FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085756412> ?p ?o ?g. }

• W2085756412 endingPage "13" @default.
• W2085756412 startingPage "4" @default.
• W2085756412 abstract "This study examined whether the degree of brain dysmorphology observable in adulthood was related to onset age of schizophrenic symptoms. Brain magnetic resonance imaging (MRI) scans were acquired in 57 men with schizophrenia, whose age at MRI was 19–53 years, and whose symptom onset ranged from age 7 to 29 years; all were inpatients in a state hospital. Volumes of intracranial space, cortical gray matter (GM) and white matter (WM), and cerebrospinal fluid (CSF) in lateral and third ventricles and cortical sulci were derived from MRI scans and corrected by regression analysis for variations attributable to age and head size, quantified in a control sample of healthy community volunteers. The schizophrenic patients had larger volumes of cortical and ventricular CSF and smaller volumes of cortical GM but not WM than age-matched controls, whether or not volumes were adjusted for head size and age norms. Age of onset did not correlate with any of the five age-adjusted brain measures. Neither current age, length of illness, nor symptom severity correlated with age-normalized volumes of cortical GM, sulcal CSF, or ventricular CSF. These observations are consistent with the theory that brain structure deficits 1) first develop prior to symptom onset (perhaps during the prenatal and/or early childhood process of GM development); 2) probably establish a vulnerability to subsequent dysfunctionality; but 3) are nonprogressive. This study examined whether the degree of brain dysmorphology observable in adulthood was related to onset age of schizophrenic symptoms. Brain magnetic resonance imaging (MRI) scans were acquired in 57 men with schizophrenia, whose age at MRI was 19–53 years, and whose symptom onset ranged from age 7 to 29 years; all were inpatients in a state hospital. Volumes of intracranial space, cortical gray matter (GM) and white matter (WM), and cerebrospinal fluid (CSF) in lateral and third ventricles and cortical sulci were derived from MRI scans and corrected by regression analysis for variations attributable to age and head size, quantified in a control sample of healthy community volunteers. The schizophrenic patients had larger volumes of cortical and ventricular CSF and smaller volumes of cortical GM but not WM than age-matched controls, whether or not volumes were adjusted for head size and age norms. Age of onset did not correlate with any of the five age-adjusted brain measures. Neither current age, length of illness, nor symptom severity correlated with age-normalized volumes of cortical GM, sulcal CSF, or ventricular CSF. These observations are consistent with the theory that brain structure deficits 1) first develop prior to symptom onset (perhaps during the prenatal and/or early childhood process of GM development); 2) probably establish a vulnerability to subsequent dysfunctionality; but 3) are nonprogressive." @default.
• W2085756412 created "2016-06-24" @default.
• W2085756412 creator A5004843559 @default.
• W2085756412 creator A5006379970 @default.
• W2085756412 creator A5007925253 @default.
• W2085756412 creator A5015655458 @default.
• W2085756412 creator A5037359812 @default.
• W2085756412 creator A5043671103 @default.
• W2085756412 creator A5062030292 @default.
• W2085756412 creator A5072481624 @default.
• W2085756412 creator A5086406917 @default.
• W2085756412 creator A5088510294 @default.
• W2085756412 date "1996-07-01" @default.
• W2085756412 modified "2023-10-16" @default.
• W2085756412 title "Gray matter deficits in young onset schizophrenia are independent of age of onset" @default.
• W2085756412 cites W1540204836 @default.
• W2085756412 cites W1614690372 @default.
• W2085756412 cites W1805559889 @default.
• W2085756412 cites W1964388608 @default.
• W2085756412 cites W1964488079 @default.
• W2085756412 cites W1966460145 @default.
• W2085756412 cites W1974702488 @default.
• W2085756412 cites W1979985012 @default.
• W2085756412 cites W1980763739 @default.
• W2085756412 cites W1983766539 @default.
• W2085756412 cites W1984111997 @default.
• W2085756412 cites W1991891815 @default.
