756375C86803240 @default.
• W2085756375 hasConceptScore W2085756375C95444343 @default.
• W2085756375 hasIssue "6" @default.
• W2085756375 hasLocation W20857563751 @default.
• W2085756375 hasLocation W20857563752 @default.
• W2085756375 hasLocation W20857563753 @default.
• W2085756375 hasLocation W20857563754 @default.
• W2085756375 hasOpenAccess W2085756375 @default.
• W2085756375 hasPrimaryLocation W20857563751 @default.
• W2085756375 hasRelatedWork W198139324 @default.
• W2085756375 hasRelatedWork W19916217 @default.
• W2085756375 hasRelatedWork W2000605323 @default.
• W2085756375 hasRelatedWork W2009040707 @default.
• W2085756375 hasRelatedWork W2018093151 @default.
• W2085756375 hasRelatedWork W2073254770 @default.
• W2085756375 hasRelatedWork W2109846975 @default.
• W2085756375 hasRelatedWork W2117173714 @default.
• W2085756375 hasRelatedWork W2383263084 @default.
• W2085756375 hasRelatedWork W3046665064 @default.

• next