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- W2085756906 abstract "Abstract Tilapia ( Oreochromis mossambicus ) of both sexes were fed a diet containing polychlorinated biphenyl (PCB) 126 (50 μ g kg −1 fish day −1 ) for 5 days to investigate whether a short-term exposure influences liver histology or lipid and glucose metabolism. Semiquantiative electron microscopical analysis confirmed gender-related differences in hepatocyte ultrastructure in sham-treated tilapia as described previously for other fish species. In hepatocytes from males, the amount of glycogen deposits was much larger than in females, as was the number of lipid droplets. Hepatocytes of females had larger amounts of perinuclear rough and smooth endoplasmic reticulum and larger lipid droplets. The treatment led to PCB accumulation in livers of exposed fish to levels previously reported for livers of fish caught from polluted areas. Concurrently, the amount of rough and smooth endoplasmic reticulum and the number of lysosomes increased in the livers of tilapia of both sexes. The cytoplasm became more diffuse and the glycogen space was reduced. In female tilapia lipid droplets increased in number but became smaller in size, while lipid droplets in hepatocytes of males were unaffected. Quantitative light microscopical morphometric analysis of liver sections revealed an increase in cell area after PCB treatment in females only. In males and females a decrease in nuclear area was observed. Because (a) the histological changes observed were moderate and not of an overt pathologic nature, and (b) no changes in basal plasma glucose and free fatty acid levels were observed, it is concluded that the stress-free administration of PCB led to a new equilibrium between mobilisation and tissue uptake of glucose and free fatty acids." @default.
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- W2085756906 date "1998-05-01" @default.
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- W2085756906 title "The influence of polychlorinated biphenyl 126 on tilapia (Oreochromis mossambicus) liver" @default.
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- W2085756906 doi "https://doi.org/10.1016/s1095-6433(98)10010-7" @default.
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