• W2085756412 cites W1995362640 @default.
• W2085756412 cites W1997739466 @default.
• W2085756412 cites W2018316534 @default.
• W2085756412 cites W2020987340 @default.
• W2085756412 cites W2022113071 @default.
• W2085756412 cites W2025011978 @default.
• W2085756412 cites W2030501289 @default.
• W2085756412 cites W2044054663 @default.
• W2085756412 cites W2049117931 @default.
• W2085756412 cites W2051054399 @default.
• W2085756412 cites W2051205891 @default.
• W2085756412 cites W2058160425 @default.
• W2085756412 cites W2058252306 @default.
• W2085756412 cites W2058739412 @default.
• W2085756412 cites W2061033236 @default.
• W2085756412 cites W2062187033 @default.
• W2085756412 cites W2062956681 @default.
• W2085756412 cites W2072486526 @default.
• W2085756412 cites W2073087131 @default.
• W2085756412 cites W2078026600 @default.
• W2085756412 cites W2078337693 @default.
• W2085756412 cites W2089692573 @default.
• W2085756412 cites W2097641036 @default.
• W2085756412 cites W2098607312 @default.
• W2085756412 cites W2099626510 @default.
• W2085756412 cites W2113359311 @default.
• W2085756412 cites W2115984740 @default.
• W2085756412 cites W2148412563 @default.
• W2085756412 cites W2166544051 @default.
• W2085756412 cites W4238870766 @default.
• W2085756412 doi "https://doi.org/10.1016/0006-3223(95)00356-8" @default.
• W2085756412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8780849" @default.
• W2085756412 hasPublicationYear "1996" @default.
• W2085756412 type Work @default.
• W2085756412 sameAs 2085756412 @default.
• W2085756412 citedByCount "66" @default.
• W2085756412 countsByYear W20857564122013 @default.
• W2085756412 countsByYear W20857564122015 @default.
• W2085756412 countsByYear W20857564122021 @default.
• W2085756412 countsByYear W20857564122022 @default.
• W2085756412 crossrefType "journal-article" @default.
• W2085756412 hasAuthorship W2085756412A5004843559 @default.
• W2085756412 hasAuthorship W2085756412A5006379970 @default.
• W2085756412 hasAuthorship W2085756412A5007925253 @default.
• W2085756412 hasAuthorship W2085756412A5015655458 @default.
• W2085756412 hasAuthorship W2085756412A5037359812 @default.
• W2085756412 hasAuthorship W2085756412A5043671103 @default.
• W2085756412 hasAuthorship W2085756412A5062030292 @default.
• W2085756412 hasAuthorship W2085756412A5072481624 @default.
• W2085756412 hasAuthorship W2085756412A5086406917 @default.
• W2085756412 hasAuthorship W2085756412A5088510294 @default.
• W2085756412 hasBestOaLocation W20857564121 @default.
• W2085756412 hasConcept C118552586 @default.
• W2085756412 hasConcept C126322002 @default.
• W2085756412 hasConcept C126838900 @default.
• W2085756412 hasConcept C143409427 @default.
• W2085756412 hasConcept C15744967 @default.
• W2085756412 hasConcept C164705383 @default.
• W2085756412 hasConcept C166275286 @default.
• W2085756412 hasConcept C169760540 @default.
• W2085756412 hasConcept C2776412080 @default.
• W2085756412 hasConcept C2777767895 @default.
• W2085756412 hasConcept C2779134260 @default.
• W2085756412 hasConcept C2779651940 @default.
• W2085756412 hasConcept C2781192897 @default.
• W2085756412 hasConcept C2989005 @default.
• W2085756412 hasConcept C58693492 @default.
• W2085756412 hasConcept C71924100 @default.
• W2085756412 hasConceptScore W2085756412C118552586 @default.
• W2085756412 hasConceptScore W2085756412C126322002 @default.
• W2085756412 hasConceptScore W2085756412C126838900 @default.

• next